{{Rsnum
|rsid=3764261
|Chromosome=16
|position=56959412
|Orientation=minus
|GMAF=0.2695
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(G;G)
|geno2=(G;T)
|geno3=(T;T)
}}{{ population diversity
| geno1=(G;G)
| geno2=(G;T)
| geno3=(T;T)
| CEU | 43.4 | 44.2 | 12.4
| HCB | 68.4 | 29.4 | 2.2
| JPT | 63.7 | 30.1 | 6.2
| YRI | 48.3 | 44.1 | 7.6
| ASW | 47.4 | 38.6 | 14.0
| CHB | 68.4 | 29.4 | 2.2
| CHD | 71.3 | 27.8 | 0.9
| GIH | 36.6 | 49.5 | 13.9
| LWK | 36.7 | 46.8 | 16.5
| MEX | 48.3 | 39.7 | 12.1
| MKK | 41.7 | 47.4 | 10.9
| TSI | 50.0 | 40.2 | 9.8
| HapMapRevision=28
}}

T allele is associated with 3.47mg/dl increase in [[HDL cholesterol]] (good cholesterol). {{PMID|18193043}}

{{PMID Auto GWAS
|PMID=19060910
|Trait=HDL cholesterol
|Title=Genome-wide association analysis of metabolic traits in a birth cohort from a founder population
|RiskAllele=A
|Pval=7E-29
|OR=0.09
|ORtxt=[0.08-0.11] mmol/l increase
|OA=1
}}
{{PMID Auto GWAS
|PMID=18454146
|Trait=Waist circumference and related phenotypes
|Title=Common genetic variation near MC4R is associated with waist circumference and insulin resistance
|RiskAllele=
|Pval=1E-27
|OR=NR
|ORtxt=NR
}}
{{PMID Auto GWAS
|PMID=18193043
|Trait=HDL cholesterol
|Title=Newly identified loci that influence lipid concentrations and risk of coronary artery disease
|RiskAllele=A
|Pval=1.9999999999999999E-57
|OR=3.47
|ORtxt=[NR] mg/dl higher
}}

{{PMID Auto GWAS
|PMID=19359809
|Trait=LDL cholesterol
|Title=Identification of Genetic Markers Associated With High-Density Lipoprotein-Cholesterol by Genome-Wide Screening in a Japanese Population
|RiskAllele=A
|Pval=3E-12
|OR=6.20
|ORtxt=mg/dl increase
}}

{{PharmGKB
|RSID=rs3764261
|Name_s=
|Gene_s=CETP
|Feature=
|Evidence=PubMed ID:19802338
|Annotation=Phenotype: In a GWAS, this SNP was significantly associated with plasma concentrations of HDL-C and apolipoprotein A1. Study size: 6382. Study population/ethnicity: Caucasian women. Significance metric(s): HDL-C: p = 1.0 x 10 (-41);ApoA1: p = 1.1 x 10(-34). Type of association: CO; GN
|Drugs=
|Drug Classes=
|Diseases=Cardiovascular Diseases
|Curation Level=Curated
|PharmGKB Accession ID=PA165111815
}}

{{PMID Auto GWAS
|PMID=20385819
|Trait=Age-related macular degeneration
|Title=Genetic variants near TIMP3 and high-density lipoprotein-associated loci influence susceptibility to age-related macular degeneration
|RiskAllele=A
|Pval=7E-7
|OR=1.19
|ORtxt=[1.12-1.27]
|OA=1
}}
{{PMID Auto GWAS
|PMID=20686565
|Trait=None
|Title=Biological, clinical and population relevance of 95 loci for blood lipids
|RiskAllele=A
|Pval=0
|OR=3.39
|ORtxt=[NR] unit increase
|OA=1
}}
{{PMID Auto GWAS
|PMID=20694148
|Trait=None
|Title=A genome-wide association study of the metabolic syndrome in Indian Asian men
|RiskAllele=A
|Pval=1E-48
|OR=0.07
|ORtxt=[0.06-0.08] mmol/l increase
|OA=1
}}

{{PharmGKB
|RSID=rs3764261
|Name_s=
|Gene_s=CETP
|Feature=
|Evidence=PubMed ID:19060910; Web Resource:http://www.genome.gov/gwastudies/
|Annotation=GWAS results: Genome-wide association analysis of metabolic traits in a birth cohort from a founder population. (Initial Sample Size: 4,763 individuals; Replication Sample Size: NR); (Region: 16q13; Reported Gene(s): CETP; Risk Allele: rs3764261-A); (p-value= 7E-29).This variant is associated with HDL cholesterol.
|Drugs=
|Drug Classes=
|Diseases=
|Curation Level=Non-Curated
|PharmGKB Accession ID=PA164740274
}}

{{omim
|id=118470
|rsnum=3764261
}}

{{PMID Auto GWAS
|PMID=21386085
|Trait=None
|Title=A Bivariate Genome-Wide Approach to Metabolic Syndrome: STAMPEED Consortium
|RiskAllele=G
|Pval=3E-13
|OR=0.2900
|ORtxt=[0.21-0.37] unit increase
|OA=1
}}

{{PMID Auto
|PMID=21149302
|Title=Effects of genetic variants on lipid parameters and dyslipidemia in a Chinese population
|OA=1
}}

{{PMID Auto GWAS
|PMID=21665990
|Trait=None
|Title=Common variants near FRK/COL10A1 and VEGFA are associated with advanced age-related macular degeneration.
|RiskAllele=A
|Pval=7E-9
|OR=1.1500
|ORtxt=[NR]
|OA=1
}}

{{PMID Auto
|PMID=21831959
|Title=Race/Ethnic Variation in the Association of Lipid-Related Genetic Variants with Blood Lipids in the Adult U.S. Population
}}

{{PMID Auto
|PMID=22143414
|Title=Genetic variation in cholesterol ester transfer protein, serum CETP activity, and coronary artery disease risk in Asian Indian diabetic cohort
|OA=1
}}

{{PMID Auto
|PMID=22235250
|Title=Quantile-specific penetrance of genes affecting lipoproteins, adiposity and height
|OA=1
}}

{{PMID Auto GWAS
|PMID=22286219
|Trait=None
|Title=Genome-wide association study identifies multiple loci influencing human serum metabolite levels.
|RiskAllele=
|Pval=1E-36
|OR=0.2200
|ORtxt=None
|OA=1
}}

{{PMID Auto
|PMID=16700901
|Title=Physiogenomic analysis of weight loss induced by dietary carbohydrate restriction.
|OA=1
}}

{{PMID Auto
|PMID=17357073
|Title=Genetic analysis of 103 candidate genes for coronary artery disease and associated phenotypes in a founder population reveals a new association between endothelin-1 and high-density lipoprotein cholesterol.
|OA=1
}}

{{PMID Auto
|PMID=18194558
|Title=A hierarchical and modular approach to the discovery of robust associations in genome-wide association studies from pooled DNA samples.
|OA=1
}}

{{PMID Auto
|PMID=18254975
|Title=Physiogenomic comparison of human fat loss in response to diets restrictive of carbohydrate or fat.
|OA=1
}}

{{PMID Auto
|PMID=18852197
|Title=Metabolic and cardiovascular traits: an abundance of recently identified common genetic variants.
|OA=1
}}

{{PMID Auto
|PMID=19041386
|Title=Genetic-epidemiological evidence on genes associated with HDL cholesterol levels: a systematic in-depth review.
|OA=1
}}

{{PMID Auto
|PMID=19148283
|Title=Genetic differences between the determinants of lipid profile phenotypes in African and European Americans: the Jackson Heart Study.
|OA=1
}}

{{PMID Auto
|PMID=19299407
|Title=Replication of genetic associations with plasma lipoprotein traits in a multiethnic sample.
|OA=1
}}

{{PMID Auto
|PMID=19679263
|Title=Using new tools to define the genetic underpinnings of risky traits associated with coronary artery disease: the SardiNIA study.
|OA=1
}}

{{PMID Auto
|PMID=19682379
|Title=TagSNP transferability and relative loss of variability prediction from HapMap to an admixed population.
|OA=1
}}

{{PMID Auto
|PMID=19913121
|Title=Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.
|OA=1
}}

{{PMID Auto
|PMID=20018034
|Title=Multivariate association analysis of the components of metabolic syndrome from the Framingham Heart Study.
|OA=1
}}

{{PMID Auto
|PMID=20018039
|Title=Associating multiple longitudinal traits with high-dimensional single-nucleotide polymorphism data: application to the Framingham Heart Study.
|OA=1
}}

{{PMID Auto
|PMID=20018043
|Title=Defining genetic determinants of the Metabolic Syndrome in the Framingham Heart Study using association and structural equation modeling methods.
|OA=1
}}

{{PMID Auto
|PMID=20018089
|Title=Toward the identification of causal genes in complex diseases: a gene-centric joint test of significance combining genomic and transcriptomic data.
|OA=1
}}

{{PMID Auto
|PMID=20160193
|Title=Investigation of variants identified in caucasian genome-wide association studies for plasma high-density lipoprotein cholesterol and triglycerides levels in Mexican dyslipidemic study samples.
|OA=1
}}

{{PMID Auto
|PMID=20205905
|Title=Association of repeatedly measured intermediate risk factors for complex diseases with high dimensional SNP data.
|OA=1
}}

{{PMID Auto
|PMID=20369022
|Title=Candidate causal regulatory effects by integration of expression QTLs with complex trait genetic associations.
|OA=1
}}

{{PMID Auto
|PMID=20385826
|Title=Genome-wide association study of advanced age-related macular degeneration identifies a role of the hepatic lipase gene (LIPC).
|OA=1
}}

{{PMID Auto
|PMID=21283740
|Title=Large-scale candidate gene analysis of HDL particle features.
|OA=1
}}

{{PMID Auto
|PMID=21347282
|Title=Genome-wide association study of coronary heart disease and its risk factors in 8,090 African Americans: the NHLBI CARe Project.
|OA=1
}}

{{PMID Auto
|PMID=21430028
|Title=Association of GWAS-based candidate genes with HDL-cholesterol levels before and after bariatric surgery in the Swedish obese subjects study.
}}

{{GET Evidence
|impact=pathogenic
|qualified_impact=Insufficiently evaluated pathogenic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs3764261
|overall_frequency_n=43
|overall_frequency_d=128
|overall_frequency=0.335938
|n_genomes=32
|n_genomes_annotated=0
|n_haplomes=39
|n_articles=1
|n_articles_annotated=0
|in_gwas=Y
|in_pharmgkb=Y
|autoscore=2
|webscore=N
}}

{{PMID Auto
|PMID=23262498
|Title=Impact of geneticfactorsondyslipidemia in HIV-infected patients starting antiretroviral therapy
}}

{{PMID Auto GWAS
  |PMID=23118302
  |Trait=Lipoprotein-associated phospholipase A2 activity and mass
  |Title=Genome-wide association study evaluating lipoprotein-associated phospholipase A2 mass and activity at baseline and after rosuvastatin therapy.
  |RiskAllele=T
  |Pval=7E-21
  |OR=.02
  |ORtxt=[0.014-0.030] ng/ml increase
  }}

{{PMID Auto
|PMID=23050023
|Title=Association of genetic variants influencing lipid levels with coronary artery disease in Japanese individuals
|OA=1
}}

{{PMID Auto
|PMID=23861364
|Title=Do Genetic Modifiers of HDL-C and Triglyceride Levels also Modify Their Response to a Lifestyle Intervention in the Setting of Obesity and Type-2 Diabetes Mellitus? The Look AHEAD Study
}}

{{PMID Auto
|PMID=24080640
|Title=Cholesteryl ester transfer protein (CETP) polymorphisms, statin use, and their impact on cholesterol levels and cardiovascular events
}}

{{PMID Auto
|PMID=24223199
|Title=Association of HDL-Related Loci with Age-Related Macular Degeneration and Plasma Lutein and Zeaxanthin: the Alienor Study
|OA=1
}}

{{PMID Auto
|PMID=24393350
|Title=Genes in the High-Density Lipoprotein Metabolic Pathway in Age-Related Macular Degeneration and Polypoidal Choroidal Vasculopathy
}}

{{PMID Auto
|PMID=22715478
|Title=Genotypes associated with lipid metabolism contribute to differences in serum lipid profile of GH-deficient adults before and after GH replacement therapy.
}}

{{PMID Auto
|PMID=23675527
|Title=The association of common SNPs and haplotypes in CETP gene with HDL cholesterol levels in Latvian population.
|OA=1
}}

{{PMID Auto GWAS
  |PMID=24386095
  |Trait=Lipid traits
  |Title=A genome wide association study identifies common variants associated with lipid levels in the Chinese population.
  |RiskAllele=T
  |Pval=2E-25
  |OR=.06
  |ORtxt=[0.046-0.078] mmol/L increase
  }}
{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}