{{Rsnum
|rsid=3764028
|Chromosome=12
|position=13982130
|Orientation=minus
|GMAF=0.2107
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;C)
|geno3=(C;C)
}}[[rs3764028]] ( -421C/A ) is a SNP in close proximity to [[GRIN2B]] (Glutamate [NMDA] receptor subunit epsilon-2).

{{PMID|18983893}} significant differences in genotype between the North Chinese sporadic Alzheimer's patients (of which there were 362) and controls (of which there were 334). 34.69-39.79% decreased transcriptional activity (per luciferase reporter assay in SH-SY5Y and HeLa cell lines) noted for the C allele versus the A allele