{{Rsnum
|rsid=3790567
|Gene=IL12RB2
|Chromosome=1
|position=67356694
|Orientation=plus
|GMAF=0.3604
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
|Gene_s=IL12RB2
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;G)
| geno3=(G;G)
| CEU | 2.7 | 46.9 | 50.4
| HCB | 6.6 | 37.2 | 56.2
| JPT | 2.7 | 38.1 | 59.3
| YRI | 62.6 | 33.3 | 4.1
| ASW | 38.6 | 47.4 | 14.0
| CHB | 6.6 | 37.2 | 56.2
| CHD | 5.5 | 33.9 | 60.6
| GIH | 7.9 | 29.7 | 62.4
| LWK | 69.1 | 25.5 | 5.5
| MEX | 10.3 | 29.3 | 60.3
| MKK | 62.2 | 32.7 | 5.1
| TSI | 10.8 | 39.2 | 50.0
| HapMapRevision=28
}}[http://blog.23andme.com/2009/05/20/snpwatch-researchers-link-variations-in-immune-system-genes-with-primary-biliary-cirrhosis/ 23andMe blog] 
*Each G at [[rs2856683]] increased the odds of [[primary biliary cirrhosis]] by 1.75x.
*Each G at [[rs6441286]] increased the odds of [[primary biliary cirrhosis]] by 1.54x.   
*Each A at [[rs3790567]] increased the odds of [[primary biliary cirrhosis]] by 1.51x.

{{PMID Auto
|PMID=19458352
|Title=Primary Biliary Cirrhosis Associated with HLA, IL12A, and IL12RB2 Variants
|OA=1
}}

{{PharmGKB
|RSID=rs3790567
|Name_s=
|Gene_s=IL12RB2
|Feature=
|Evidence=PubMed ID:19458352
|Annotation=A GWAS of 2072 Canadian and U.S. subjects (536 patients with primary biliary cirrhosis and 1536 controls) showed that primary biliary cirrhosis was significantly and reproducibly associated with this SNP (rs3790567) at the IL12RB2 locus (P=2.76x10(-11); odds ratio, 1.51).
|Drugs=
|Drug Classes=
|Diseases=Liver Cirrhosis, Biliary
|Curation Level=Curated
|PharmGKB Accession ID=PA164918146
}}

{{PMID Auto GWAS
|PMID=20639880
|Trait=Primary biliary cirrhosis
|Title=Genome-wide meta-analyses identify three loci associated with primary biliary cirrhosis
|RiskAllele=A
|Pval=8E-12
|OR=1.48
|ORtxt=[NR]
|OA=1
}}

{{PMID Auto
|PMID=21285166
|Title=Role of rs1343151 IL23R and rs3790567 IL12RB2 Polymorphisms in Biopsy-proven Giant Cell Arteritis
}}

{{omim
|id=613008
|rsnum=3790567
}}

{{PMID|18598732|OA=1
}} Vaccine immunogenetics: bedside to bench to population.

{{PMID|21506939}} Replicated association of 17q12-21 with susceptibility of primary biliary cirrhosis in a Japanese cohort.

{{PMID|22076442|OA=1
}} A GWAS follow-up study reveals the association of the IL12RB2 gene with systemic sclerosis in Caucasian populations.

{{GET Evidence
|impact=pathogenic
|qualified_impact=Insufficiently evaluated pathogenic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs3790567
|overall_frequency_n=64
|overall_frequency_d=128
|overall_frequency=0.5
|n_genomes=37
|n_genomes_annotated=0
|n_haplomes=52
|n_articles=1
|n_articles_annotated=0
|in_gwas=Y
|in_pharmgkb=Y
|autoscore=2
|webscore=N
}}

[[Primary Biliary Cirrhosis: Preliminary Research]]

{{PMID Auto
|PMID=23009887
|Title=Impact of cytokine and cytokine receptor gene polymorphisms on cellular immunity after smallpox vaccination.
|OA=1
}}

{{PMID Auto
|PMID=24997981
|Title=Association study between interleukin-12 receptor β1/β2 genes and allergic rhinitis in the Chinese Han population
}}
{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Affy GenomeWide 6}}
{{on chip | Illumina Human 1M}}