{{Rsnum
|rsid=3865418
|Gene=NEDD4L
|Chromosome=18
|position=58336932
|Orientation=plus
|GMAF=0.4747
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;T)
|geno3=(T;T)
|Gene_s=NEDD4L
}}{{ population diversity
| geno1=(C;C)
| geno2=(C;T)
| geno3=(T;T)
| CEU | 29.5 | 42.0 | 28.6
| HCB | 38.7 | 49.6 | 11.7
| JPT | 50.4 | 42.5 | 7.1
| YRI | 14.4 | 43.8 | 41.8
| ASW | 24.6 | 45.6 | 29.8
| CHB | 38.7 | 49.6 | 11.7
| CHD | 45.9 | 44.0 | 10.1
| GIH | 31.7 | 41.6 | 26.7
| LWK | 12.7 | 41.8 | 45.5
| MEX | 27.6 | 56.9 | 15.5
| MKK | 12.2 | 45.5 | 42.3
| TSI | 18.6 | 42.2 | 39.2
| HapMapRevision=28
}}[[rs3865418]], a SNP in the [[NEDD4L]] gene, has been associated with [[hypertension]] in a study of Chinese (Hans) patients.

Association under an additive model yielded an odds ratio of 1.31 (CI: 1.04-1.67, p=0.025) for the [[rs3865418]](T) allele. The association remained significant (p = 0.039) after adjusting for age and sex, and was primarily associated with significantly higher diastolic blood pressure.{{PMID|18293164}}

{{PMID Auto
|PMID=20003179
|Title=Genetic variation of NEDD4L is associated with essential hypertension in female Kazakh general population: a case-control study.
|OA=1
}}

{{PMID Auto
|PMID=23549273
|Title=A Functional Variant of NEDD4L Is Associated with Obesity and Related Phenotypes in a Han Population of Southern China.
|OA=1
}}

{{on chip | Affy GenomeWide 6}}