{{Rsnum
|rsid=3900940
|Gene=MYH15
|Chromosome=3
|position=108428881
|Orientation=plus
|ReferenceAllele=A
|MissenseAllele=G
|GMAF=0.1837
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;T)
|geno3=(T;T)
|Gene_s=MYH15
}}{{ population diversity
| geno1=(C;C)
| geno2=(C;T)
| geno3=(T;T)
| CEU | 8.8 | 46.9 | 44.2
| HCB | 0.0 | 0.0 | 100.0
| JPT | 0.0 | 0.0 | 100.0
| YRI | 2.0 | 29.3 | 68.7
| ASW | 0.0 | 33.3 | 66.7
| CHB | 0.0 | 0.0 | 100.0
| CHD | 0.0 | 0.9 | 99.1
| GIH | 3.0 | 27.7 | 69.3
| LWK | 0.0 | 16.4 | 83.6
| MEX | 6.9 | 31.0 | 62.1
| MKK | 3.2 | 27.6 | 69.2
| TSI | 12.7 | 38.2 | 49.0
| HapMapRevision=28
}}[[rs3900940]] is a SNP in the [[MYH15]] gene. The risk allele in terms of [[heart disease]] is [[rs3900940]](C).

This SNP is one of the 5 used by [[Celera]]'s genetic risk score (GRS) for coronary [[heart disease]] (CHD).

*[[rs20455]], in the [[KIF6]] gene
*[[rs3900940]], in the [[MYH15]] gene
*[[rs7439293]], in the [[PALLD]] gene
*[[rs2298566]], in the [[SNX19]] gene
*[[rs1010]], in the [[VAMP8]] gene

For each of the five variants, the GRS was increased by 1 if the subject was homozygous for the risk variant, unchanged if heterozygous, and decreased by 1 if the individual did not carry the variant. Therefore, individuals carrying all 10 possible risk variants (two copies of each of the five SNPs) were assigned a GRS of 5 and those carrying no risk variants a GRS of -5. A high GRS was defined as 3 or higher. Approximately 4% of the white cohort in ARIC was classified as high risk, and the hazard ratio for CHD after adjustment for traditional risk factors was a significant 1.57 (CI: 1.21-2.04; p<0.001). The results did not reproduce for African American participants.{{PMID|18073581}}

{{PharmGKB
|RSID=rs3900940
|Name_s=
|Gene_s=MYH15
|Feature=
|Evidence=PubMed ID:18073581
|Annotation=This variant is associated with an elevated risk of coronary heart diseases.
|Drugs=
|Drug Classes=
|Diseases=Coronary Disease
|Curation Level=Curated
|PharmGKB Accession ID=PA161795945
}}

{{PMID Auto
|PMID=19752551
|Title=Polymorphisms associated with both noncardioembolic stroke and coronary heart disease: vienna stroke registry
|OA=1
}}

{{PMID Auto
|PMID=19023099
|Title=Gene variants associated with ischemic stroke: the cardiovascular health study.
|OA=1
}}

{{PMID Auto
|PMID=19139070
|Title=Genome-wide analysis to predict protein sequence variations that change phosphorylation sites or their corresponding kinases.
|OA=1
}}

{{GET Evidence
|gene=MYH15
|aa_change=Thr1125Ala
|aa_change_short=T1125A
|impact=pharmacogenetic
|qualified_impact=Insufficiently evaluated pharmacogenetic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs3900940
|overall_frequency_n=2307
|overall_frequency_d=9548
|overall_frequency=0.241621
|n_genomes=14
|n_genomes_annotated=0
|n_haplomes=15
|n_articles=1
|n_articles_annotated=1
|in_pharmgkb=Y
|pph2_score=0.007
|nblosum100=1
|autoscore=1
|webscore=N
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | FTDNA2}}
{{on chip | FTDNA}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}