{{Rsnum
|rsid=3765534
|Gene=ABCC4
|Chromosome=13
|position=95163161
|Orientation=plus
|GMAF=0.03535
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;T)
|geno3=(T;T)
|Gene_s=ABCC4
}}{{ population diversity
| geno1=(C;C)
| geno2=(C;T)
| geno3=(T;T)
| CEU | 97.3 | 2.7 | 0.0
| HCB | 81.2 | 18.8 | 0.0
| JPT | 68.8 | 24.8 | 6.4
| YRI | 97.9 | 2.1 | 0.0
| ASW | 98.1 | 1.9 | 0.0
| CHB | 81.2 | 18.8 | 0.0
| CHD | 91.6 | 7.5 | 0.9
| GIH | 92.9 | 6.1 | 1.0
| LWK | 98.1 | 1.9 | 0.0
| MEX | 87.5 | 12.5 | 0.0
| MKK | 99.3 | 0.7 | 0.0
| TSI | 96.0 | 4.0 | 0.0
| HapMapRevision=28
}}{{PharmGKB
|RSID=rs3765534
|Name_s=ABCC4:G2269A, ABCC4:E857K
|Gene_s=ABCC4
|Feature=Exon/NonSyn
|Evidence=PubMed ID:18593894
|Annotation=Human lymphocyte cell lines homozygous for the A allele of this variant, common in Japanese populations, exhibit reduced surface membrane levels of ABCC4 protein and increased sensitivity to 6-mercaptopurine toxicity relative to cell lines homozygous for the G allele. The A-allele and G-allele cell lines have similar overall protein expression levels.
|Drugs=mercaptopurine
|Drug Classes=
|Diseases=Neoplasms
|Curation Level=Curated
|PharmGKB Accession ID=PA161925509
}}

{{PMID Auto
|PMID=20393862
|Title=The multidrug-resistance protein 4 polymorphism is a new factor accounting for thiopurine sensitivity in Japanese patients with inflammatory bowel disease
}}

{{PMID Auto
|PMID=18364470
|Title=The human multidrug resistance protein 4 (MRP4, ABCC4): functional analysis of a highly polymorphic gene.
|OA=1
}}

{{PMID Auto
|PMID=18817904
|Title=Japanese population structure, based on SNP genotypes from 7003 individuals compared to other ethnic groups: effects on population-based association studies.
|OA=1
}}

{{PMID Auto
|PMID=20547088
|Title=A Japanese-specific allele in the GALNT11 gene.
}}

{{GET Evidence
|gene=ABCC4
|aa_change=Glu757Lys
|aa_change_short=E757K
|impact=not reviewed
|qualified_impact=Insufficiently evaluated not reviewed
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs3765534
|overall_frequency_n=77
|overall_frequency_d=10756
|overall_frequency=0.00715879
|n_genomes=2
|n_genomes_annotated=0
|n_haplomes=3
|n_articles=0
|n_articles_annotated=0
|nblosum100=0
|autoscore=1
|webscore=N
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | FTDNA2}}
{{on chip | FTDNA}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}