{{Rsnum
|rsid=3793917
|Gene=HTRA1
|Chromosome=10
|position=124219275
|Orientation=minus
|GMAF=0.2796
|Assembly=GRCh37
|GenomeBuild=37.1
|dbSNPBuild=131
|geno1=(C;C)
|geno2=(C;G)
|geno3=(G;G)
}}
{{ population diversity
| geno1=(C;C)
| geno2=(C;G)
| geno3=(G;G)
| CEU | 3.2 | 36.5 | 60.3
| HCB | 15.9 | 61.4 | 22.7
| JPT | 18.6 | 51.2 | 30.2
| YRI | 8.2 | 45.9 | 45.9
| ASW | 0.0 | 0.0 | 0.0
| CHB | 15.9 | 61.4 | 22.7
| CHD | 0.0 | 0.0 | 0.0
| GIH | 0.0 | 0.0 | 0.0
| LWK | 0.0 | 0.0 | 0.0
| MEX | 0.0 | 0.0 | 0.0
| MKK | 0.0 | 0.0 | 0.0
| TSI | 0.0 | 0.0 | 0.0
| HapMapRevision=28
}}[http://www.nature.com/ng/journal/v40/n7/full/ng.170.html nature] [[age related macular degeneration]] is associated with five highly correlated SNPs ([[rs10490924]], [[rs3750848]], [[rs3793917]], [[rs11200638]] and [[rs932275]]; r2 < 0.88) showed strongest association with AMD (2.72 < OR < 2.86)

{{PMID Auto
|PMID=19933195
|Title=Analysis of six genetic risk factors highly associated with AMD in the region surrounding ARMS2 and HTRA1 on chromosome 10q26
}}

{{PMID Auto GWAS
|PMID=20385819
|Trait=Age-related macular degeneration
|Title=Genetic variants near TIMP3 and high-density lipoprotein-associated loci influence susceptibility to age-related macular degeneration
|RiskAllele=G
|Pval=4E-60
|OR=3.40
|ORtxt=[2.94-3.94]
|OA=1
}}

{{PMID|17884985|OA=1
}} A variant of mitochondrial protein LOC387715/ARMS2, not HTRA1, is strongly associated with age-related macular degeneration.

{{PMID|20140183|OA=1
}} Genetic and functional dissection of HTRA1 and LOC387715 in age-related macular degeneration.

{{PMID|20445115}} An intergenic region between the tagSNP rs3793917 and rs11200638 in the HTRA1 gene indicates association with age-related macular degeneration.

{{PMID|21878851}} Association between high-risk disease loci and response to anti-vascular endothelial growth factor treatment for wet age-related macular degeneration.

{{PMID|22618592}} Association of genetic polymorphisms and age-related macular degeneration in chinese population.

{{PMID Auto
|PMID=23582991
|Title=Genetic Influences on the Outcome of Anti-Vascular Endothelial Growth Factor Treatment in Neovascular Age-related Macular Degeneration
}}

{{PMID Auto GWAS
  |PMID=23326517
  |Trait=Age-related macular degeneration
  |Title=Insights into the genetic architecture of early stage age-related macular degeneration: a genome-wide association study meta-analysis.
  |RiskAllele=
  |Pval=4E-24
  |OR=1.45
  |ORtxt=[1.35-1.56]
  |OA=1
}}

{{PMID Auto
|PMID=24013816
|Title=Cumulative association between age-related macular degeneration and less studied genetic variants in PLEKHA1/ARMS2/HTRA1: a meta and gene-cluster analysis
}}

{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | FTDNA2}}
{{on chip | FTDNA}}