{{Rsnum
|rsid=3761218
|Gene=CDC25B
|Chromosome=20
|position=3795528
|Orientation=plus
|GMAF=0.337
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;T)
|geno3=(T;T)
|Gene_s=CDC25B
}}{{ population diversity
| geno1=(C;C)
| geno2=(C;T)
| geno3=(T;T)
| CEU | 19.5 | 51.3 | 29.2
| HCB | 11.7 | 45.3 | 43.1
| JPT | 5.3 | 45.1 | 49.6
| YRI | 4.1 | 34.0 | 61.9
| ASW | 7.0 | 38.6 | 54.4
| CHB | 11.7 | 45.3 | 43.1
| CHD | 6.4 | 40.4 | 53.2
| GIH | 27.7 | 48.5 | 23.8
| LWK | 4.5 | 42.7 | 52.7
| MEX | 15.5 | 41.4 | 43.1
| MKK | 9.0 | 39.7 | 51.3
| TSI | 14.7 | 58.8 | 26.5
| HapMapRevision=28
}}[[rs3761218]] has been reported in a large study to be associated with [[bipolar disorder]].

The risk allele (oriented to the dbSNP entry) is (C); the odds ratio associated with heterozygotes is 0.97 (CI 0.81-1.15), and for homozygotes, 1.31 (CI 1.09-1.57). {{PMID|17554300|OA=1
}}

{{GWAS Summary
|SNP=rs3761218
|PubMedID=17554300
|Condition=Bipolar disorder
|Gene=NR
|Risk Allele=C
|pValue=7.00E-006
|OR=1.03
|95CI=1.15-1.23
|OA=1
}}

{{PharmGKB
|RSID=rs3761218
|Name_s=
|Gene_s=CENPB, CDC25B
|Feature=
|Evidence=PubMed ID:17554300; Web Resource:http://www.genome.gov/gwastudies/
|Annotation=GWAS Results: Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls (Initial Sample Size: 1,868 cases, 2,938 controls; Replication Sample Size: NR; Risk Allele: rs3761218-C). This variant is associated with bipolar disorder.
|Drugs=
|Drug Classes=
|Diseases=Bipolar Disorder
|Curation Level=Non-Curated
|PharmGKB Accession ID=PA162356652
}}

{{PMID Auto GWAS
|PMID=21254220
|Trait=None
|Title=Propensity score-based nonparametric test revealing genetic variants underlying bipolar disorder.
|RiskAllele=
|Pval=0.000001
|OR=None
|ORtxt=None
|OA=1
}}

{{PMID|19308021|OA=1
}} Findings from bipolar disorder genome-wide association studies replicate in a Finnish bipolar family-cohort.

{{GET Evidence
|impact=pathogenic
|qualified_impact=Insufficiently evaluated pathogenic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs3761218
|overall_frequency_n=83
|overall_frequency_d=128
|overall_frequency=0.648438
|n_genomes=47
|n_genomes_annotated=0
|n_haplomes=75
|n_articles=0
|n_articles_annotated=0
|in_gwas=Y
|in_pharmgkb=Y
|autoscore=2
|webscore=N
}}

{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Affy GenomeWide 6}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}