{{Rsnum
|rsid=3802842
|Gene=C11orf93
|Chromosome=11
|position=111300984
|Orientation=plus
|GMAF=0.3136
|Gene_s=C11orf92,C11orf93
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;C)
|geno3=(C;C)
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;C)
| geno3=(C;C)
| CEU | 59.3 | 34.5 | 6.2
| HCB | 37.3 | 47.0 | 15.7
| JPT | 40.7 | 52.2 | 7.1
| YRI | 40.8 | 50.3 | 8.8
| ASW | 35.1 | 52.6 | 12.3
| CHB | 37.3 | 47.0 | 15.7
| CHD | 26.9 | 52.8 | 20.4
| GIH | 65.3 | 28.7 | 5.9
| LWK | 45.5 | 32.7 | 21.8
| MEX | 62.1 | 37.9 | 0.0
| MKK | 39.1 | 45.5 | 15.4
| TSI | 50.0 | 41.2 | 8.8
| HapMapRevision=28
}}[[rs3802842]] is a SNP in a region of ch 11q23.1 that has been associated with some cancers.

IN a study of over 10,000 cases of [[colorectal cancer]], [[rs3802842]](C) was associated with increased risk (odds ratio 1.17, CI: 1.12-1.22, p = 1.08 x 10e-12). Additional SNPs in chromosomal regions 8q21, 8q24, 10p14, 11q, 15q13.3 and 18q21 can be combined additively to produce an overall risk, with an average odds ratio per risk allele of 1.19.{{PMID|18753146}}

{{GWAS Summary
|SNP=rs3802842
|PubMedID=18372901
|Condition=Colorectal cancer
|Gene=Intergenic
|Risk Allele=C
|pValue=6.00E-010
|OR=1.11
|95CI=1.08-1.15
|OA=1
}}

{{omim
|desc=COLORECTAL CANCER, SUSCEPTIBILITY TO, 7; CRCS7
|id=612232
|rsnum=3802842
}}
{{PMID Auto
|PMID=19843678
|Title=Enrichment of Low Penetrance Susceptibility Loci in a Dutch Familial Colorectal Cancer Cohort
}}

{{PharmGKB
|RSID=rs3802842
|Name_s=
|Gene_s=C11orf92
|Feature=
|Evidence=PubMed ID:18372901; Web Resource:http://www.genome.gov/gwastudies/
|Annotation=GWAS Results: Genome-wide association scan identifies a colorectal cancer susceptibility locus on 11q23 and replicates risk loci at 8q24 and 18q21 (Initial Sample Size: 981 cases, 1,002 controls; Replication Sample Size: 16,476 cases, 15,351 controls; Risk Allele: rs3802842-C).
|Drugs=
|Drug Classes=
|Diseases=Colorectal Neoplasms
|Curation Level=Non-Curated
|PharmGKB Accession ID=PA162356761
}}

{{PMID Auto
|PMID=20530476
|Title=Risk of Genome-Wide Association Study-Identified Genetic Variants for Colorectal Cancer in a Chinese Population
}}
{{PMID Auto
|PMID=20659471
|Title=Genetic Heterogeneity in Colorectal Cancer Associations in Americans of African vs. European Descent
|OA=1
}}
{{PMID Auto
|PMID=21097774
|Title=Colorectal cancer susceptibility loci on chromosome 8q23.3 and 11q23.1 as modifiers for disease expression in lynch syndrome
}}
{{PMID Auto
|PMID=21119214
|Title=Colorectal Cancer Susceptibility Loci in a Population-Based Study: Associations with Morphological Parameters
|OA=1
}}

{{PMID Auto GWAS
|PMID=21761138
|Trait=None
|Title=Meta-analysis of new genome-wide association studies of colorectal cancer risk.
|RiskAllele=
|Pval=4E-7
|OR=1.1400
|ORtxt=[1.08-1.20]
|OA=1
}}

{{PMID Auto
|PMID=22367214
|Title=Characterization of gene-environment interactions for colorectal cancer susceptibility loci
|OA=1
}}

{{PMID Auto
|PMID=22457859
|Title=Single nucleotide polymorphisms in colorectal cancer: associations with tumor site and TNM stage
}}

{{PMID Auto
|PMID=19010329
|Title=Chromosome 8q23.3 and 11q23.1 variants modify colorectal cancer risk in Lynch syndrome.
}}

{{PMID Auto
|PMID=19011631
|Title=Meta-analysis of genome-wide association data identifies four new susceptibility loci for colorectal cancer.
|OA=1
}}

{{PMID Auto
|PMID=20501757
|Title=Low-penetrance susceptibility variants in familial colorectal cancer.
|OA=1
}}

{{PMID Auto
|PMID=20648012
|Title=Association studies on 11 published colorectal cancer risk loci.
|OA=1
}}

{{PMID Auto
|PMID=21071539
|Title=Generalizability and epidemiologic characterization of eleven colorectal cancer GWAS hits in multiple populations.
|OA=1
}}

{{PMID Auto
|PMID=21314996
|Title=Systematic search for enhancer elements and somatic allelic imbalance at seven low-penetrance colorectal cancer predisposition loci.
|OA=1
}}

{{PMID Auto
|PMID=22045029
|Title=Relationship between 16 susceptibility loci and colorectal cancer phenotype in 3146 patients.
}}

{{PMID Auto
|PMID=22235025
|Title=Susceptibility genetic variants associated with early-onset colorectal cancer.
}}

{{PMID Auto
|PMID=23029024
|Title=Replication Study in Chinese Population and Meta-Analysis Supports Association of the 11q23 Locus with Colorectal Cancer
|OA=1
}}

{{GET Evidence
|impact=pathogenic
|qualified_impact=Insufficiently evaluated pathogenic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs3802842
|overall_frequency_n=73
|overall_frequency_d=124
|overall_frequency=0.58871
|n_genomes=47
|n_genomes_annotated=0
|n_haplomes=60
|n_articles=0
|n_articles_annotated=0
|in_gwas=Y
|in_pharmgkb=Y
|autoscore=2
|webscore=N
}}

{{PMID Auto
|PMID=23359760
|Title=Single-nucleotide polymorphism associations for colorectal cancer in southern chinese population
|OA=1
}}

{{PMID Auto GWAS
  |PMID=23266556
  |Trait=Colorectal cancer
  |Title=Identification of Genetic Susceptibility Loci for Colorectal Tumors in a Genome-wide Meta-analysis.
  |RiskAllele=
  |Pval=4E-7
  |OR=1.11
  |ORtxt=[1.06-1.15]
  |OA=1
}}

{{PMID Auto
|PMID=24256810
|Title=Identification and Characterization of Functional Risk Variants for Colorectal Cancer Mapping to Chromosome 11q23.1
}}

{{PMID Auto
|PMID=22848671
|Title=Association of eleven common, low-penetrance colorectal cancer susceptibility genetic variants at six risk loci with clinical outcome.
|OA=1
}}

{{PMID Auto
|PMID=22987364
|Title=Combined analysis of three Lynch syndrome cohorts confirms the modifying effects of 8q23.3 and 11q23.1 in MLH1 mutation carriers.
}}

{{PMID Auto
|PMID=22999960
|Title=Much of the genetic risk of colorectal cancer is likely to be mediated through susceptibility to adenomas.
|OA=1
}}

{{PMID Auto
|PMID=23434150
|Title=Are the common genetic variants associated with colorectal cancer risk for DNA mismatch repair gene mutation carriers?
|OA=1
}}

{{PMID Auto
|PMID=24801760
|Title=Common colorectal cancer risk alleles contribute to the multiple colorectal adenoma phenotype, but do not influence colonic polyposis in FAP
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}