{{Rsnum
|rsid=3800373
|Gene=FKBP5
|Chromosome=6
|position=35574699
|Orientation=minus
|GMAF=0.2971
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(G;G)
|geno2=(G;T)
|geno3=(T;T)
|Gene_s=FKBP5,LOC101929309
}}{{ population diversity
| geno1=(G;G)
| geno2=(G;T)
| geno3=(T;T)
| CEU | 2.7 | 43.4 | 54.0
| HCB | 4.4 | 39.4 | 56.2
| JPT | 1.8 | 29.2 | 69.0
| YRI | 24.5 | 51.0 | 24.5
| ASW | 21.1 | 52.6 | 26.3
| CHB | 4.4 | 39.4 | 56.2
| CHD | 10.1 | 31.2 | 58.7
| GIH | 13.9 | 44.6 | 41.6
| LWK | 15.5 | 42.7 | 41.8
| MEX | 1.7 | 36.2 | 62.1
| MKK | 19.9 | 48.7 | 31.4
| TSI | 12.7 | 42.2 | 45.1
| HapMapRevision=28
}}{{PMID|18349090|OA=1
}} [[rs9296158]] [[rs3800373]] [[rs1360780]] [[rs9470080]] linked with the severity of child abuse to predict level of adult [[PTSD]] symptoms after correcting for multiple testing.

{{PMID Auto
|PMID=19199039
|Title=Differential expression of immunophilins FKBP51 and FKBP52 in the frontal cortex of HIV-infected patients with major depressive disorder
|OA=1
}}

{{PharmGKB
|RSID=rs3800373
|Name_s=
|Gene_s=FKBP5
|Feature=
|Evidence=PubMed ID:15565110; PubMed ID:18349090; PubMed ID:18597649
|Annotation=This variant is associated with higher chance of response to anti-depressant drugs.
|Drugs=desipramine; fluoxetine; mirtazapine; venlafaxine
|Drug Classes=
|Diseases=Depression
|Curation Level=Curated
|PharmGKB Accession ID=PA162168153
}}

{{PMID Auto
|PMID=20090668
|Title=Interaction of FKBP5, a Stress-Related Gene, with Childhood Trauma Increases the Risk for Attempting Suicide
|OA=1
}}

{{PMID Auto
|PMID=20008943
|Title=Association of FKBP5 polymorphisms with suicidal events in the Treatment of Resistant Depression in Adolescents (TORDIA) study
|OA=1
}}

{{PMID Auto
|PMID=20393453
|Title=Interaction of FKBP5 with Childhood Adversity on Risk for Post-Traumatic Stress Disorder
|OA=1
}}
{{PMID Auto
|PMID=20709156
|Title=Meta-analysis of FKBP5 gene polymorphisms association with treatment response in patients with mood disorders
}}

{{PMID Auto
|PMID=22134958
|Title=Relationship between FKBP5 polymorphisms and depression symptoms among kidney transplant recipients
}}

{{PMID Auto
|PMID=15637659
|Title=Linkage disequilibrium patterns and tagSNP transferability among European populations.
|OA=1
}}

{{PMID Auto
|PMID=17081296
|Title=Is FKBP5 a genetic marker of affective psychosis? A case control study and analysis of disease related traits.
|OA=1
}}

{{PMID Auto
|PMID=18191112
|Title=The FKBP5-gene in depression and treatment response--an association study in the Sequenced Treatment Alternatives to Relieve Depression (STAR*D) Cohort.
|OA=1
}}

{{PMID Auto
|PMID=19455174
|Title=Psychobiology and molecular genetics of resilience.
|OA=1
}}

{{PMID Auto
|PMID=19676097
|Title=FKBP5 polymorphisms and antidepressant response in geriatric depression.
|OA=1
}}

{{PMID Auto
|PMID=19750552
|Title=Risk and resilience: genetic and environmental influences on development of the stress response.
|OA=1
}}

{{PMID Auto
|PMID=20726698
|Title=Correlation of major depressive disorder symptoms with FKBP5 but not FKBP4 expression in human immunodeficiency virus-infected individuals.
|OA=1
}}

{{PMID Auto
|PMID=21112363
|Title=Association of FKBP5 gene haplotypes with completed suicide in the Japanese population.
}}

{{PMID Auto
|PMID=21172166
|Title=Pharmacogenetics of antidepressant response.
|OA=1
}}

{{PMID Auto
|PMID=21448414
|Title=Molecular mechanism of glucocorticoid resistance in inflammatory bowel disease.
|OA=1
}}

{{PMID Auto
|PMID=21788965
|Title=Glucocorticoid resistance in Crohn's disease and ulcerative colitis: an association study investigating GR and FKBP5 gene polymorphisms.
}}

{{PMID Auto
|PMID=21978546
|Title=Two HPA axis genes, CRHBP and FKBP5, interact with childhood trauma to increase the risk for suicidal behavior.
|OA=1
}}

{{PMID Auto
|PMID=22213790
|Title=Interaction between FKBP5 and childhood trauma and risk of aggressive behavior.
|OA=1
}}

{{PMID Auto
|PMID=22979952
|Title=FKBP5 AND EMOTIONAL NEGLECT INTERACT TO PREDICT INDIVIDUAL DIFFERENCES IN AMYGDALA REACTIVITY
|OA=1
}}

{{GET Evidence
|impact=pharmacogenetic
|qualified_impact=Insufficiently evaluated pharmacogenetic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs3800373
|overall_frequency_n=83
|overall_frequency_d=128
|overall_frequency=0.648438
|n_genomes=51
|n_genomes_annotated=0
|n_haplomes=77
|n_articles=0
|n_articles_annotated=0
|in_pharmgkb=Y
|autoscore=1
|webscore=N
}}

{{PMID Auto
|PMID=23062294
|Title=The role of limbic system irritability in linking history of childhood maltreatment and psychiatric outcomes in low-income, high-risk women: moderation by FK506 binding protein 5 haplotype.
|OA=1
}}

{{PMID Auto
|PMID=23733030
|Title=Pharmacogenetics in major depression: a comprehensive meta-analysis.
}}

{{PMID Auto
|PMID=24845178
|Title=Stress-related genes and heroin addiction: A role for a functional FKBP5 haplotype
}}

{{PMID Auto
|PMID=24856550
|Title=FKBP5 polymorphism is associated with major depression but not with bipolar disorder
}}
{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | FTDNA2}}
{{on chip | FTDNA}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}