{{Rsnum
|rsid=3816587
|Gene=ANAPC4
|Chromosome=4
|position=25415622
|Orientation=plus
|GMAF=0.4683
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;T)
|geno3=(T;T)
|Gene_s=ANAPC4
}}{{ population diversity
| geno1=(C;C)
| geno2=(C;T)
| geno3=(T;T)
| CEU | 17.9 | 49.1 | 33.0
| HCB | 46.3 | 47.1 | 6.6
| JPT | 45.0 | 43.2 | 11.7
| YRI | 30.6 | 49.0 | 20.4
| ASW | 38.6 | 38.6 | 22.8
| CHB | 46.3 | 47.1 | 6.6
| CHD | 50.5 | 39.4 | 10.1
| GIH | 34.0 | 51.0 | 15.0
| LWK | 36.7 | 51.4 | 11.9
| MEX | 17.5 | 52.6 | 29.8
| MKK | 27.7 | 49.7 | 22.6
| TSI | 27.5 | 46.1 | 26.5
| HapMapRevision=28
}}
[[rs3816587]] has been reported in a large study to be associated with [[rheumatoid arthritis]].

The risk allele (oriented to the dbSNP entry) is (C); the odds ratio associated with heterozygotes is 0.91 (CI 0.80-1.04), and for homozygotes, 1.35 (CI 1.14-1.59). {{PMID|17554300|OA=1
}}

{{GWAS Summary
|SNP=rs3816587
|PubMedID=17554300
|Condition=Rheumatoid arthritis
|Gene=NR
|Risk Allele=C
|pValue=9.00E-006
|OR=1.09
|95CI=0.96-1.25
|OA=1
}}

{{PharmGKB
|RSID=rs3816587
|Name_s=
|Gene_s=ANAPC4
|Feature=
|Evidence=PubMed ID:17554300; Web Resource:http://www.genome.gov/gwastudies/
|Annotation=GWAS Results: Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls (Initial Sample Size: 1,860 cases, 2,938 controls; Replication Sample Size: NR; Risk Allele: rs3816587-C). This variant is associated with rheumatoid arthritis.
|Drugs=
|Drug Classes=
|Diseases=Arthritis, Rheumatoid
|Curation Level=Non-Curated
|PharmGKB Accession ID=PA162356653
}}

{{PMID Auto
|PMID=18794857
|Title=Rheumatoid arthritis susceptibility loci at chromosomes 10p15, 12q13 and 22q13.
|OA=1
}}

{{PMID Auto
|PMID=20017963
|Title=Representation of genetic association via attributable familial relative risks in order to identify polymorphisms functionally relevant to rheumatoid arthritis.
|OA=1
}}

{{GET Evidence
|impact=pathogenic
|qualified_impact=Insufficiently evaluated pathogenic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs3816587
|overall_frequency_n=67
|overall_frequency_d=128
|overall_frequency=0.523438
|n_genomes=40
|n_genomes_annotated=0
|n_haplomes=58
|n_articles=0
|n_articles_annotated=0
|in_gwas=Y
|in_pharmgkb=Y
|autoscore=2
|webscore=N
}}

{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Affy GenomeWide 6}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}