{{Rsnum
|rsid=3817198
|Gene=LSP1
|Chromosome=11
|position=1887776
|Orientation=plus
|GMAF=0.2084
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;T)
|geno3=(T;T)
|Gene_s=LOC102724536,LSP1
}}{{ population diversity
| geno1=(C;C)
| geno2=(C;T)
| geno3=(T;T)
| CEU | 9.7 | 46.0 | 44.2
| HCB | 2.2 | 17.5 | 80.3
| JPT | 0.0 | 23.0 | 77.0
| YRI | 0.0 | 18.4 | 81.6
| ASW | 0.0 | 14.0 | 86.0
| CHB | 2.2 | 17.5 | 80.3
| CHD | 2.8 | 18.3 | 78.9
| GIH | 14.9 | 42.6 | 42.6
| LWK | 3.6 | 37.3 | 59.1
| MEX | 6.9 | 31.0 | 62.1
| MKK | 2.6 | 28.8 | 68.6
| TSI | 8.8 | 50.0 | 41.2
| HapMapRevision=28
}}
{{GWAS Summary
|SNP=rs3817198
|PubMedID=17529967
|Condition=Breast cancer
|Gene=LSP1
|Risk Allele=T
|pValue=3.00E-009
|OR=1.07
|95CI=1.04-1.11
|OA=1
}}
{{PharmGKB
|RSID=rs3817198
|Name_s=
|Gene_s=LSP1
|Feature=
|Evidence=PubMed ID:17529967; Web Resource:http://www.genome.gov/gwastudies/
|Annotation=GWAS Results: Genome-wide association study identifies novel breast cancer susceptibility loci (Initial Sample Size: 390 cases, 364 controls; Replication Sample Size: 26,646 cases, 24,889 controls; Risk Allele: rs3817198-T).
|Drugs=
|Drug Classes=
|Diseases=Breast Neoplasms
|Curation Level=Non-Curated
|PharmGKB Accession ID=PA162356624
}}
{{omim
|desc=LYMPHOCYTE-SPECIFIC PROTEIN;  LSP1
|id=153432
|rsnum=3817198
}}
{{omim
|desc=BREAST CANCER
|id=114480
|rsnum=3817198
}}
{{omim
|desc=BRCA2 GENE; BRCA2
|id=600185
|rsnum=3817198
}}
The common allele rs3817198(T) increases risk [[breast cancer]] by about +10%. For [[BRCA2]] mutation carriers the effect is reversed with rs3817198(C) associated with increased breast cancer risk {{PMID|19656774|OA=1
}} .

{{PMID|17529967|OA=1
}} [[rs3817198]], a SNP associated with the [[LSP1]] gene, was one of the four strongest associating SNPs found in a genome-wide association study of over 4,000 [[breast cancer]] samples. 
{{PMID Auto
|PMID=19656774
|Title=Common variants in LSP1, 2q35 and 8q24 and breast cancer risk for BRCA1 and BRCA2 mutation carriers
|OA=1
}}

{{PMID Auto
|PMID=20145138
|Title=Common genetic variants associated with breast cancer and mammographic density measures that predict disease
}}
{{PMID Auto
|PMID=20054709
|Title=Birth weight, breast cancer susceptibility loci, and breast cancer risk
}}
{{PMID Auto
|PMID=20699374
|Title=Evaluation of Breast Cancer Susceptibility Loci in Chinese Women
|OA=1
}}

{{PMID Auto
|PMID=21127985
|Title=Association of a LSP1 gene rs3817198T&gt;C polymorphism with breast cancer risk: evidence from 33,920 cases and 35,671 controls
}}
{{PMID Auto
|PMID=21197568
|Title=Risk of genome-wide association study newly identified genetic variants for breast cancer in Chinese women of Heilongjiang Province
}}

{{PMID Auto
|PMID=21445572
|Title=Genetic polymorphisms and breast cancer risk: evidence from meta-analyses, pooled analyses, and genome-wide association studies
}}

{{PMID Auto
|PMID=21791674
|Title=Interactions Between Genetic Variants and Breast Cancer Risk Factors in the Breast and Prostate Cancer Cohort Consortium
|OA=1
}}

{{PMID Auto
|PMID=22357627
|Title=Evaluation of 19 Susceptibility Loci of Breast Cancer in Women of African Ancestry
|OA=1
}}

{{PMID Auto
|PMID=17997823
|Title=Clinical correlates of low-risk variants in FGFR2, TNRC9, MAP3K1, LSP1 and 8q24 in a Dutch cohort of incident breast cancer cases.
|OA=1
}}

{{PMID Auto
|PMID=18224312
|Title=Pharmacogenetics: data, concepts and tools to improve drug discovery and drug treatment.
|OA=1
}}

{{PMID Auto
|PMID=18326623
|Title=Genome-wide association study provides evidence for a breast cancer risk locus at 6q22.33.
|OA=1
}}

{{PMID Auto
|PMID=18437204
|Title=Heterogeneity of breast cancer associations with five susceptibility loci by clinical and pathological characteristics.
|OA=1
}}

{{PMID Auto
|PMID=18612136
|Title=Discriminatory accuracy from single-nucleotide polymorphisms in models to predict breast cancer risk.
|OA=1
}}

{{PMID Auto
|PMID=18681954
|Title=Breast cancer susceptibility loci and mammographic density.
|OA=1
}}

{{PMID Auto
|PMID=18708391
|Title=Breast cancer risk polymorphisms and interaction with ionizing radiation among U.S. radiologic technologists.
|OA=1
}}

{{PMID Auto
|PMID=18772892
|Title=Can genes for mammographic density inform cancer aetiology?
|OA=1
}}

{{PMID Auto
|PMID=18785201
|Title=Novel breast cancer risk alleles and endometrial cancer risk.
|OA=1
}}

{{PMID Auto
|PMID=18973230
|Title=Breast cancer susceptibility alleles and ovarian cancer risk in 2 study populations.
|OA=1
}}

{{PMID Auto
|PMID=19088016
|Title=Genetic susceptibility loci for breast cancer by estrogen receptor status.
|OA=1
}}

{{PMID Auto
|PMID=19219042
|Title=Genome-wide association study identifies a new breast cancer susceptibility locus at 6q25.1.
|OA=1
}}

{{PMID Auto
|PMID=19232126
|Title=Association between breast cancer susceptibility loci and mammographic density: the Multiethnic Cohort.
|OA=1
}}

{{PMID Auto
|PMID=19304784
|Title=Association between invasive ovarian cancer susceptibility and 11 best candidate SNPs from breast cancer genome-wide association study.
|OA=1
}}

{{PMID Auto
|PMID=19330030
|Title=A multistage genome-wide association study in breast cancer identifies two new risk alleles at 1p11.2 and 14q24.1 (RAD51L1).
|OA=1
}}

{{PMID Auto
|PMID=19543528
|Title=Association between common germline genetic variation in 94 candidate genes or regions and risks of invasive epithelial ovarian cancer.
|OA=1
}}

{{PMID Auto
|PMID=19567422
|Title=Risk of estrogen receptor-positive and -negative breast cancer and single-nucleotide polymorphism 2q35-rs13387042.
|OA=1
}}

{{PMID Auto
|PMID=19639606
|Title=Correcting "winner's curse" in odds ratios from genomewide association findings for major complex human diseases.
|OA=1
}}

{{PMID Auto
|PMID=19931039
|Title=Using lifetime risk estimates in personal genomic profiles: estimation of uncertainty.
|OA=1
}}

{{PMID Auto
|PMID=20085711
|Title=Leveraging genetic variability across populations for the identification of causal variants.
|OA=1
}}

{{PMID Auto
|PMID=20146796
|Title=Familial relative risks for breast cancer by pathological subtype: a population-based cohort study.
|OA=1
}}

{{PMID Auto
|PMID=20237344
|Title=Performance of common genetic variants in breast-cancer risk models.
|OA=1
}}

{{PMID Auto
|PMID=20484103
|Title=Genetic and clinical predictors for breast cancer risk assessment and stratification among Chinese women.
|OA=1
}}

{{PMID Auto
|PMID=20605201
|Title=Gene-environment interactions in 7610 women with breast cancer: prospective evidence from the Million Women Study.
|OA=1
}}

{{PMID Auto
|PMID=21596841
|Title=Low penetrance breast cancer susceptibility loci are associated with specific breast tumor subtypes: findings from the Breast Cancer Association Consortium.
|OA=1
}}

{{PMID Auto
|PMID=22045194
|Title=Combined effect of low-penetrant SNPs on breast cancer risk.
|OA=1
}}

{{PMID Auto
|PMID=22454379
|Title=Common Breast Cancer Susceptibility Variants in LSP1 and RAD51L1 Are Associated with Mammographic Density Measures that Predict Breast Cancer Risk.
|OA=1
}}

{{PMID Auto
|PMID=22532573
|Title=The role of genetic breast cancer susceptibility variants as prognostic factors.
|OA=1
}}

{{GET Evidence
|impact=pathogenic
|qualified_impact=Insufficiently evaluated pathogenic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs3817198
|overall_frequency_n=24
|overall_frequency_d=128
|overall_frequency=0.1875
|n_genomes=19
|n_genomes_annotated=0
|n_haplomes=23
|n_articles=0
|n_articles_annotated=0
|in_gwas=Y
|in_pharmgkb=Y
|autoscore=2
|webscore=N
}}

{{PMID Auto
|PMID=23756864
|Title=Estimating single nucleotide polymorphism associations using pedigree data: applications to breast cancer
}}

{{PMID Auto GWAS
  |PMID=23535729
  |Trait=Breast cancer
  |Title=Large-scale genotyping identifies 41 new loci associated with breast cancer risk.
  |RiskAllele=C
  |Pval=2E-11
  |OR=1.07
  |ORtxt=[1.05-1.09]
  |OA=1
}}

{{PMID Auto
|PMID=22910930
|Title=Genome-Wide Association Studies (GWAS) breast cancer susceptibility loci in Arabs: susceptibility and prognostic implications in Tunisians.
|OA=1
}}

{{PMID Auto
|PMID=23577780
|Title=Associations between single-nucleotide polymorphisms and epidural ropivacaine consumption in patients undergoing breast cancer surgery.
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Affy GenomeWide 6}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}