{{Rsnum
|rsid=3834129
|Gene=CASP8
|Chromosome=2
|position=201232809
|Orientation=minus
|GMAF=0.3962
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(-;-)
|geno2=(-;CTTACT)
|geno3=(CTTACT;CTTACT)
|Gene_s=CASP8
}}[[rs3834129]] is a SNP in the [[CASP8]] gene that is also known as the -652 6N ins/del promoter variant.

It has been linked to higher risk for multiple tumours including colorectal cancer (CRC) in Chinese populations; however, it showed no association with [[colorectal cancer]] risk in a study of 4,000 UK cases.{{PMID|18362937|OA=1
}}

{{PMID Auto
|PMID=19276244
|Title=A Six-Nucleotide Insertion-Deletion Polymorphism in the CASP8 Promoter Associated with Risk and Progression of Bladder Cancer
}}

{{omim
|id=601763
|desc=CASPASE 8, APOPTOSIS-RELATED CYSTEINE PROTEASE; CASP8
|rsnum=3834129
}}

This page demonstrates a bug in [[User:SNPediaBot]]. It incorrectly assigned the genotype, probably because it is multiple letters. This makes a good test case. {{bug}}

{{PMID Auto
|PMID=20564345
|Title=Caspase-8 polymorphisms and risk of gallbladder cancer in a Northern Indian population
}}
{{PMID Auto
|PMID=20652397
|Title=The CASP8 rs3834129 polymorphism and breast cancer risk in BRCA1 mutation carriers
}}

{{PMID Auto
|PMID=21283657
|Title=Gallbladder Cancer Predisposition: A Multigenic Approach to DNA-Repair, Apoptotic and Inflammatory Pathway Genes
|OA=1
}}

{{omim
|id=601763
|rsnum=3834129
|variant=0004
}}

{{PMID Auto
|PMID=21714991
|Title=Polymorphisms in the CASP8 gene and the risk of epithelial ovarian cancer
}}

{{PMID Auto
|PMID=21633787
|Title=Polymorphisms in the promoter region of the CASP8 gene are not associated with non-Hodgkin's lymphoma in Chinese patients
}}

{{PMID Auto
|PMID=22056502
|Title=Fine-mapping CASP8 risk variants in breast cancer
|OA=1
}}

{{PMID Auto
|PMID=22323360
|Title=Genotypic variants at 2q33 and risk of esophageal squamous cell carcinoma in China: A meta-analysis of genome-wide association studies
|OA=1
}}

{{PMID Auto
|PMID=22568453
|Title=Association of CASP3 polymorphism with hematologic toxicity in advanced NSCLC patients treated with platinum-based chemotherapy
}}

{{PMID Auto
|PMID=22345985
|Title=A six-nucleotide deletion polymorphism in the casp8 promoter is associated with reduced risk of esophageal and gastric cancers in Kashmir valley
|OA=1
}}

{{PMID Auto
|PMID=18563783
|Title=Genetic variants and haplotypes of the caspase-8 and caspase-10 genes contribute to susceptibility to cutaneous melanoma.
|OA=1
}}

{{PMID Auto
|PMID=19318553
|Title=A breast cancer risk haplotype in the caspase-8 gene.
|OA=1
}}

{{PMID Auto
|PMID=19531679
|Title=Polymorphisms and haplotypes in the caspase-3, caspase-7, and caspase-8 genes and risk for endometrial cancer: a population-based, case-control study in a Chinese population.
|OA=1
}}

{{PMID Auto
|PMID=19542541
|Title=Polymorphisms in cell death pathway genes are associated with altered sperm apoptosis and poor semen quality.
}}

{{PMID Auto
|PMID=19629679
|Title=Association of two CASP8 polymorphisms with breast cancer risk: a meta-analysis.
}}

{{PMID Auto
|PMID=22659694
|Title=Bi-directional PCR allele-specific amplification (bi-PASA) for detection of caspase-8 -652 6N ins/del promoter polymorphism (rs3834129) in breast cancer.
}}

{{PMID Auto
|PMID=23170140
|Title=CASP-8 -652 6N ins/del polymorphism and cancer risk: A literature-based systematic HuGE review and meta-analysis
|OA=1
}}

{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}