{{Rsnum
|rsid=3758391
|Gene=SIRT1
|Chromosome=10
|position=69643342
|Orientation=plus
|GMAF=0.4729
|Assembly=GRCh37
|GenomeBuild=37.1
|dbSNPBuild=131
|geno1=(C;C)
|geno2=(C;T)
|geno3=(T;T)
}}
{{ population diversity
| geno1=(C;C)
| geno2=(C;T)
| geno3=(T;T)
| CEU | 54.9 | 36.3 | 8.8
| HCB | 1.5 | 33.6 | 65.0
| JPT | 0.9 | 34.5 | 64.6
| YRI | 46.9 | 44.9 | 8.2
| ASW | 40.4 | 47.4 | 12.3
| CHB | 1.5 | 33.6 | 65.0
| CHD | 0.9 | 25.7 | 73.4
| GIH | 19.8 | 46.5 | 33.7
| LWK | 46.4 | 41.8 | 11.8
| MEX | 24.1 | 43.1 | 32.8
| MKK | 46.8 | 43.6 | 9.6
| TSI | 48.0 | 45.1 | 6.9
| HapMapRevision=28
}}[[rs3758391]], a SNP in the [[SIRT1]] gene, has been reported to potentially have some role in either longevity, or with higher statistical significance, better cognitive function in older individuals. [[SIRT1]] is thought to regulate neuronal metabolism and survival in response to stress, and the equivalent gene in other species influences maximal life span. The study reporting improved cognition for carriers of [[rs3758391(T)]] alleles was based on over 1,000 Finnish adults over the age of 85, and a weak trend towards lower cardiovascular disease was also reported for this allele. {{PMID|17895433}}

{{PMID Auto
|PMID=20503258
|Title=Candidate gene association study conditioning on individual ancestry in patients with type 2 diabetes and metabolic syndrome from Mexico City
}}
{{PMID Auto
|PMID=20633545
|Title=SIRT1 variants are associated with aging in a healthy Han Chinese population
}}

{{PMID Auto
|PMID=23450480
|Title=[Association between SIRT1 gene polymorphisms and longevity of populations from Yongfu region of Guangxi]
}}

{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | FTDNA2}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}