{{Rsnum
|rsid=3918242
|Gene=MMP9
|Chromosome=20
|position=46007337
|Orientation=plus
|GMAF=0.1478
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;T)
|geno3=(T;T)
|Gene_s=MMP9
}}[[rs3918242]] is one of two SNPs in the [[MMP9]] gene associated with increased risk for myocardial infarction, but not coronary artery disease. The relatively weak odds ratios for carriers of one [[rs3918242]](T) allele was 1.14 (p=0.06), and for (T;T) homozygotes, 1.33 (p=0.19). However, this study of 5,000+ Caucasian patients with [[heart disease]] also indicated that a composite genotype (i.e. unphased haplotype) of the two [[MMP9]] SNPs ([[rs3918242]] and [[rs17576]], respectively) yielded a significant odds ratio of 1.25 (CI: 1.07 - 1.48, p=0.007) for the (C;T)/(A;G) combination compared to (C;C)/(G;G) combination genotypes.{{PMID|17893005|OA=1
}}

{{PMID|18006768}} This [[MMP9]] SNP, located at -1,562 in the promoter region, was associated with further progression of [[breast cancer]]; in comparison to the (C;C) genotype, the odds ratio for the [[rs3918242]](C;T) genotype was 3.6 for mixed ethnicities (CI: 1.2-11.1, p=0.001), and for Caucasians only, 9.1 (CI: 1.7-48.4, p=0.01).
{{PMID Auto
|PMID=19435423
|Title=Lack of Association Between Matrix Metalloproteinase-9 and Endothelial Nitric Oxide Synthase Gene Polymorphisms and Coronary Artery Disease in Turkish Population
}}

{{PMID Auto
|PMID=20144500
|Title=Matrix metalloproteinase-9 polymorphism and risk of pelvic organ prolapse in Taiwanese women
}}

{{PMID Auto
|PMID=20184534
|Title=Association of matrix metalloproteinase 9 genotypes and cardiovascular disease risk factors with serum matrix metalloproteinase 9 concentrations in Taiwanese individuals
}}

{{PMID Auto
|PMID=20529372
|Title=Matrix metalloproteinase-9 gene polymorphisms in nasal polyposis
|OA=1
}}
{{PMID Auto
|PMID=21244504
|Title=Association of matrix metalloproteinase gene polymorphism with temporomandibular joint degeneration
}}

{{PMID Auto
|PMID=21437990
|Title=Functional polymorphism of matrix metalloproteinase-9 (MMP-9) gene and response to lithium prophylaxis in bipolar patients
}}

{{PMID Auto
|PMID=21717058
|Title=Update analysis of studies on the MMP-9 -1562 C&gt;T polymorphism and cancer risk
}}

{{PMID Auto
|PMID=22107133
|Title=Elevated plasma matrix metalloproteinase-9 protein and its gene polymorphism in patients with community-acquired pneumonia
}}

{{PMID Auto
|PMID=16356191
|Title=Regulatory polymorphisms in extracellular matrix protease genes and susceptibility to rheumatoid arthritis: a case-control study.
|OA=1
}}

{{PMID Auto
|PMID=17346338
|Title=Matrix Metalloproteinase-9 (MMP-9) polymorphisms in patients with cutaneous malignant melanoma.
|OA=1
}}

{{PMID Auto
|PMID=18512818
|Title=Association of a nonsynonymous single-nucleotide polymorphism of matrix metalloproteinase 9 with giant cell arteritis.
}}

{{PMID Auto
|PMID=18802702
|Title=Association of (-1,607) 1G/2G polymorphism of matrix metalloproteinase-1 gene with knee osteoarthritis in the Turkish population (knee osteoarthritis and MMPs gene polymorphisms).
}}

{{PMID Auto
|PMID=18805939
|Title=Functional genetic polymorphisms and female reproductive disorders: part II--endometriosis.
|OA=1
}}

{{PMID Auto
|PMID=19664242
|Title=Functional polymorphisms in matrix metalloproteinases -1, -3, -9 and -12 in relation to cervical artery dissection.
|OA=1
}}

{{PMID Auto
|PMID=20078883
|Title=Association of MMP-2 polymorphisms with severe and very severe COPD: a case control study of MMPs-1, 9 and 12 in a European population.
|OA=1
}}

{{PMID Auto
|PMID=21161369
|Title=Current evidence on the relationship between four polymorphisms in the matrix metalloproteinases (MMP) gene and breast cancer risk: a meta-analysis.
}}

{{PMID Auto
|PMID=21455563
|Title=Analysis of matrix metalloproteinase-9 gene polymorphism -1562 C/T in patients suffering from systemic sclerosis with and without ulcers.
}}

{{PMID Auto
|PMID=21844877
|Title=Matrix metalloproteinase-9 genetic variations affect MMP-9 levels in obese children.
}}

{{PMID Auto
|PMID=22304569
|Title=Functional polymorphism located in mmp-9 gene promoter is strongly associated with obesity.
}}

{{PMID Auto
|PMID=23257253
|Title=Expression of matrix metalloproteinase-2 and matrix metalloproteinase-9 in recurrent chronic rhinosinusitis with nasal polyposis
}}

{{PMID Auto
|PMID=23734748
|Title=Association of genes of protease-antiprotease balance pathway to lung function and emphysema subtypes
|OA=1
}}

{{PMID Auto
|PMID=23813847
|Title=The association of genetic variants of matrix metalloproteinases with abdominal aortic aneurysm: a systematic review and meta-analysis
}}

{{PMID Auto
|PMID=23819814
|Title=Association of Genetic Polymorphisms in Matrix Metalloproteinase-9 and Coronary Artery Disease in Chinese Han Population: A Case-Control Study
}}

{{PMID Auto
|PMID=23819551
|Title=Genetic polymorphisms in matrix metalloproteinases (MMPs) and tissue inhibitors of MPs (TIMPs), and bladder cancer susceptibility
}}

{{PMID Auto
|PMID=24043671
|Title=A Functional Single Nucleotide Polymorphism -1562C&gt;T in the Matrix Metalloproteinase-9 Promoter Is Associated With Type 2 Diabetes and Diabetic Foot Ulcers
}}

{{PMID Auto
|PMID=24291031
|Title=Association of APOE, GCPII and MMP9 polymorphisms with common diseases and lipid levels in an older adult/elderly cohort
}}

{{PMID Auto
|PMID=24357512
|Title=Gelatinase B (-1562C/T) polymorphism in tumor progression and invasion of breast cancer
}}

{{PMID Auto
|PMID=23010359
|Title=Functional matrix metalloproteinase (MMP)-9 genetic variants modify the effects of hemodialysis on circulating MMP-9 levels.
}}

{{PMID Auto
|PMID=23274712
|Title=Genetic polymorphisms and the risk of myocardial infarction in patients under 45 years of age.
|OA=1
}}

{{on chip | 23andMe v3}}
{{on chip | HumanOmni1Quad}}