{{Rsnum
|rsid=3780422
|Gene=GABBR2
|Chromosome=9
|position=98380522
|Orientation=minus
|GMAF=0.3903
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
|Gene_s=GABBR2
}}{{PMID|15759211|OA=1
}} Associated with [[nicotine Dependence]] as part of several haplotypes, based on a study of 1,000+ subjects including both African-Americans and European-Americans.

The risk haplotype varies between populations. Among African-Americans, the haplotype C-C-G of [[rs2491397]]-[[rs2184026]]-[[rs3750344]] had a significant positive association with [[nicotine dependence]]. Among European-Americans, for [[rs1435252]]-[[rs3780422]]-[[rs2779562]]-[[rs3750344]], the C-A-C-A haplotype was positively associated with [[nicotine dependence]] while the T-A-T-A haplotype was negatively associated.{{PMID|15759211|OA=1
}}

{{omim
|id=607340
|desc=GAMMA-AMINOBUTYRIC ACID B RECEPTOR 2; GABBR2
|rsnum=3780422
}}

{{omim
|id=607340
|rsnum=3780422
|variant=0002
}}

{{omim
|id=607340
|rsnum=3780422
|variant=0003
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | HumanOmni1Quad}}