{{Rsnum
|rsid=3811647
|Gene=TF
|Chromosome=3
|position=133765185
|Orientation=plus
|GMAF=0.3393
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
|Gene_s=TF
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;G)
| geno3=(G;G)
| CEU | 14.2 | 43.4 | 42.5
| HCB | 14.0 | 45.6 | 40.4
| JPT | 21.2 | 46.0 | 32.7
| YRI | 4.8 | 25.2 | 70.1
| ASW | 8.8 | 35.1 | 56.1
| CHB | 14.0 | 45.6 | 40.4
| CHD | 18.5 | 49.1 | 32.4
| GIH | 22.8 | 53.5 | 23.8
| LWK | 1.8 | 37.6 | 60.6
| MEX | 10.5 | 56.1 | 33.3
| MKK | 5.1 | 36.5 | 58.3
| TSI | 12.7 | 46.1 | 41.2
| HapMapRevision=28
}}
{{PMID Auto GWAS
|PMID=19084217
|Trait=Serum markers of iron status
|Title=Variants in TF and HFE explain approximately 40% of genetic variation in serum-transferrin levels
|RiskAllele=
|Pval=3E-15
|OR=0.46
|ORtxt=[0.34-0.58] SD decrease
|OA=1
}}

{{omim
|desc=TRANSFERRIN; TF
|id=190000
|rsnum=3811647
}}

{{PharmGKB
|RSID=rs3811647
|Name_s=
|Gene_s=TF
|Feature=
|Evidence=PubMed ID:19084217
|Annotation=In a GWAS performed on 459 female monozygotic twin pairs, all Australians of European descent, this SNP was found to be significantly associated with serum transferrin (p = 3.0 x 10 (-15)).
|Drugs=
|Drug Classes=
|Diseases=
|Curation Level=Curated
|PharmGKB Accession ID=PA164920573
}}

{{PharmGKB
|RSID=rs3811647
|Name_s=
|Gene_s=TF
|Feature=
|Evidence=PubMed ID:19084217; Web Resource:http://www.genome.gov/gwastudies/
|Annotation=GWAS results: Variants in TF and HFE explain approximately 40% of genetic variation in serum-transferrin levels. (Initial Sample Size: 459 twin pairs; Replication Sample Size: NR); (Region: 3q22.1; Reported Gene(s): TF; Risk Allele: rs3811647-?); (p-value= 0.000000000000003).This variant is associated with Serum markers of iron status.
|Drugs=
|Drug Classes=
|Diseases=
|Curation Level=Non-Curated
|PharmGKB Accession ID=PA164740111
}}
{{PMID Auto
|PMID=21208937
|Title=Identification of a common variant in the TFR2 gene implicated in the physiological regulation of serum iron levels
|OA=1
}}

{{PMID Auto GWAS
|PMID=21665994
|Trait=None
|Title=Genome-wide association study identifies two loci strongly affecting transferrin glycosylation.
|RiskAllele=A
|Pval=1E-35
|OR=0.3580
|ORtxt=[0.30-0.42] unit increase
|OA=1
}}

{{PMID Auto GWAS
|PMID=21785125
|Trait=None
|Title=Association of HFE and TMPRSS6 genetic variants with iron and erythrocyte parameters is only in part dependent on serum hepcidin concentrations.
|RiskAllele=
|Pval=2E-16
|OR=0.3380
|ORtxt=[0.26-0.42] ng/ml increase
}}

{{PMID Auto
|PMID=19673882
|Title=A novel association between a SNP in CYBRD1 and serum ferritin levels in a cohort study of HFE hereditary haemochromatosis.
|OA=1
}}

{{PMID Auto
|PMID=22323359
|Title=TMPRSS6, but not TF, TFR2 or BMP2 variants are associated with increased risk of iron-deficiency anemia.
}}

{{GET Evidence
|impact=pathogenic
|qualified_impact=Insufficiently evaluated pathogenic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs3811647
|overall_frequency_n=37
|overall_frequency_d=128
|overall_frequency=0.289062
|n_genomes=25
|n_genomes_annotated=0
|n_haplomes=29
|n_articles=1
|n_articles_annotated=0
|in_gwas=Y
|in_pharmgkb=Y
|autoscore=2
|webscore=N
}}

{{PMID Auto
|PMID=23903878
|Title=Prenatal methylmercury exposure and genetic predisposition to cognitive deficit at age 8 years
}}

{{PMID Auto
|PMID=23092954
|Title=SHAVE: shrinkage estimator measured for multiple visits increases power in GWAS of quantitative traits.
|OA=1
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}