{{Rsnum
|rsid=3784709
|Gene=MAP2K5
|Chromosome=15
|position=67779937
|Orientation=plus
|GMAF=0.4711
|Gene_s=MAP2K5
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;T)
|geno3=(T;T)
}}
{{ population diversity
| geno1=(C;C)
| geno2=(C;T)
| geno3=(T;T)
| CEU | 46.9 | 47.8 | 5.3
| HCB | 7.3 | 46.0 | 46.7
| JPT | 9.7 | 45.1 | 45.1
| YRI | 36.7 | 51.0 | 12.2
| ASW | 42.1 | 40.4 | 17.5
| CHB | 7.3 | 46.0 | 46.7
| CHD | 10.1 | 40.4 | 49.5
| GIH | 30.7 | 43.6 | 25.7
| LWK | 48.2 | 37.3 | 14.5
| MEX | 13.8 | 46.6 | 39.7
| MKK | 51.3 | 41.0 | 7.7
| TSI | 46.1 | 41.2 | 12.7
| HapMapRevision=28
}}[[rs3784709]], a SNP located in a region of chromosome 15q, has been linked to a lower frequency of [[restless legs syndrome]], a common sleep disorder, with an overall odds ratio of 0.71 (CI: 0.60-0.83) for the (T) minor allele. {{PMID|17637780}}
{{ neighbor
| rsid = 4489954
| distance = 200
}}

{{PharmGKB
|RSID=rs3784709
|Name_s=
|Gene_s=MAP2K5
|Feature=
|Evidence=PubMed ID:17637780
|Annotation=In replicated GWAS case-control studies of Caucasian(European and French-Canadian) familial and sporadic RLS, the C allele of rs3784709 was significantly associated with Restless Legs Syndrome.
|Drugs=
|Drug Classes=
|Diseases=Restless Legs Syndrome
|Curation Level=Curated
|PharmGKB Accession ID=PA162355632
}}

{{PMID Auto
|PMID=19279021
|Title=Replication of restless legs syndrome loci in three European populations.
|OA=1
}}

{{GET Evidence
|impact=pharmacogenetic
|qualified_impact=Insufficiently evaluated pharmacogenetic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs3784709
|overall_frequency_n=56
|overall_frequency_d=128
|overall_frequency=0.4375
|n_genomes=38
|n_genomes_annotated=0
|n_haplomes=51
|n_articles=1
|n_articles_annotated=0
|in_pharmgkb=Y
|autoscore=1
|webscore=N
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Affy GenomeWide 6}}
{{on chip | FTDNA2}}
{{on chip | FTDNA}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}