{{Rsnum
|rsid=3764880
|Gene=TLR8
|Chromosome=X
|position=12906707
|Orientation=plus
|ReferenceAllele=A
|MissenseAllele=G
|GMAF=0.4389
|Gene_s=TLR8,TLR8-AS1
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;G)
| geno3=(G;G)
| CEU | 69.2 | 13.8 | 16.9
| HCB | 8.9 | 26.7 | 64.4
| JPT | 15.9 | 22.7 | 61.4
| YRI | 58.7 | 22.2 | 19.0
| ASW | 0.0 | 0.0 | 0.0
| CHB | 8.9 | 26.7 | 64.4
| CHD | 0.0 | 0.0 | 0.0
| GIH | 0.0 | 0.0 | 0.0
| LWK | 0.0 | 0.0 | 0.0
| MEX | 0.0 | 0.0 | 0.0
| MKK | 0.0 | 0.0 | 0.0
| TSI | 0.0 | 0.0 | 0.0
| HapMapRevision=28
}}
[[rs3764880]] is a SNP in the [[TLR8]] gene, located on the X chromosome. [[rs3764880]] is also known as Met1Val.

A study of both Indonesian and Russian [[tuberculosis]] patients (and controls) concluded that the minor (A) allele of [[rs3764880]] was associated with increased risk for [[tuberculosis]]. In the Indonesian population of 375 patients, the odds ratio was 1.8 (CI: 1.2–2.7); in the Russian population of 1,837 patients, the odds ratio was 1.2 (CI: 1.02–1.48); the combined evidence for association was p = 1.2×10e?3 – 6×10e?4. Note that the association was found primarily in males (although also to a lesser extent in homozygous females), presumably due to the presence of only one X chromosome in males. {{PMID|18927625|OA=1
}}

{{PMID Auto
|PMID=20652908
|Title=Genetic modulation of TLR8 response following bacterial phagocytosis
}}

{{PMID|18605904}} A functional toll-like receptor 8 variant is associated with HIV disease restriction.

{{PMID|18985439}} Toll-like receptor 8 polymorphism and coronary artery disease.

{{PMID|19450131|OA=1
}} Application of pharmacogenomics to vaccines.

{{PMID|19505919|OA=1
}} Toll-like receptor signaling pathway variants and prostate cancer mortality.

{{PMID|20041166|OA=1
}} Common genetic variation and the control of HIV-1 in humans.

{{PMID|21872627}} Association of polymorphisms in TLR genes and in genes of the Toll-like receptor signaling pathway with cancer risk.

{{PMID|22065095}} TLR7/8/9 polymorphisms and their associations in systemic lupus erythematosus patients from southern Brazil.

{{GET Evidence
|gene=TLR8
|aa_change=Met1Val
|aa_change_short=M1V
|impact=not reviewed
|qualified_impact=Insufficiently evaluated not reviewed
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs3764880
|overall_frequency_n=2226
|overall_frequency_d=8761
|overall_frequency=0.254081
|n_genomes=29
|n_genomes_annotated=0
|n_haplomes=49
|n_articles=0
|n_articles_annotated=0
|pph2_score=0.966
|nblosum100=0
|autoscore=1
|webscore=N
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | FTDNA2}}
{{on chip | FTDNA}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}