{{Rsnum
|rsid=3818361
|Gene=CR1
|Chromosome=1
|position=207611623
|Orientation=minus
|GMAF=0.2691
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;T)
|geno3=(T;T)
|Gene_s=CR1
}}{{ population diversity
| geno1=(C;C)
| geno2=(C;T)
| geno3=(T;T)
| CEU | 58.4 | 31.9 | 9.7
| HCB | 42.3 | 45.3 | 12.4
| JPT | 49.6 | 38.1 | 12.4
| YRI | 29.9 | 47.6 | 22.4
| ASW | 28.1 | 54.4 | 17.5
| CHB | 42.3 | 45.3 | 12.4
| CHD | 44.4 | 41.7 | 13.9
| GIH | 89.1 | 9.9 | 1.0
| LWK | 31.8 | 61.8 | 6.4
| MEX | 75.9 | 24.1 | 0.0
| MKK | 37.2 | 48.1 | 14.7
| TSI | 62.7 | 33.3 | 3.9
| HapMapRevision=28
}}

[[rs3818361]] is a SNP associated with the complement component (3b/4b) receptor 1 [[CR1]] gene.

{{PMID|20554627|OA=1
}} The association of this SNP and late-onset [[Alzheimer's disease]] was replicated over a total of another 1829 cases (and 2576 controls). The odds ratio for [[rs3818361]](T) allele was 1.15 (note the p value was 0.014).

{{PMID Auto
|PMID=20558149
|Title=Complement receptor 1 polymorphisms and risk of late onset Alzheimer's disease
}}
{{PMID Auto
|PMID=20697030
|Title=Meta-analysis Confirms CR1, CLU, and PICALM as Alzheimer Disease Risk Loci and Reveals Interactions With APOE Genotypes
|OA=1
}}

{{PMID Auto
|PMID=21321396
|Title=Replication of BIN1 Association with Alzheimer's Disease and Evaluation of Genetic Interactions
|OA=1
}}

{{PMID Auto GWAS
|PMID=21460840
|Trait=None
|Title=Common variants at ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease
|RiskAllele=
|Pval=4E-14
|OR=1.1800
|ORtxt=[1.13-1.24]
|OA=1
}}

{{PMID Auto
|PMID=19734902
|Title=Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease.
|OA=1
}}

{{PMID Auto
|PMID=21379329
|Title=Genome-wide association of familial late-onset Alzheimer's disease replicates BIN1 and CLU and nominates CUGBP2 in interaction with APOE.
|OA=1
}}

{{PMID Auto
|PMID=21390209
|Title=Meta-analysis for genome-wide association study identifies multiple variants at the BIN1 locus associated with late-onset Alzheimer's disease.
|OA=1
}}

{{PMID Auto
|PMID=22244847
|Title=Alzheimer's disease risk factor complement receptor 1 is associated with depression.
}}

{{PMID Auto
|PMID=22402018
|Title=Implication of common and disease specific variants in CLU, CR1, and PICALM
}}

{{PMID Auto
|PMID=23419238
|Title=Allele-specific polymerase chain reaction for the detection of Alzheimer's disease-related single nucleotide polymorphisms
|OA=1
}}

{{PMID Auto
|PMID=22430674
|Title=Genome-wide haplotype association study identifies the FRMD4A gene as a risk locus for Alzheimer's disease.
|OA=1
}}

{{PMID Auto
|PMID=23022416
|Title=Effect of complement CR1 on brain amyloid burden during aging and its modification by APOE genotype.
|OA=1
}}

{{PMID Auto
|PMID=24998857
|Title=CR1 is potentially associated with rate of decline in sporadic Alzheimer's disease
}}
{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | FTDNA2}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}