{{Rsnum
|rsid=3765524
|Gene=PLCE1
|Chromosome=10
|position=96058298
|Orientation=plus
|GMAF=0.281
|Assembly=GRCh37
|GenomeBuild=37.1
|dbSNPBuild=131
|geno1=(C;C)
|geno2=(C;T)
|geno3=(T;T)
}}
{{ population diversity
| geno1=(C;C)
| geno2=(C;T)
| geno3=(T;T)
| CEU | 47.8 | 46.9 | 5.3
| HCB | 59.9 | 35.8 | 4.4
| JPT | 62.8 | 32.7 | 4.4
| YRI | 33.3 | 48.3 | 18.4
| ASW | 31.6 | 54.4 | 14.0
| CHB | 59.9 | 35.8 | 4.4
| CHD | 61.1 | 33.3 | 5.6
| GIH | 57.4 | 36.6 | 5.9
| LWK | 31.8 | 52.7 | 15.5
| MEX | 69.0 | 29.3 | 1.7
| MKK | 12.8 | 56.4 | 30.8
| TSI | 42.2 | 43.1 | 14.7
| HapMapRevision=28
}}{{PMID Auto GWAS
|PMID=20729852
|Trait=None
|Title=A shared susceptibility locus in PLCE1 at 10q23 for gastric adenocarcinoma and esophageal squamous cell carcinoma
|RiskAllele=T
|Pval=2E-9
|OR=1.35
|ORtxt=[1.22-1.49]
|OA=1
}}

{{omim
|id=133239
|rsnum=3765524
}}

{{PMID Auto GWAS
|PMID=22001756
|Trait=None
|Title=Genome-wide association study identifies susceptibility loci for dengue shock syndrome at MICB and PLCE1.
|RiskAllele=
|Pval=3E-10
|OR=1.2500
|ORtxt=None
|OA=1
}}

{{GET Evidence
|gene=PLCE1
|aa_change=Thr1777Ile
|aa_change_short=T1777I
|impact=not reviewed
|qualified_impact=Insufficiently evaluated not reviewed
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs3765524
|overall_frequency_n=3246
|overall_frequency_d=10098
|overall_frequency=0.32145
|n_genomes=40
|n_genomes_annotated=0
|n_haplomes=46
|n_articles=0
|n_articles_annotated=0
|gene_in_genetests=Y
|genetests_testable=Y
|nblosum100=3
|autoscore=2
|n_web_uneval=2
}}

{{PMID Auto
|PMID=22740136
|Title=Association of 10q23 with colorectal cancer in a Chinese population.
}}

{{PMID Auto
|PMID=24935391
|Title=Phospholipase C Epsilon 1 (PLCE1 rs2274223A&gt;G, rs3765524C&gt;T and rs7922612C&gt;T) Polymorphisms and Esophageal Cancer Risk in the Kashmir Valley
}}

{{PMID Auto
|PMID=25139097
|Title=Role of novel and GWAS originated PLCE1 genetic variants in susceptibility and prognosis of esophageal cancer patients in northern Indian population
}}
{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | FTDNA2}}
{{on chip | FTDNA}}
{{on chip | Illumina Human 1M}}