{{Rsnum
|rsid=3788853
|Gene=XPNPEP2
|Chromosome=X
|position=129736814
|Orientation=minus
|GMAF=0.24
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(G;G)
|geno2=(G;T)
|geno3=(T;T)
}}{{ population diversity
| geno1=(G;G)
| geno2=(G;T)
| geno3=(T;T)
| CEU | 64.3 | 18.8 | 17.0
| HCB | 62.0 | 21.2 | 16.8
| JPT | 55.8 | 24.8 | 19.5
| YRI | 69.0 | 15.2 | 15.9
| ASW | 66.7 | 19.3 | 14.0
| CHB | 62.0 | 21.2 | 16.8
| CHD | 61.5 | 22.0 | 16.5
| GIH | 71.3 | 18.8 | 9.9
| LWK | 61.5 | 17.4 | 21.1
| MEX | 56.9 | 24.1 | 19.0
| MKK | 66.5 | 20.6 | 12.9
| TSI | 82.8 | 12.1 | 5.1
| HapMapRevision=28
}}A form of this snp, located upstream of the [[XPNPEP2]] gene on the X chromosome, may cause susceptibility to [[angioedema|skin swelling]] when taking medicines called [[ACE Inhibitors]]. {{PMID|16175507|OA=1
}}

Also known as -2399C/A in the literature; however in SNPedia, where the orientation of the corresponding dbSNP entry is recognized as primary, this is G/T.
  
After noticing the association of this SNP with the phenotype, the authors genotyped 20 independent AE-ACEi cases and 60 unrelated, matching controls for this SNP. The T allele was present in 8 of the 20 AE patients; and by allele counting, the T allele was found at a frequency of 11.1% in the control population and 27.3% in their AE-ACEi cases.
 
*See also [http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=300145 OMIM 300145]

{{omim
|id=300145
|rsnum=3788853
|variant=0001
}}

{{PMID Auto
|PMID=19178938
|Title=Genetic analysis of Factor XII and bradykinin catabolic enzymes in a family with estrogen-dependent inherited angioedema.
}}

{{PMID Auto
|PMID=20625347
|Title=Sex-dependent and race-dependent association of XPNPEP2 C-2399A polymorphism with angiotensin-converting enzyme inhibitor-associated angioedema.
|OA=1
}}

{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Affy GenomeWide 6}}
{{on chip | HumanOmni1Quad}}