{{Rsnum
|rsid=3803300
|Gene=ZBTB42
|Chromosome=14
|position=104803442
|Orientation=minus
|GMAF=0.2902
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
|Gene_s=ZBTB42
}}{{PMID|17915974}} G allele associated with [[schizophrenia]]

{{PMID|18855532}} among 120 (likely Japanese) first-episode neuroleptic-naive schizophrenics treated with [[risperidone]] genotyped for 30 variants in misc. dopamine and serotonin (receptors and otherwise) two SNPs in DRD2 ([[rs1799989]] and [[rs1800497]]) and two SNPs in AKT1 ([[rs3803300]] and [[rs2494732]]) were significant predictors of treatment response to risperidone

The ancestral allele is G in the [http://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?rs=rs3803300 dbSNP] database.

{{PharmGKB
|RSID=rs3803300
|Name_s=
|Gene_s=AKT1
|Feature=
|Evidence=PubMed ID:18855532
|Annotation=This SNP is significant predictor of treatment response to risperidone in first-episode schizophrenia.
|Drugs=risperidone
|Drug Classes=
|Diseases=Schizophrenia
|Curation Level=Curated
|PharmGKB Accession ID=PA162356248
}}

{{PMID Auto
|PMID=22277669
|Title=Genetic overlap between schizophrenia and bipolar disorder: A study with AKT1 gene variants and clinical phenotypes
}}

{{PMID Auto
|PMID=16260726
|Title=Detection of functional single-nucleotide polymorphisms that affect apoptosis.
|OA=1
}}

{{PMID Auto
|PMID=16395129
|Title=Absence of significant associations between four AKT1 SNP markers and schizophrenia in the Taiwanese population.
}}

{{PMID Auto
|PMID=17464696
|Title=AKT1 and neurocognition in schizophrenia.
}}

{{PMID Auto
|PMID=18715757
|Title=Genetic associations with schizophrenia: meta-analyses of 12 candidate genes.
|OA=1
}}

{{PMID Auto
|PMID=19911060
|Title=Persistence criteria for susceptibility genes for schizophrenia: a discussion from an evolutionary viewpoint.
|OA=1
}}

{{PMID Auto
|PMID=19931325
|Title=No association between AKT1 polymorphism and schizophrenia: a case-control study in a Korean population and a meta-analysis.
}}

{{PMID Auto
|PMID=20046382
|Title=AKT1 Gene Polymorphisms and Obstetric Complications in the Patients with Schizophrenia.
|OA=1
}}

{{PMID Auto
|PMID=21842521
|Title=AKT1 polymorphisms and survival of early stage non-small cell lung cancer.
}}

{{GET Evidence
|impact=pharmacogenetic
|qualified_impact=Insufficiently evaluated pharmacogenetic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs3803300
|overall_frequency_n=94
|overall_frequency_d=128
|overall_frequency=0.734375
|n_genomes=49
|n_genomes_annotated=0
|n_haplomes=78
|n_articles=1
|n_articles_annotated=0
|in_pharmgkb=Y
|autoscore=1
|webscore=N
}}

{{PMID Auto
|PMID=25060489
|Title=Genetic variants in AKT1 gene were associated with risk and survival of OSCC in Chinese Han Population
}}
{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | HumanOmni1Quad}}