{{Rsnum
|rsid=3761847
|Gene=TRAF1
|Chromosome=9
|position=120927961
|Orientation=plus
|GMAF=0.4816
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
|Gene_s=TRAF1
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;G)
| geno3=(G;G)
| CEU | 24.8 | 54.9 | 20.4
| HCB | 29.2 | 50.4 | 20.4
| JPT | 30.1 | 49.6 | 20.4
| YRI | 11.6 | 57.1 | 31.3
| ASW | 26.3 | 54.4 | 19.3
| CHB | 29.2 | 50.4 | 20.4
| CHD | 22.0 | 59.6 | 18.3
| GIH | 50.5 | 41.6 | 7.9
| LWK | 4.5 | 40.9 | 54.5
| MEX | 27.6 | 55.2 | 17.2
| MKK | 14.1 | 41.7 | 44.2
| TSI | 37.3 | 44.1 | 18.6
| HapMapRevision=28
}}[[rs3761847]], a SNP located between two genes associated with chronic inflammation ([[TRAF1]] and [[C5]]), is associated with increased risk of anti CCP-positive [[rheumatoid arthritis]].

The risk allele is (G); the odds ratio reported is 1.32 (95% confidence interval, 1.23 to 1.42; P=4x10-14) {{PMID|17804836|OA=1
}}.

{{PMID|19116907}} rs3761847(G;G) associated with an increased risk of death (hazard ratio 3.96 [95% confidence interval 1.24-12.6], P = 0.020) as compared with (A;A) homozygote status. The excess mortality was attributed to deaths due to malignancies and sepsis but not cardiovascular disease (CVD).

{{ neighbor
| rsid = 2416806
| distance = 53
}}

{{GWAS Summary
|SNP=rs3761847
|PubMedID=17804836
|Condition=Rheumatoid arthritis
|Gene=TRAF1-C5
|Risk Allele=G
|pValue=4.00E-014
|OR=1.32
|95CI=1.23-1.42
|OA=1
}}

{{PMID Auto
|PMID=19401279
|Title=Susceptibility variants for rheumatoid arthritis in the TRAF1-C5 and 6q23 loci: a meta-analysis
}}

{{PMID Auto
|PMID=19565500
|Title=Variants in TNFAIP3, STAT4, and C12orf30 loci associated with multiple autoimmune diseases are also associated with juvenile idiopathic arthritis
|OA=1
}}

{{omim
|desc=RHEUMATOID ARTHRITIS; RA
|id=180300
|rsnum=3761847
}}

{{omim
|desc=COMPLEMENT COMPONENT 5; C5
|id=120900
|rsnum=3761847
}}

{{omim
|desc=TNF RECEPTOR-ASSOCIATED FACTOR 1; TRAF1
|id=601711
|rsnum=3761847
}}
{{PMID Auto
|PMID=19714643
|Title=TRAF1 polymorphisms associated with rheumatoid arthritis susceptibility in Asians and in Caucasians
}}

{{PharmGKB
|RSID=rs3761847
|Name_s=
|Gene_s=TRAF1
|Feature=
|Evidence=PubMed ID:17804836; Web Resource:http://www.genome.gov/gwastudies/
|Annotation=GWAS Results: TRAF1-C5 as a risk locus for rheumatoid arthritis--a genomewide study (Initial Sample Size: 1,493 cases, 1,831 controls; Replication Sample Size: 1,053 cases, 1,858 controls; Risk Allele: rs3761847-G).
|Drugs=
|Drug Classes=
|Diseases=Arthritis, Rheumatoid
|Curation Level=Non-Curated
|PharmGKB Accession ID=PA162356690
}}

{{PMID Auto
|PMID=19336421
|Title=Association study of TRAF1-C5 polymorphisms with susceptibility to rheumatoid arthritis and systemic lupus erythematosus in Japanese
}}

{{PMID Auto GWAS
|PMID=20453842
|Trait=Rheumatoid arthritis
|Title=Genome-wide association study meta-analysis identifies seven new rheumatoid arthritis risk lock
|RiskAllele=G
|Pval=2E-7
|OR=1.13
|ORtxt=[1.08-1.18]
}}

{{PMID Auto
|PMID=18224312
|Title=Pharmacogenetics: data, concepts and tools to improve drug discovery and drug treatment.
|OA=1
}}

{{PMID Auto
|PMID=18434327
|Title=Re-evaluation of putative rheumatoid arthritis susceptibility genes in the post-genome wide association study era and hypothesis of a key pathway underlying susceptibility.
|OA=1
}}

{{PMID Auto
|PMID=18648537
|Title=A large-scale rheumatoid arthritis genetic study identifies association at chromosome 9q33.2.
|OA=1
}}

{{PMID Auto
|PMID=18794853
|Title=Common variants at CD40 and other loci confer risk of rheumatoid arthritis.
|OA=1
}}

{{PMID Auto
|PMID=18987647
|Title=Rheumatoid arthritis: a view of the current genetic landscape.
|OA=1
}}

{{PMID Auto
|PMID=19180477
|Title=Genetic risk factors for rheumatoid arthritis differ in Caucasian and Korean populations.
|OA=1
}}

{{PMID Auto
|PMID=19445664
|Title=Association of common polymorphisms in known susceptibility genes with rheumatoid arthritis in a Slovak population using osteoarthritis patients as controls.
|OA=1
}}

{{PMID Auto
|PMID=19674979
|Title=Overlap of disease susceptibility loci for rheumatoid arthritis and juvenile idiopathic arthritis.
|OA=1
}}

{{PMID Auto
|PMID=19849816
|Title=Genetics of rheumatic disease.
|OA=1
}}

{{PMID Auto
|PMID=20017974
|Title=Simultaneous analysis of all single-nucleotide polymorphisms in genome-wide association study of rheumatoid arthritis.
|OA=1
}}

{{PMID Auto
|PMID=20017985
|Title=Adjusting for HLA-DRbeta1 in a genome-wide association analysis of rheumatoid arthritis and related biomarkers.
|OA=1
}}

{{PMID Auto
|PMID=20017996
|Title=Effect of population stratification on the identification of significant single-nucleotide polymorphisms in genome-wide association studies.
|OA=1
}}

{{PMID Auto
|PMID=20018005
|Title=Analysis of genome-wide association data by large-scale Bayesian logistic regression.
|OA=1
}}

{{PMID Auto
|PMID=20018006
|Title=Case-control genome-wide association study of rheumatoid arthritis from Genetic Analysis Workshop 16 using penalized orthogonal-components regression-linear discriminant analysis.
|OA=1
}}

{{PMID Auto
|PMID=20018022
|Title=Replication of recently identified associated single-nucleotide polymorphisms from six autoimmune diseases in Genetic Analysis Workshop 16 rheumatoid arthritis data.
|OA=1
}}

{{PMID Auto
|PMID=20018027
|Title=Conditional analysis of the major histocompatibility complex in rheumatoid arthritis.
|OA=1
}}

{{PMID Auto
|PMID=20018028
|Title=Armitage's trend test for genome-wide association analysis: one-sided or two-sided?
|OA=1
}}

{{PMID Auto
|PMID=20018035
|Title=A combinatorial approach for detecting gene-gene interaction using multiple traits of Genetic Analysis Workshop 16 rheumatoid arthritis data.
|OA=1
}}

{{PMID Auto
|PMID=20018053
|Title=A genome-wide association scan for rheumatoid arthritis data by Hotelling's T2 tests.
|OA=1
}}

{{PMID Auto
|PMID=20018062
|Title=Identification of genes and haplotypes that predict rheumatoid arthritis using random forests.
|OA=1
}}

{{PMID Auto
|PMID=20018071
|Title=Allelic based gene-gene interactions in rheumatoid arthritis.
|OA=1
}}

{{PMID Auto
|PMID=20018074
|Title=Identifying rheumatoid arthritis susceptibility genes using high-dimensional methods.
|OA=1
}}

{{PMID Auto
|PMID=20018075
|Title=Genome-wide association study of rheumatoid arthritis by a score test based on wavelet transformation.
|OA=1
}}

{{PMID Auto
|PMID=20018090
|Title=Comparative analysis of different approaches for dealing with candidate regions in the context of a genome-wide association study.
|OA=1
}}

{{PMID Auto
|PMID=20205706
|Title=TRAF1/C5 polymorphism is not associated with increased mortality in rheumatoid arthritis: two large longitudinal studies.
|OA=1
}}

{{PMID Auto
|PMID=20479942
|Title=Genetic risk factors in lupus nephritis and IgA nephropathy--no support of an overlap.
|OA=1
}}

{{PMID Auto
|PMID=20691091
|Title=Survival dimensionality reduction (SDR): development and clinical application of an innovative approach to detect epistasis in presence of right-censored data.
|OA=1
}}

{{GET Evidence
|impact=pathogenic
|qualified_impact=Insufficiently evaluated pathogenic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs3761847
|overall_frequency_n=68
|overall_frequency_d=128
|overall_frequency=0.53125
|n_genomes=44
|n_genomes_annotated=0
|n_haplomes=57
|n_articles=0
|n_articles_annotated=0
|in_gwas=Y
|in_pharmgkb=Y
|autoscore=2
|webscore=N
}}

{{PMID Auto
|PMID=22820624
|Title=Associations between TNFSF4 and TRAF1-C5 gene polymorphisms and systemic lupus erythematosus: a meta-analysis.
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}