{{Rsnum
|rsid=3792876
|Gene=SLC22A4
|Chromosome=5
|position=132301616
|Orientation=plus
|GMAF=0.1304
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;T)
|geno3=(T;T)
|Gene_s=SLC22A4
}}{{ population diversity
| geno1=(C;C)
| geno2=(C;T)
| geno3=(T;T)
| CEU | 82.3 | 15.9 | 1.8
| HCB | 60.6 | 32.1 | 7.3
| JPT | 46.0 | 43.4 | 10.6
| YRI | 88.4 | 11.6 | 0.0
| ASW | 89.5 | 8.8 | 1.8
| CHB | 60.6 | 32.1 | 7.3
| CHD | 57.8 | 33.0 | 9.2
| GIH | 84.2 | 15.8 | 0.0
| LWK | 90.0 | 9.1 | 0.9
| MEX | 89.7 | 10.3 | 0.0
| MKK | 94.9 | 5.1 | 0.0
| TSI | 85.3 | 13.7 | 1.0
| HapMapRevision=28
}}NOTE: information for [[rs1050152]] was accidentally entered for this SNP, [[rs3792876]]. Although the SNPs are in the same gene, the original reference does not specifically refer to [[rs3792876]] and the degree of linkage has not been confirmed. 

[[rs1051052]], a SNP in the [[SLC22A4]] gene known as L503F, has been associated with an autoimmune disease, in this case, [[Crohn's disease]], odds ratio = 2.1 (CI = 1.31â€“3.39, p = 0.002), based on a study of 203 cases and 200 controls. The risk allele is [[rs1050152]](T).{{PMID|15107849}}

A nearby SNP in the promoter region of the [[SLC22A5]] gene defines a haplotype along with [[rs3792876]], with odds ratio reported as similar for either SNP or the haplotype.{{PMID|15107849}}

{{PMID|18709696}} [[rs2073838]] and [[rs3792876]] replicated for [[rheumatoid arthritis]] in Japanese, but not Caucasian populations.

{{PMID|18087673}} [[rs3792876]] failed to showed a statistically significant association with [[rheumatoid arthritis]]

{{PharmGKB
|RSID=rs3792876
|Name_s=
|Gene_s=SLC22A4
|Feature=
|Evidence=PubMed ID:18709696
|Annotation=In a replication study in a Japanese population and a metaanalysis of 9 studies confirmed an association of this SNP in the SLC22A4 gene with rheumatoid arthritis in Japanese population. The associations in Caucasian studies were not significant.
|Drugs=
|Drug Classes=
|Diseases=Arthritis, Rheumatoid
|Curation Level=Curated
|PharmGKB Accession ID=PA162191341
}}

{{PMID Auto
|PMID=15751072
|Title=Investigation of the SLC22A4 gene (associated with rheumatoid arthritis in a Japanese population) in a United Kingdom population of rheumatoid arthritis patients.
}}

{{PMID Auto
|PMID=16519819
|Title=Analysis of polymorphisms in 16 genes in type 1 diabetes that have been associated with other immune-mediated diseases.
|OA=1
}}

{{PMID Auto
|PMID=16796743
|Title=Evidence for the association of the SLC22A4 and SLC22A5 genes with type 1 diabetes: a case control study.
|OA=1
}}

{{PMID Auto
|PMID=17476680
|Title=Genetic susceptibility has a more important role in pediatric-onset Crohn's disease than in adult-onset Crohn's disease.
}}

{{PMID Auto
|PMID=19840389
|Title=Identification of a haplotype block in the 5q31 cytokine gene cluster associated with the susceptibility to severe malaria.
|OA=1
}}

{{PMID Auto
|PMID=19956108
|Title=Analysis of 55 autoimmune disease and type II diabetes loci: further confirmation of chromosomes 4q27, 12q13.2 and 12q24.13 as type I diabetes loci, and support for a new locus, 12q13.3-q14.1.
|OA=1
}}

{{PMID Auto
|PMID=20444268
|Title=Peripheral blood gene expression patterns discriminate among chronic inflammatory diseases and healthy controls and identify novel targets.
|OA=1
}}

{{GET Evidence
|impact=pharmacogenetic
|qualified_impact=Insufficiently evaluated pharmacogenetic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs3792876
|overall_frequency_n=11
|overall_frequency_d=128
|overall_frequency=0.0859375
|n_genomes=11
|n_genomes_annotated=0
|n_haplomes=14
|n_articles=3
|n_articles_annotated=3
|in_pharmgkb=Y
|autoscore=1
|webscore=N
|summary_short=May be associated with Crohn disease.
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | FTDNA2}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}