{{Rsnum
|rsid=375947
|Gene=IL12RB1
|Chromosome=19
|position=18069641
|Orientation=plus
|GMAF=0.2893
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
|Gene_s=IL12RB1
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;G)
| geno3=(G;G)
| CEU | 42.0 | 45.5 | 12.5
| HCB | 48.2 | 38.7 | 13.1
| JPT | 33.9 | 55.4 | 10.7
| YRI | 59.2 | 33.3 | 7.5
| ASW | 59.6 | 31.6 | 8.8
| CHB | 48.2 | 38.7 | 13.1
| CHD | 37.0 | 50.9 | 12.0
| GIH | 53.5 | 43.6 | 3.0
| LWK | 64.5 | 27.3 | 8.2
| MEX | 70.7 | 29.3 | 0.0
| MKK | 50.3 | 41.3 | 8.4
| TSI | 36.6 | 52.5 | 10.9
| HapMapRevision=28
}}{{PMID Auto
|PMID=20060272
|Title=Association of single nucleotide polymorphisms in the IL-12 (IL-12A and B) and IL-12 receptor (IL-12Rbeta1 and beta2) genes and gene-gene interactions with atopic dermatitis in Koreans
}}

{{PMID Auto
|PMID=16600026
|Title=Asthma families show transmission disequilibrium of gene variants in the vitamin D metabolism and signalling pathway.
|OA=1
}}

{{PMID Auto
|PMID=17236132
|Title=A large-scale genetic association study confirms IL12B and leads to the identification of IL23R as psoriasis-risk genes.
|OA=1
}}

{{PMID Auto
|PMID=19235914
|Title=Genetic epistasis of IL23/IL17 pathway genes in Crohn's disease.
|OA=1
}}

{{PMID Auto
|PMID=19460324
|Title=A 475 years-old founder effect involving IL12RB1: a highly prevalent mutation conferring Mendelian Susceptibility to Mycobacterial Diseases in European descendants.
|OA=1
}}

{{PMID Auto
|PMID=20525402
|Title=Analysis of eight genes modulating interferon gamma and human genetic susceptibility to tuberculosis: a case-control association study.
|OA=1
}}

{{PMID Auto
|PMID=20811626
|Title=Genetic variants in inflammation-related genes are associated with radiation-induced toxicity following treatment for non-small cell lung cancer.
|OA=1
}}

{{GET Evidence
|gene=IL12RB1
|aa_change=Met365Thr
|aa_change_short=M365T
|impact=not reviewed
|qualified_impact=Insufficiently evaluated not reviewed
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs375947
|overall_frequency_n=2978
|overall_frequency_d=10290
|overall_frequency=0.289407
|n_genomes=29
|n_genomes_annotated=0
|n_haplomes=36
|n_articles=0
|n_articles_annotated=0
|gene_in_genetests=Y
|genetests_testable=Y
|nblosum100=2
|autoscore=2
|n_web_uneval=10
}}

{{PMID Auto
|PMID=23996684
|Title=Cytokine and cytokine receptor genes of the adaptive immune response are differentially associated with breast cancer risk in American women of African and European ancestry
}}
{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | FTDNA2}}
{{on chip | Illumina Human 1M}}