{{Rsnum
|rsid=3758549
|Gene=GBF1
|Chromosome=10
|position=104004195
|Orientation=minus
|GMAF=0.1405
|Assembly=GRCh37
|GenomeBuild=37.1
|dbSNPBuild=131
|geno1=(C;C)
|geno2=(C;T)
|geno3=(T;T)
}}
{{ population diversity
| geno1=(C;C)
| geno2=(C;T)
| geno3=(T;T)
| CEU | 61.9 | 34.5 | 3.5
| HCB | 72.3 | 27.0 | 0.7
| JPT | 80.5 | 16.8 | 2.7
| YRI | 97.3 | 2.7 | 0.0
| ASW | 77.2 | 22.8 | 0.0
| CHB | 72.3 | 27.0 | 0.7
| CHD | 74.3 | 22.9 | 2.8
| GIH | 90.1 | 9.9 | 0.0
| LWK | 90.9 | 9.1 | 0.0
| MEX | 69.0 | 31.0 | 0.0
| MKK | 85.3 | 14.7 | 0.0
| TSI | 65.7 | 28.4 | 5.9
| HapMapRevision=28
}}CC linked to [[parkinson's disease]]

{{PMID|17905480}} We provide evidence for a novel, strong and reproducible association of the PITX3 promoter SNP [[rs3758549]] : C>T (p=0.004) with PD. The C-allele appears to be a recessive risk allele with an estimated population frequency of 83%.

{{PMID Auto
|PMID=19345444
|Title=Association of transcription factor polymorphisms PITX3 and EN1 with Parkinson's disease.
}}

{{PMID Auto
|PMID=21138504
|Title=The transcription factor Pitx3 is a risk modifier for Parkinson's disease in a Chinese Han population
}}

{{PMID Auto
|PMID=21524731
|Title=PITX3 gene polymorphism is associated with Parkinson's disease in Chinese population
}}

{{PMID Auto
|PMID=21565251
|Title=Genetic variants of the PITX3 gene are not associated with late-onset sporadic Parkinson's disease in a Chinese population
}}

{{PMID Auto
|PMID=22411443
|Title=A novel synonymous SNP in PITX3 is associated with Parkinson's disease in Chinese population
}}

{{PMID Auto
|PMID=18420308
|Title=PITX3 polymorphism is associated with early onset Parkinson's disease.
}}

{{PMID Auto
|PMID=19754401
|Title=The role of transcription factor Pitx3 in dopamine neuron development and Parkinson's disease.
|OA=1
}}

{{PMID Auto
|PMID=22037506
|Title=PITX3 polymorphism is not associated with Parkinson's disease in a Chinese population.
}}

{{PMID Auto
|PMID=24394914
|Title=Association between PITX3 promoter polymorphism and risk of Parkinson's disease: The impact of ethnicity and onset age
}}

{{PMID Auto
|PMID=24525476
|Title=PITX3 and Risk for Parkinson's Disease: A Systematic Review and Meta-Analysis
}}
{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | FTDNA2}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}