{{Rsnum
|rsid=3775291
|Gene=TLR3
|Chromosome=4
|position=186082920
|Orientation=minus
|ReferenceAllele=C
|MissenseAllele=T
|GMAF=0.2502
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
|Gene_s=TLR3
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;G)
| geno3=(G;G)
| CEU | 13.3 | 47.8 | 38.9
| HCB | 7.4 | 37.5 | 55.1
| JPT | 9.7 | 35.4 | 54.9
| YRI | 0.0 | 2.7 | 97.3
| ASW | 0.0 | 14.0 | 86.0
| CHB | 7.4 | 37.5 | 55.1
| CHD | 13.8 | 48.6 | 37.6
| GIH | 4.0 | 34.7 | 61.4
| LWK | 0.0 | 6.4 | 93.6
| MEX | 12.1 | 46.6 | 41.4
| MKK | 0.0 | 10.9 | 89.1
| TSI | 6.9 | 48.0 | 45.1
| HapMapRevision=28
}}[[rs3775291]] is a SNP in the [[TLR3]] gene associated with an amino acid change in the corresponding protein. In the orientation as shown in dbSNP, the more common [[rs3775291]](G) allele encodes a leucine while the rarer [[rs3775291]](A) allele encodes a phenylalanine.

[[rs3775291]] has been associated with one form of [[age related macular degeneration]] (ARMD), specifically, the form known as "dry" ARMD, also known as geographic atrophy. A study of 3 case-control groups of Americans of European descent, comprising about 900 ARMD patients in total, indicated that having one [[rs3775291]](A) allele reduces the odds of having dry ARMD about 30%, and being a [[rs3775291]](A;A) homozygote cuts your odds by more than half. Specifically, the odds ratio of having dry ARMD with one minor allele is 0.712 (CI: 0.50-1.0), and for two minor alleles, 0.437 ( CI: 0.227-0.839). This was highly significant for the pooled populations (p = 1.24x10eâ€“7) and also in each population independently(p = 0.002-0.005).{{PMID|18753640|OA=1
}}

Results of three independent samples did not confirm previously reported association of [[rs3775291]] with AMD, individually or combined.{{PMID|19628747|OA=1
}}

{{PMID Auto
|PMID=19475618
|Title=TLR3 gene polymorphisms and liver disease manifestations in chronic hepatitis C
}}

{{omim
|desc=MACULAR DEGENERATION, AGE-RELATED, 1; ARMD1
|id=603075
|rsnum=3775291
}}

{{omim
|desc=TOLL-LIKE RECEPTOR 3; TLR3
|id=603029
|rsnum=3775291
}}
{{PMID Auto
|PMID=19741468
|Title=Impact of Polymorphisms of TLR4/CD14 and TLR3 on Acute Rejection in Kidney Transplantation
}}

{{PharmGKB
|RSID=rs3775291
|Name_s=TLR3: P412L
|Gene_s=TLR3
|Feature=
|Evidence=PubMed ID:18325643
|Annotation=Heterozygots for this variant in the TLR3 gene were associated with low antibody and lymphoproliferative responses (p <or= 0.02) to measles vaccination.
|Drugs=
|Drug Classes=MEASLES VACCINES
|Diseases=
|Curation Level=Curated
|PharmGKB Accession ID=PA164925712
}}

{{PharmGKB
|RSID=rs3775291
|Name_s=TLR3: L412F
|Gene_s=TLR3
|Feature=
|Evidence=PubMed ID:18753640
|Annotation=The T allele at rs3775291 in the TLR3 gene was associated with protection against geographic atrophy.
|Drugs=
|Drug Classes=
|Diseases=
|Curation Level=Curated
|PharmGKB Accession ID=PA162355800
}}
{{PMID Auto
|PMID=21239167
|Title=TLR-3 polymorphism is an independent prognostic marker for stage II colorectal cancer
}}

{{PMID Auto
|PMID=21712495
|Title=Toll-like receptor 3 C1234T may protect against geographic atrophy through decreased dsRNA binding capacity
}}

{{PMID Auto
|PMID=22174453
|Title=A Common Polymorphism in TLR3 Confers Natural Resistance to HIV-1 Infection
}}

{{PMID Auto
|PMID=22205660
|Title=Single nucleotide polymorphisms in the Toll-like receptor 3 and CD44 genes are associated with persistence of vaccine-induced immunity to the serogroup C meningococcal conjugate vaccine
|OA=1
}}

{{PMID|15726497|OA=1
}} Gene-environment interaction effects on the development of immune responses in the 1st year of life.

{{PMID|18385087}} Toll-like receptor polymorphisms and age-related macular degeneration.

{{PMID|18598732|OA=1
}} Vaccine immunogenetics: bedside to bench to population.

{{PMID|18847302|OA=1
}} Personalized vaccines: the emerging field of vaccinomics.

{{PMID|19016379}} Association of toll-like receptor 3 gene polymorphism with subacute sclerosing panencephalitis.

{{PMID|19026761|OA=1
}} Molecular pathology of age-related macular degeneration.

{{PMID|19259132|OA=1
}} Multilocus analysis of age-related macular degeneration.

{{PMID|19505919|OA=1
}} Toll-like receptor signaling pathway variants and prostate cancer mortality.

{{PMID|21079408}} Toll-like receptor 3 polymorphism rs3775291 is not associated with choroidal neovascularization or polypoidal choroidal vasculopathy in Chinese subjects.

{{PMID|21216866|OA=1
}} A functional Toll-like receptor 3 gene (TLR3) may be a risk factor for tick-borne encephalitis virus (TBEV) infection.

{{PMID|21609242}} Age-related macular degeneration-susceptibility single nucleotide polymorphisms in a han chinese control population.

{{PMID|21872627}} Association of polymorphisms in TLR genes and in genes of the Toll-like receptor signaling pathway with cancer risk.

{{PMID Auto
|PMID=22552940
|Title=Polymorphisms in Toll-like receptor 3 confer natural resistance to human herpes simplex virus type 2 infection
}}

{{GET Evidence
|gene=TLR3
|aa_change=Leu412Phe
|aa_change_short=L412F
|impact=pharmacogenetic
|qualified_impact=Insufficiently evaluated pharmacogenetic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs3775291
|overall_frequency_n=2294
|overall_frequency_d=10758
|overall_frequency=0.213237
|n_genomes=15
|n_genomes_annotated=0
|n_haplomes=18
|n_articles=3
|n_articles_annotated=3
|qualityscore_in_vitro=3
|qualityscore_case_control=2
|in_pharmgkb=Y
|pph2_score=0.991
|nblosum100=0
|autoscore=2
|webscore=N
}}

{{PMID Auto
|PMID=23576520
|Title=Genetic Polymorphisms in Host Innate Immune Sensor Genes and the Risk of Nasopharyngeal Carcinoma in North Africa
|OA=1
}}

{{PMID Auto
|PMID=23962581
|Title=Association betweenTLR3 rs3775291 and resistance to HIV among highly exposed Caucasian intravenous drug users
}}

{{PMID Auto
|PMID=24028589
|Title=TLR2, TLR3, TLR4 and CD14 gene polymorphisms associated with oral lichen planus risk
}}

{{PMID Auto
|PMID=23466493
|Title=Association of common single-nucleotide polymorphisms in innate immune genes with differences in TLR-induced cytokine production in neonates
}}

{{PMID Auto
|PMID=24064706
|Title=Polymorphisms within Toll-like receptors are associated with systemic lupus erythematosus in a cohort of Danish females
}}

{{PMID Auto
|PMID=24621100
|Title=A Polymorphism in Melanoma Differentiation-associated Gene 5 May Be a Risk Factor for Enterovirus 71 Infection
}}

{{ClinVar
|ALT=T
|CAF=0.7498; 0.2502
|CHROM=4
|CLNACC=RCV000034357.2
|CLNALLE=1
|CLNDBN=Congenital human immunodeficiency virus
|CLNDSDB=MedGen:OMIM
|CLNDSDBID=C1836230:609423
|CLNHGVS=NC_000004.11:g.187004074C>T
|CLNSIG=5
|CLNSRC=OMIM Allelic Variant
|CLNSRCID=603029.0002
|COMMON=1
|Disease=Congenital human immunodeficiency virus
|FwdALT=A
|FwdREF=G
|GENEINFO=TLR3:7098
|GENE_ID=7098
|GENE_NAME=TLR3
|REF=C
|RSPOS=187004074
|Reversed=1
|SAO=0
|SSR=0
|Tags=RV;PM;PMC;S3D;SLO;VLD;G5;HD;GNO;KGPhase1;KGPilot123;KGPROD;OTHERKG;PH3;LSD;OM
|VC=SNV
|VP=0x05036800000015051f110100
|WGT=0
|dbSNPBuildID=107
|rsid=3775291
}}

{{PMID Auto
|PMID=25226020
|Title=Polymorphisms in Chemokine Receptor 5 and Toll-Like Receptor 3 Genes Are Risk Factors for Clinical Tick-Borne Encephalitis in the Lithuanian Population
}}
{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Affy GenomeWide 6}}
{{on chip | FTDNA2}}
{{on chip | FTDNA}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}