{{Rsnum
|rsid=3851179
|Chromosome=11
|position=86157598
|Orientation=minus
|GMAF=0.3297
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
}}
{{ population diversity
| geno1=(A;A)
| geno2=(A;G)
| geno3=(G;G)
| CEU | 17.7 | 46.9 | 35.4
| HCB | 19.1 | 51.5 | 29.4
| JPT | 16.8 | 46.0 | 37.2
| YRI | 0.0 | 13.6 | 86.4
| ASW | 0.0 | 25.0 | 75.0
| CHB | 19.1 | 51.5 | 29.4
| CHD | 13.9 | 52.8 | 33.3
| GIH | 16.0 | 45.0 | 39.0
| LWK | 2.7 | 21.8 | 75.5
| MEX | 25.9 | 36.2 | 37.9
| MKK | 1.3 | 22.4 | 76.3
| TSI | 16.7 | 41.2 | 42.2
| HapMapRevision=28
}}[[rs3851179]] is a SNP upstream of the [[PICALM]] gene.

A study of over 5,000 [[Alzheimer's disease]] patients (and over 10,000 controls) found a slight protective effect of the (A) allele of this SNP. [[rs3851179]](A) carriers had a slightly decreased risk for [[Alzheimer's disease]], with an odds ratio of 0.85 (CI: 0.8-0.9, p=1.9x10e-8).{{doi|10.1038/ng.440}}

{{PMID|20554627|OA=1
}} The association of this SNP and late-onset [[Alzheimer's disease]] was replicated over a total of another 1829 cases (and 2576 controls). 

{{PMID Auto GWAS
|PMID=19734902
|Trait=Alzheimer's disease
|Title=Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease
|RiskAllele=
|Pval=1E-9
|OR=1.16
|ORtxt=[1.11-1.22]
|OA=1
}}

{{PMID Auto
|PMID=20697030
|Title=Meta-analysis Confirms CR1, CLU, and PICALM as Alzheimer Disease Risk Loci and Reveals Interactions With APOE Genotypes
|OA=1
}}
{{PMID Auto
|PMID=20951388
|Title=Genetic association of PICALM polymorphisms with Alzheimer's disease in Han Chinese
}}

{{PMID Auto
|PMID=21321396
|Title=Replication of BIN1 Association with Alzheimer's Disease and Evaluation of Genetic Interactions
|OA=1
}}

{{PMID Auto
|PMID=21912625
|Title=An exploratory study on CLU, CR1 and PICALM and Parkinson disease
|OA=1
}}

{{PMID Auto
|PMID=22715855
|Title=Lack of association of the PICALM rs3851179 polymorphism with Parkinson's Disease in the Greek Population
}}

{{PMID Auto
|PMID=20451875
|Title=Alzheimer's Disease Neuroimaging Initiative biomarkers as quantitative phenotypes: Genetics core aims, progress, and plans.
|OA=1
}}

{{PMID Auto
|PMID=20738160
|Title=Association analysis between the rs11136000 single nucleotide polymorphism in clusterin gene, rs3851179 single nucleotide polymorphism in clathrin assembly lymphoid myeloid protein gene and the patients with schizophrenia in the Chinese population.
}}

{{PMID Auto
|PMID=20739100
|Title=Genetic variations in the CLU and PICALM genes are associated with cognitive function in the oldest old.
|OA=1
}}

{{PMID Auto
|PMID=21297266
|Title=Implication of a genetic variant at PICALM in Alzheimer's disease patients and centenarians.
}}

{{PMID Auto
|PMID=21347408
|Title=Fine mapping of genetic variants in BIN1, CLU, CR1 and PICALM for association with cerebrospinal fluid biomarkers for Alzheimer's disease.
|OA=1
}}

{{PMID Auto
|PMID=21358043
|Title=PICALM and CR1 variants are not associated with sporadic Alzheimer's disease in Chinese patients.
}}

{{PMID Auto
|PMID=21379329
|Title=Genome-wide association of familial late-onset Alzheimer's disease replicates BIN1 and CLU and nominates CUGBP2 in interaction with APOE.
|OA=1
}}

{{PMID Auto
|PMID=21390209
|Title=Meta-analysis for genome-wide association study identifies multiple variants at the BIN1 locus associated with late-onset Alzheimer's disease.
|OA=1
}}

{{PMID Auto
|PMID=21726919
|Title=CR1 genotype is associated with entorhinal cortex volume in young healthy adults.
}}

{{PMID Auto
|PMID=22015308
|Title=Polymorphisms of CR1, CLU and PICALM confer susceptibility of Alzheimer's disease in a southern Chinese population.
}}

{{PMID Auto
|PMID=23036585
|Title=Exploratory analysis of seven Alzheimer's disease genes: disease progression
}}

{{PMID Auto
|PMID=23040034
|Title=Lack of association between PICALM rs3851179 polymorphism and Alzheimer's disease in Chinese population and APOEε4-negative subgroup
}}

{{GET Evidence
|impact=pathogenic
|qualified_impact=Insufficiently evaluated pathogenic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs3851179
|overall_frequency_n=95
|overall_frequency_d=128
|overall_frequency=0.742188
|n_genomes=49
|n_genomes_annotated=0
|n_haplomes=78
|n_articles=0
|n_articles_annotated=0
|in_gwas=Y
|autoscore=1
|webscore=N
}}

{{PMID Auto
|PMID=22402018
|Title=Implication of common and disease specific variants in CLU, CR1, and PICALM
}}

{{PMID Auto
|PMID=23419238
|Title=Allele-specific polymerase chain reaction for the detection of Alzheimer's disease-related single nucleotide polymorphisms
|OA=1
}}

{{PMID Auto
|PMID=22943764
|Title=Identification and confirmation of an exonic splicing enhancer variation in exon 5 of the Alzheimer disease associated PICALM gene
|OA=1
}}

{{PMID Auto
|PMID=23572399
|Title=PICALM Gene rs3851179 Polymorphism Contributes to Alzheimer's Disease in an Asian Population
}}

{{PMID Auto
|PMID=23650005
|Title=Lack of association of CR1, PICALM and CLU gene polymorphisms with Alzheimer disease in a Polish population
}}

{{PMID Auto
|PMID=24618820
|Title=Genetics of PICALM Expression and Alzheimer's Disease
|OA=1
}}

{{PMID Auto
|PMID=22005930
|Title=Genome-wide association study of Alzheimer's disease with psychotic symptoms.
|OA=1
}}

{{PMID Auto
|PMID=23180304
|Title=Genetic risk score predicting accelerated progression from mild cognitive impairment to Alzheimer's disease.
}}

{{PMID Auto
|PMID=24788522
|Title=Genetic variation at the CELF1 (CUGBP, elav-like family member 1 gene) locus is genome-wide associated with Alzheimer's disease and obesity
}}

{{PMID Auto
|PMID=25169757
|Title=An intronic PICALM polymorphism, rs588076, is associated with allelic expression of a PICALM isoform
}}

{{PMID Auto
|PMID=20558387
|Title=Genetic variation and neuroimaging measures in Alzheimer disease.
}}

{{PMID Auto
|PMID=25189118
|Title=Late-onset Alzheimer's risk variants in memory decline, incident mild cognitive impairment, and Alzheimer's disease
}}
{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Affy GenomeWide 6}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}