{{Rsnum
|rsid=3780126
|Gene=GGH
|Chromosome=8
|position=63037353
|Orientation=minus
|GMAF=0.4105
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;T)
|geno3=(T;T)
|Gene_s=GGH
}}{{ population diversity
| geno1=(C;C)
| geno2=(C;T)
| geno3=(T;T)
| CEU | 35.4 | 47.8 | 16.8
| HCB | 45.3 | 46.0 | 8.8
| JPT | 47.8 | 43.4 | 8.8
| YRI | 16.4 | 50.7 | 32.9
| ASW | 19.3 | 45.6 | 35.1
| CHB | 45.3 | 46.0 | 8.8
| CHD | 41.3 | 43.1 | 15.6
| GIH | 19.8 | 52.5 | 27.7
| LWK | 18.2 | 52.7 | 29.1
| MEX | 34.5 | 46.6 | 19.0
| MKK | 36.4 | 45.5 | 18.2
| TSI | 40.2 | 45.1 | 14.7
| HapMapRevision=28
}}{{PharmGKB
|RSID=rs3780126
|Name_s=GGH: IVS1, 1307C>T, c.109+1307G>C
|Gene_s=GGH
|Feature=
|Evidence=PubMed ID:19841321
|Annotation=Risk or phenotype-associated allele: T. Phenotype: The C allele was correlated with increased overall survival (CC vs. CT vs. TT: 15.4, 7.3, 4.8 months) given combined pemetrexed/bevacizumab treatment (p = 0.04), and lymphopenia as an adverse drug effect (p <= 0.05). Study size: from a study using 48 patients with metastatic or stage IIIB nonsquamous non-small-cell lung cancer patients. Significance metric(s): log-rank p = 0.04, p <= 0.05. Type of association: CO, GN
|Drugs=bevacizumab; pemetrexed
|Drug Classes=
|Diseases=Carcinoma, Non-Small-Cell Lung
|Curation Level=Curated
|PharmGKB Accession ID=PA165109563
}}

{{PMID Auto
|PMID=22018726
|Title=Genetic variation in folylpolyglutamate synthase and gamma-glutamyl hydrolase and plasma homocysteine levels in the Singapore Chinese Health Study
|OA=1
}}

{{GET Evidence
|impact=pharmacogenetic
|qualified_impact=Insufficiently evaluated pharmacogenetic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs3780126
|overall_frequency_n=49
|overall_frequency_d=128
|overall_frequency=0.382812
|n_genomes=35
|n_genomes_annotated=0
|n_haplomes=46
|n_articles=1
|n_articles_annotated=0
|in_pharmgkb=Y
|autoscore=1
|webscore=N
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | FTDNA2}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}