{{Rsnum
|rsid=3764147
|Gene=C13orf31
|Chromosome=13
|position=43883789
|Orientation=plus
|ReferenceAllele=A
|MissenseAllele=G
|GMAF=0.3026
|Gene_s=LACC1
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;G)
| geno3=(G;G)
| CEU | 59.3 | 32.7 | 8.0
| HCB | 46.0 | 41.6 | 12.4
| JPT | 44.2 | 46.0 | 9.7
| YRI | 44.2 | 46.3 | 9.5
| ASW | 38.6 | 57.9 | 3.5
| CHB | 46.0 | 41.6 | 12.4
| CHD | 49.5 | 35.8 | 14.7
| GIH | 39.6 | 47.5 | 12.9
| LWK | 50.0 | 42.7 | 7.3
| MEX | 29.3 | 51.7 | 19.0
| MKK | 60.9 | 33.3 | 5.8
| TSI | 55.9 | 38.2 | 5.9
| HapMapRevision=28
}}{{GWAS Summary
|SNP=rs3764147
|PubMedID=18587394
|Condition=Crohn's disease
|Gene=Unknown
|Risk Allele=G
|pValue=2.00E-013
|OR=1.25
|95CI=
|OA=1
}}

{{PharmGKB
|RSID=rs3764147
|Name_s=
|Gene_s=C13orf31
|Feature=
|Evidence=PubMed ID:18587394; Web Resource:http://www.genome.gov/gwastudies/
|Annotation=GWAS Results: Genome-wide assocation defines more than 30 distinct susceptibility loci for Crohn's disease (Initial Sample Size: 3,230 cases 4,829 controls; Replication Sample Size: 2,325 cases 1,809 controls 1,339 affected trios; Risk Allele: rs3764147-G).
|Drugs=
|Drug Classes=
|Diseases=Crohn Disease
|Curation Level=Non-Curated
|PharmGKB Accession ID=PA162356804
}}

Variant in the [[C13orf31]] region associated with increased susceptibility to [[leprosy]], according to the 23andMe blog [http://blog.23andme.com/2009/12/16/snpwatch-genetic-association-study-of-leprosy-yields-new-insights-into-an-ancient-disease/ 23andMe blog]. The risk allele is G, and the odds ratio is 1.68.

Other genes associated with both [[Crohn's disease]] and [[leprosy]] include [[NOD2]] and [[TNFSF15]], according to [http://blog.23andme.com/2009/12/16/snpwatch-genetic-association-study-of-leprosy-yields-new-insights-into-an-ancient-disease/ 23andMe's blog].
{{PMID Auto GWAS
|PMID=20018961
|Trait=Leprosy
|Title=Genomewide Association Study of Leprosy
|RiskAllele=G
|Pval=4E-54
|OR=1.68
|ORtxt=[1.57-1.80]
}}

{{omim
|id=613407
|rsnum=3764147
}}

{{PMID Auto
|PMID=19068216
|Title=Investigation of Crohn's disease risk loci in ulcerative colitis further defines their molecular relationship.
|OA=1
}}

{{PMID Auto
|PMID=21304977
|Title=An investigation of genome-wide studies reported susceptibility loci for ulcerative colitis shows limited replication in north Indians.
|OA=1
}}

{{GET Evidence
|gene=C13ORF31
|aa_change=Ile254Val
|aa_change_short=I254V
|impact=pharmacogenetic
|qualified_impact=Insufficiently evaluated pharmacogenetic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs3764147
|overall_frequency_n=2731
|overall_frequency_d=10758
|overall_frequency=0.253858
|n_genomes=29
|n_genomes_annotated=0
|n_haplomes=36
|n_articles=0
|n_articles_annotated=0
|qualityscore_in_silico=3
|qualitycomment_in_silico=Y
|in_gwas=Y
|in_pharmgkb=Y
|nblosum100=-4
|autoscore=2
|webscore=N
}}

[[Leprosy Susceptibility]]

{{PMID Auto GWAS
  |PMID=23128233
  |Trait=Crohn's disease
  |Title=Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
  |RiskAllele=G
  |Pval=2E-21
  |OR=1.16
  |ORtxt=[1.112-1.199]
  |OA=1
}}

{{PMID Auto GWAS
  |PMID=21102463
  |Trait=Crohn's disease
  |Title=Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci.
  |RiskAllele=G
  |Pval=1E-10
  |OR=1.17
  |ORtxt=[1.12-1.23]
  |OA=1
}}

{{PMID Auto
|PMID=23974994
|Title=Replication Study of Ulcerative Colitis Risk Loci in a Lithuanian-Latvian Case-Control Sample
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Affy GenomeWide 6}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}