{{Rsnum
|rsid=3821236
|Gene=STAT4
|Chromosome=2
|position=191038032
|Orientation=plus
|GMAF=0.309
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|Summary=risk of Systemic lupus erythematosus
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
|Gene_s=STAT4
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;G)
| geno3=(G;G)
| CEU | 5.3 | 32.7 | 61.9
| HCB | 19.7 | 51.8 | 28.5
| JPT | 19.5 | 43.4 | 37.2
| YRI | 10.2 | 40.8 | 49.0
| ASW | 10.5 | 40.4 | 49.1
| CHB | 19.7 | 51.8 | 28.5
| CHD | 17.4 | 54.1 | 28.4
| GIH | 4.0 | 34.7 | 61.4
| LWK | 8.2 | 48.2 | 43.6
| MEX | 25.9 | 51.7 | 22.4
| MKK | 4.5 | 38.5 | 57.1
| TSI | 2.0 | 33.3 | 64.7
| HapMapRevision=28
}}
{{CPMC SNP
|link=http://cpmc.coriell.org/Sections/Genes/Lupus.aspx?PgId=198
}}{{PMID Auto GWAS
|PMID=18677312
|Trait=Systemic lupus erythematosus
|Title=Genetic variants near TNFAIP3 on 6q23 are associated  with systemic lupus erythematosus
|RiskAllele=
|Pval=7.9999999999999995E-11
|OR=1.49
|ORtxt=[NR]
}}
[[CPMC]] uses this to indicate increased risk of [[Systemic lupus erythematosus]].

{{PMID Auto
|PMID=19644876
|Title=Association of STAT4 and BLK, but not BANK1 or IRF5, with primary antiphospholipid syndrome
}}

{{PMID Auto GWAS
|PMID=19165918
|Trait=Systemic lupus erythematosus
|Title=PubMedID=18677312: cannot get document summary
|RiskAllele=
|Pval=7.9999999999999995E-11
|OR=1.49
|ORtxt=[NR]
|OA=1
}}
{{PMID Auto GWAS
|PMID=20383147
|Trait=Systemic sclerosis
|Title=Genome-wide association study of systemic sclerosis identifies CD247 as a new susceptibility locus
|RiskAllele=A
|Pval=3E-9
|OR=1.30
|ORtxt=[1.19-1.41]
|OA=1
}}

{{PMID Auto GWAS
|PMID=21779181
|Trait=None
|Title=Identification of novel genetic markers associated with clinical phenotypes of systemic sclerosis through a genome-wide association strategy.
|RiskAllele=
|Pval=9E-8
|OR=1.3100
|ORtxt=[1.19-1.48]
|OA=1
}}

{{PMID Auto
|PMID=22440820
|Title=IRF5 polymorphism predicts prognosis in patients with systemic sclerosis
|OA=1
}}

{{PMID Auto
|PMID=18516230
|Title=Specificity of the STAT4 genetic association for severe disease manifestations of systemic lupus erythematosus.
|OA=1
}}

{{PMID Auto
|PMID=18579578
|Title=A risk haplotype of STAT4 for systemic lupus erythematosus is over-expressed, correlates with anti-dsDNA and shows additive effects with two risk alleles of IRF5.
|OA=1
}}

{{PMID Auto
|PMID=19019891
|Title=STAT4 associates with systemic lupus erythematosus through two independent effects that correlate with gene expression and act additively with IRF5 to increase risk.
|OA=1
}}

{{PMID Auto
|PMID=19287509
|Title=Genome-wide association study of determinants of anti-cyclic citrullinated peptide antibody titer in adults with rheumatoid arthritis.
|OA=1
}}

{{PMID Auto
|PMID=19333953
|Title=High-density genotyping of STAT4 reveals multiple haplotypic associations with systemic lupus erythematosus in different racial groups.
|OA=1
}}

{{PMID Auto
|PMID=20652065
|Title=Interferon alpha in systemic lupus erythematosus.
|OA=1
}}

{{PMID Auto
|PMID=20722033
|Title=The susceptibility loci juvenile idiopathic arthritis shares with other autoimmune diseases extend to PTPN2, COG6, and ANGPT1.
|OA=1
}}

{{GET Evidence
|impact=pathogenic
|qualified_impact=Insufficiently evaluated pathogenic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs3821236
|overall_frequency_n=33
|overall_frequency_d=128
|overall_frequency=0.257812
|n_genomes=23
|n_genomes_annotated=0
|n_haplomes=29
|n_articles=0
|n_articles_annotated=0
|in_gwas=Y
|autoscore=1
|webscore=N
}}

{{PMID Auto
|PMID=23755762
|Title=STAT4 is a genetic risk factor for systemic sclerosis in a Chinese population
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Affy GenomeWide 6}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}