{{Rsnum
|rsid=3918396
|Gene=ADAM33
|Chromosome=20
|position=3671118
|Orientation=plus
|ReferenceAllele=G
|MissenseAllele=A
|GMAF=0.04821
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
|Gene_s=ADAM33
}}[[rs3918396]], also known as Ile710Val or S-1, is a SNP in the ADAM metallopeptidase domain 33 [[ADAM33]] gene.

A study of ~600 non-Hispanic white males who smoked concluded that [[rs3918396]](G;G) carriers, i.e. those homozygous for the most common allele, were more likely (p< 0.0026, after Bonferroni correction) to develop [[chronic obstructive pulmonary disease]] (COPD) than carriers of one or two [[rs3918396]](A) alleles.{{doi|10.1186/1465-9921-10-21}}

{{Venter SNP
|rsid=3918396
|allele=T
|frequency=
|uid=1103643143768
|type=heterozygous_SNP
|hugo=ADAM33
|ensembl gene=ENSG00000149451
|ensembl transcript=ENST00000341587
|sift=TOLERATED
|disease=Defects in ADAM33 may be a cause of susceptibility to asthma.
}}

{{ neighbor
| rsid = 44707
| distance = 539
}}
{{ neighbor
| rsid = 612709
| distance = 442
}}

{{PMID Auto
|PMID=19236319
|Title=Smoke exposure interacts with ADAM33 polymorphisms in the development of lung function and hyperresponsiveness
}}

{{PMID Auto
|PMID=12695330
|Title=Exo-proofreading, a versatile SNP scoring technology.
|OA=1
}}

{{PMID Auto
|PMID=16784537
|Title=The role of polymorphisms in ADAM33, a disintegrin and metalloprotease 33, in childhood asthma and lung function in two German populations.
|OA=1
}}

{{PMID Auto
|PMID=17878941
|Title=ADAM33, a new candidate for psoriasis susceptibility.
|OA=1
}}

{{PMID Auto
|PMID=18778489
|Title=Association of ADAM33 gene polymorphisms with adult allergic asthma and rhinitis in a Chinese Han population.
|OA=1
}}

{{PMID Auto
|PMID=19284602
|Title=Adam33 polymorphisms are associated with COPD and lung function in long-term tobacco smokers.
|OA=1
}}

{{GET Evidence
|gene=ADAM33
|aa_change=Val710Ile
|aa_change_short=V710I
|impact=not reviewed
|qualified_impact=Insufficiently evaluated not reviewed
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs3918396
|overall_frequency_n=704
|overall_frequency_d=10744
|overall_frequency=0.0655249
|n_genomes=4
|n_genomes_annotated=0
|n_haplomes=4
|n_articles=0
|n_articles_annotated=0
|pph2_score=0.013
|nblosum100=-4
|autoscore=0
|webscore=N
}}

{{PMID Auto
|PMID=23245479
|Title=The association between the IL-4, ADRβ2 and ADAM 33 gene polymorphisms and asthma in the Taiwanese population
}}

{{PMID Auto
|PMID=22871616
|Title=T1 and T2 ADAM33 single nucleotide polymorphisms and the risk of childhood asthma in a Saudi Arabian population: a pilot study.
}}

{{PMID Auto
|PMID=23380143
|Title=A disintegrin and metalloprotease 33 (ADAM33) gene polymorphisms and the risk of asthma: a meta-analysis.
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | FTDNA2}}
{{on chip | HumanOmni1Quad}}