{{Rsnum
|rsid=3758653
|Gene=DRD4
|Chromosome=11
|position=636399
|Orientation=plus
|GMAF=0.2185
|Assembly=GRCh37
|GenomeBuild=37.1
|dbSNPBuild=131
|geno1=(C;C)
|geno2=(C;T)
|geno3=(T;T)
}}
{{ population diversity
| geno1=(C;C)
| geno2=(C;T)
| geno3=(T;T)
| CEU | 3.5 | 29.2 | 67.3
| HCB | 6.6 | 38.7 | 54.7
| JPT | 6.2 | 27.4 | 66.4
| YRI | 6.1 | 30.6 | 63.3
| ASW | 3.5 | 28.1 | 68.4
| CHB | 6.6 | 38.7 | 54.7
| CHD | 4.6 | 45.0 | 50.5
| GIH | 15.8 | 42.6 | 41.6
| LWK | 4.5 | 36.4 | 59.1
| MEX | 3.4 | 46.6 | 50.0
| MKK | 8.3 | 32.1 | 59.6
| TSI | 2.9 | 33.3 | 63.7
| HapMapRevision=28
}}{{PharmGKB
|RSID=rs3758653
|Name_s=
|Gene_s=DRD4, SCT, CDHR5
|Feature=
|Evidence=PubMed ID:19238168
|Annotation=This variant along with 3 other SNPs near DRD4 (4 SNP haplotype: rs3758653; rs916457; rs762502; rs11246226) is associated with tardive dyskinesia in male schizophrenia patients.
|Drugs=
|Drug Classes=
|Diseases=Schizophrenia; tardive dyskinesia
|Curation Level=Curated
|PharmGKB Accession ID=PA164892186
}}

{{PMID Auto
|PMID=22569179
|Title=Rs1076560, a functional variant of the dopamine D2 receptor gene, confers risk of schizophrenia in Han Chinese
}}

{{PMID Auto
|PMID=17089069
|Title=Association and synergistic interaction between promoter variants of the DRD4 gene in Japanese schizophrenics.
|OA=1
}}

{{PMID Auto
|PMID=18937842
|Title=The influence of serotonin- and other genes on impulsive behavioral aggression and cognitive impulsivity in children with attention-deficit/hyperactivity disorder (ADHD): Findings from a family-based association test (FBAT) analysis.
|OA=1
}}

{{PMID Auto
|PMID=19584173
|Title=Kininogen gene (KNG) variation has a consistent effect on aldosterone response to antihypertensive drug therapy: the GERA study.
|OA=1
}}

{{PMID Auto
|PMID=19673036
|Title=Association of tagging single nucleotide polymorphisms on 8 candidate genes in dopaminergic pathway with schizophrenia in Croatian population.
|OA=1
}}

{{PMID Auto
|PMID=22366260
|Title=A family-based association study of dopamine receptor D4 and mental retardation in Qinba region of China.
}}

{{GET Evidence
|impact=pharmacogenetic
|qualified_impact=Insufficiently evaluated pharmacogenetic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs3758653
|overall_frequency_n=21
|overall_frequency_d=128
|overall_frequency=0.164062
|n_genomes=21
|n_genomes_annotated=0
|n_haplomes=22
|n_articles=1
|n_articles_annotated=0
|in_pharmgkb=Y
|autoscore=1
|webscore=N
}}

{{PMID Auto
|PMID=25233244
|Title=Association study of dopamine receptor genes polymorphism with cognitive functions in bipolar I disorder patients
}}
{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | FTDNA2}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}