{{Rsnum
|rsid=3842787
|Gene=PTGS1
|Chromosome=9
|position=122371228
|Orientation=plus
|GMAF=0.06841
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;T)
|geno3=(T;T)
|Gene_s=PTGS1
}}[[rs3842787]], also known as 50C>T, is a SNP in the signal peptide region of the cyclooxygenase-1 [[PTGS1]] gene.

A study of 696 European patients undergoing elective diagnostic coronary angiographies (CAGs) because of suspected or proven stable coronary artery disease found that 23 experienced bleeding, perhaps the most common complication of this type of invasive coronary procedure. After controlling for various variables (especially gender), two co-inherited SNPs, [[rs10306114]] and [[rs3842787]], were found to be associated with higher risk for bleeding in otherwise low risk patients who (i) did undergo percutaneous coronary intervention and (ii) did not take [[clopidogrel]]. Having the less common haplotype ([[rs10306114]](G) and/or [[rs3842787]](T)) increases the bleeding risk upon CAG ~12 fold (p = 0.012).{{PMID|20691446}}

{{ population diversity
| geno1=(C;C)
| geno2=(C;T)
| geno3=(T;T)
| CEU | 84.1 | 15.9 | 0.0
| HCB | 0.0 | 0.0 | 0.0
| JPT | 0.0 | 0.0 | 0.0
| YRI | 67.8 | 30.8 | 1.4
| ASW | 62.5 | 33.9 | 3.6
| CHB | 0.0 | 0.0 | 0.0
| CHD | 0.0 | 0.0 | 0.0
| GIH | 97.0 | 3.0 | 0.0
| LWK | 71.6 | 26.6 | 1.8
| MEX | 91.4 | 8.6 | 0.0
| MKK | 71.8 | 26.9 | 1.3
| TSI | 96.1 | 3.9 | 0.0
| HapMapRevision=28
}}

{{PMID Auto
|PMID=19786296
|Title=Platelet glycoprotein GP VI 13254C allele is an independent risk factor of premature myocardial infarction
}}

{{PMID Auto
|PMID=20214591
|Title=Pharmacogenomics in aspirin intolerance
}}

{{PharmGKB
|RSID=rs3842787
|Name_s=PTGS1: P17L; (C>T)
|Gene_s=PTGS1
|Feature=
|Evidence=PubMed ID:17301694
|Annotation=Risk-associated allele: not specified. Phenotype: In vitro inhibition studies with indomethacin demonstrated that the P17L variant was significantly more sensitive to indomethacin-mediated inhibition of PTGS1 activity relative to wild-type. Study type: FA
|Drugs=indomethacin
|Drug Classes=
|Diseases=
|Curation Level=Curated
|PharmGKB Accession ID=PA165291839
}}

{{PharmGKB
|RSID=rs3842787
|Name_s=PTGS1: P17L; (C>T)
|Gene_s=PTGS1
|Feature=
|Evidence=PubMed ID:19350112
|Annotation=Risk-associated allele: not specified. Phenotype: Serum thromboxane (TXB2), urinary 11-dehydro-TXB(2) and arachidonic acid-induced aggregation were measured in the group (n=30) taking a four-week course of low-dose aspirin. None of the indices evaluated was significantly different (p>0.05) between carriers of the 50T allele (n=1 homozygous, n=4 heterozygous) and carriers of the 50C allele (n=25 homozygous) at any time point during aspirin treatment and after withdrawal. In conclusion, this study found no relationship between the 50T/-842G haplotype and PTGS1 sensitivity to aspirin.
|Drugs=aspirin
|Drug Classes=
|Diseases=
|Curation Level=Curated
|PharmGKB Accession ID=PA165291840
}}

{{PMID Auto
|PMID=17355643
|Title=Frequencies of single nucleotide polymorphisms in genes regulating inflammatory responses in a community-based population.
|OA=1
}}

{{PMID Auto
|PMID=17495879
|Title=Cyclooxygenase polymorphisms and risk of cardiovascular events: the Atherosclerosis Risk in Communities (ARIC) study.
|OA=1
}}

{{PMID Auto
|PMID=18992148
|Title=Low-penetrance alleles predisposing to sporadic colorectal cancers: a French case-controlled genetic association study.
|OA=1
}}

{{PMID Auto
|PMID=19046748
|Title=Variation in eicosanoid genes, non-fatal myocardial infarction and ischemic stroke.
|OA=1
}}

{{GET Evidence
|gene=PTGS1
|aa_change=Pro17Leu
|aa_change_short=P17L
|impact=pharmacogenetic
|qualified_impact=Insufficiently evaluated pharmacogenetic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs3842787
|overall_frequency_n=969
|overall_frequency_d=10756
|overall_frequency=0.0900893
|n_genomes=6
|n_genomes_annotated=0
|n_haplomes=6
|n_articles=2
|n_articles_annotated=2
|in_pharmgkb=Y
|nblosum100=7
|autoscore=1
|webscore=N
}}

{{PMID Auto
|PMID=23765972
|Title=Interaction between ALOX5AP-SG13S114A/T and COX-2-765G/C increases susceptibility to cerebral infarction in a Chinese population
}}

{{PMID Auto
|PMID=23029430
|Title=Prognostic role of host cyclooxygenase and cytokine genotypes in a Caucasian cohort of patients with gastric adenocarcinoma.
|OA=1
}}

{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | FTDNA2}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}