{{Rsnum
|rsid=3857224
|Gene=ADH6
|Chromosome=4
|position=99208528
|Orientation=plus
|GMAF=0.4371
|Gene_s=ADH6
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;T)
|geno3=(T;T)
}}{{ population diversity
| geno1=(C;C)
| geno2=(C;T)
| geno3=(T;T)
| CEU | 44.2 | 46.9 | 8.8
| HCB | 0.0 | 16.1 | 83.9
| JPT | 0.0 | 18.6 | 81.4
| YRI | 12.9 | 48.3 | 38.8
| ASW | 19.3 | 42.1 | 38.6
| CHB | 0.0 | 16.1 | 83.9
| CHD | 0.9 | 23.9 | 75.2
| GIH | 23.8 | 53.5 | 22.8
| LWK | 16.4 | 49.1 | 34.5
| MEX | 25.9 | 43.1 | 31.0
| MKK | 28.2 | 48.1 | 23.7
| TSI | 48.0 | 40.2 | 11.8
| HapMapRevision=28
}}{{PMID Auto
|PMID=22690706
|Title=Association of alcohol dehydrogenase polymorphisms and lifestyle factors with excessive alcohol intake within the Spanish population (EPIC-Spain)
}}
<br>
A study of 653 Spanish heavy drinkers compared to 880 controls found [[ADH6]] gene [[rs3857224]](T) was associated with heavy alcohol intake in women (odds ratio 1.61, CI: 1.21–2.14, p = 10e−3), but not in men.

{{PMID Auto
|PMID=18331377
|Title=Association of ADH and ALDH genes with alcohol dependence in the Irish Affected Sib Pair Study of alcohol dependence (IASPSAD) sample.
|OA=1
}}

{{PMID Auto
|PMID=19193628
|Title=ADH single nucleotide polymorphism associations with alcohol metabolism in vivo.
|OA=1
}}

{{PMID Auto
|PMID=19247474
|Title=Genome-wide and candidate gene association study of cigarette smoking behaviors.
|OA=1
}}

{{PMID Auto
|PMID=19298322
|Title=Associations and interactions between SNPs in the alcohol metabolizing genes and alcoholism phenotypes in European Americans.
|OA=1
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | FTDNA2}}
{{on chip | FTDNA}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}