{{Rsnum
|rsid=3803304
|Gene=AKT1
|Chromosome=14
|position=104772809
|Orientation=minus
|GMAF=0.2057
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;G)
|geno3=(G;G)
|effect1=
|effect2=
|effect3=
|Gene_s=AKT1
}}{{ population diversity
| geno1=(C;C)
| geno2=(C;G)
| geno3=(G;G)
| CEU | 9.2 | 27.7 | 63.1
| HCB | 2.2 | 8.9 | 88.9
| JPT | 2.3 | 38.6 | 59.1
| YRI | 0.0 | 0.0 | 0.0
| ASW | 0.0 | 0.0 | 0.0
| CHB | 2.2 | 8.9 | 88.9
| CHD | 0.0 | 0.0 | 0.0
| GIH | 0.0 | 0.0 | 0.0
| LWK | 0.0 | 0.0 | 0.0
| MEX | 0.0 | 0.0 | 0.0
| MKK | 0.0 | 0.0 | 0.0
| TSI | 0.0 | 0.0 | 0.0
| HapMapRevision=28
}}[[rs3803304]] is an intronic SNP in the [[AKT1]] gene.

[[rs3803304]] was significantly associated with [[longevity]] in a meta-analysis across three cohorts (odds ratio 0.78, CI: 0.68-0.89, adjusted p=0.043).{{PMID|19489743|OA=1
}}

{{PMID Auto
|PMID=19164214
|Title=Genetic variations in the PI3K/PTEN/AKT/mTOR pathway are associated with clinical outcomes in esophageal cancer patients treated with chemoradiotherapy
|OA=1
}}

{{PMID Auto
|PMID=20132317
|Title=Association between AKT1 but not AKTIP genetic variants and increased risk for suicidal behavior in bipolar patients
}}
{{PMID Auto
|PMID=20447721
|Title=PI3K/PTEN/AKT/mTOR pathway genetic variation predicts toxicity and distant progression in lung cancer patients receiving platinum-based chemotherapy
|OA=1
}}

{{PMID Auto
|PMID=24421178
|Title=PI3K/PTEN/AKT/mTOR pathway genetic variations are associated with the clinical outcome in patients with squamous cell carcinoma of the head and neck receiving cetuximab-docetaxel treatment
}}

{{PMID Auto
|PMID=22113349
|Title=Gene set analysis of GWAS data for human longevity highlights the relevance of the insulin/IGF-1 signaling and telomere maintenance pathways.
|OA=1
}}

{{PMID Auto
|PMID=22929028
|Title=AKT1 fails to replicate as a longevity-associated gene in Danish and German nonagenarians and centenarians.
|OA=1
}}

{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}