{{Rsnum
|rsid=3789604
|Gene=RSBN1
|Chromosome=1
|position=113812320
|Orientation=plus
|ReferenceAllele=A
|GMAF=0.1593
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(G;G)
|geno2=(G;T)
|geno3=(T;T)
|Gene_s=RSBN1
}}{{ population diversity
| geno1=(G;G)
| geno2=(G;T)
| geno3=(T;T)
| CEU | 6.7 | 25.0 | 68.3
| HCB | 7.9 | 26.3 | 65.8
| JPT | 4.5 | 36.4 | 59.1
| YRI | 0.0 | 5.0 | 95.0
| ASW | 0.0 | 0.0 | 0.0
| CHB | 7.9 | 26.3 | 65.8
| CHD | 0.0 | 0.0 | 0.0
| GIH | 0.0 | 0.0 | 0.0
| LWK | 0.0 | 0.0 | 0.0
| MEX | 0.0 | 0.0 | 0.0
| MKK | 0.0 | 0.0 | 0.0
| TSI | 0.0 | 0.0 | 0.0
| HapMapRevision=28
}}[[rs3789604]] is associated with increased susceptibility to [[rheumatoid arthritis]], based on a study of ~1,000 Caucasian individuals. The odds ratio is 1.55x for (G;T) heterozygotes and 1.73x for (G;G) homozygotes.{{PMID|16175503|OA=1
}}

However, in a Japanese population, the other allele, [[rs3789604]](T), is associated with increased risk (odds ratio 1.45, p=0.0085) for [[Graves' disease]] (GD).{{PMID|18578611}}

{{PMID Auto
|PMID=18923449
|Title=Further genetic evidence for three psoriasis-risk genes: ADAM33, CDKAL1, and PTPN22
}}

{{PMID Auto
|PMID=19438904
|Title=Clinical associations of the genetic variants of CTLA-4, Tg, TSHR, PTPN22, PTPN12 and FCRL3 in patients with Graves' disease
}}

{{PMID Auto
|PMID=20510318
|Title=Association of PTPN22 Haplotypes with Type 1 Diabetes in the Japanese Population
}}
{{PMID Auto
|PMID=20615141
|Title=Association of the Protein Tyrosine Phosphatase Nonreceptor 22 Haplotypes with Autoimmune Thyroid Disease in the Japanese Population
}}

{{omim
|id=177900
|rsnum=3789604
}}

{{PMID Auto
|PMID=17135225
|Title=The 620W allele is the PTPN22 genetic variant conferring susceptibility to RA in a Dutch population.
}}

{{PMID Auto
|PMID=18341666
|Title=Polymorphisms in the PTPN22 region are associated with psoriasis of early onset.
|OA=1
}}

{{PMID Auto
|PMID=18466461
|Title=Meta-genetic association of rheumatoid arthritis and PTPN22 using PedGenie 2.1.
|OA=1
}}

{{PMID Auto
|PMID=18466531
|Title=Case-control association analysis of rheumatoid arthritis with candidate genes using related cases.
|OA=1
}}

{{PMID Auto
|PMID=18466575
|Title=Comparison of the power of haplotype-based versus single- and multilocus association methods for gene x environment (gene x sex) interactions and application to gene x smoking and gene x sex interactions in rheumatoid arthritis.
|OA=1
}}

{{PMID Auto
|PMID=19180477
|Title=Genetic risk factors for rheumatoid arthritis differ in Caucasian and Korean populations.
|OA=1
}}

{{PMID Auto
|PMID=19638187
|Title=Genetic susceptibility to psoriasis: an emerging picture.
|OA=1
}}

{{PMID Auto
|PMID=22396730
|Title=No association of PTPN22 polymorphisms with susceptibility to ocular Behcet's disease in two Chinese Han populations.
|OA=1
}}

{{PMID Auto
|PMID=25073032
|Title=Association Between a Gain-of-Function Variant of PTPN22 and Rejection in Liver Transplantation
}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | HumanOmni1Quad}}