{{Rsnum
|rsid=3890745
|Gene=MMEL1
|Chromosome=1
|position=2622185
|Orientation=minus
|GMAF=0.4307
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
|Gene_s=MMEL1
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;G)
| geno3=(G;G)
| CEU | 46.0 | 41.6 | 12.4
| HCB | 19.0 | 58.4 | 22.6
| JPT | 25.7 | 52.2 | 22.1
| YRI | 17.7 | 47.6 | 34.7
| ASW | 21.1 | 47.4 | 31.6
| CHB | 19.0 | 58.4 | 22.6
| CHD | 18.3 | 54.1 | 27.5
| GIH | 31.7 | 52.5 | 15.8
| LWK | 19.1 | 36.4 | 44.5
| MEX | 37.9 | 46.6 | 15.5
| MKK | 17.3 | 50.0 | 32.7
| TSI | 53.9 | 41.2 | 4.9
| HapMapRevision=28
}}
{{GWAS Summary
|SNP=rs3890745
|PubMedID=18794853
|Condition=Rheumatoid arthritis
|Gene=MMEL1-TNFRSF14
|Risk Allele=T
|pValue=1.00E-007
|OR=1.12
|95CI=
|OA=1
}}

{{omim
|desc=RHEUMATOID ARTHRITIS; RA
|id=180300
|rsnum=3890745
}}

{{PharmGKB
|RSID=rs3890745
|Name_s=
|Gene_s=MMEL1
|Feature=
|Evidence=PubMed ID:18794853; Web Resource:http://www.genome.gov/gwastudies/
|Annotation=GWAS Results: Common variants at CD40 and other loci confer risk of rheumatoid arthritis (Initial Sample Size: 3,393 cases, 12,460 controls; Replication Sample Size: 3,929 cases, 5,807 controls; Risk Allele: rs3890745-T). This variant is associated with Rheumatoid arthritis.
|Drugs=
|Drug Classes=
|Diseases=Arthritis, Rheumatoid
|Curation Level=Non-Curated
|PharmGKB Accession ID=PA162356418
}}

{{PMID Auto GWAS
|PMID=20453842
|Trait=Rheumatoid arthritis
|Title=Genome-wide association study meta-analysis identifies seven new rheumatoid arthritis risk lock
|RiskAllele=T
|Pval=0.000004
|OR=1.12
|ORtxt=[1.06-1.18]
}}

{{PMID Auto
|PMID=21784728
|Title=Association of variants in MMEL1 and CTLA4 with rheumatoid arthritis in the Han Chinese population
}}

{{PMID Auto
|PMID=22365150
|Title=Use of a multiethnic approach to identify rheumatoid- arthritis-susceptibility loci, 1p36 and 17q12
|OA=1
}}

{{PMID Auto
|PMID=20007504
|Title=Comprehensive follow-up of the first genome-wide association study of multiple sclerosis identifies KIF21B and TMEM39A as susceptibility loci.
|OA=1
}}

{{PMID Auto
|PMID=20426808
|Title=AntEpiSeeker: detecting epistatic interactions for case-control studies using a two-stage ant colony optimization algorithm.
|OA=1
}}

{{PMID Auto
|PMID=20639879
|Title=Variants at IRF5-TNPO3, 17q12-21 and MMEL1 are associated with primary biliary cirrhosis.
|OA=1
}}

{{PMID Auto
|PMID=21383967
|Title=Meta-analysis of genome-wide association studies in celiac disease and rheumatoid arthritis identifies fourteen non-HLA shared loci.
|OA=1
}}

{{PMID Auto
|PMID=21765104
|Title=Evaluation of 19 autoimmune disease-associated loci with rheumatoid arthritis in a Colombian population: evidence for replication and gene-gene interaction.
|OA=1
}}

{{GET Evidence
|impact=pathogenic
|qualified_impact=Insufficiently evaluated pathogenic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs3890745
|overall_frequency_n=61
|overall_frequency_d=128
|overall_frequency=0.476562
|n_genomes=39
|n_genomes_annotated=0
|n_haplomes=49
|n_articles=0
|n_articles_annotated=0
|in_gwas=Y
|in_pharmgkb=Y
|autoscore=2
|webscore=N
}}

{{PMID Auto
|PMID=22922229
|Title=Seven newly identified loci for autoimmune thyroid disease.
|OA=1
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Affy GenomeWide 6}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}