{{Rsnum
|rsid=3924999
|Gene=NRG1
|Chromosome=8
|position=32595840
|Orientation=minus
|ReferenceAllele=G
|MissenseAllele=A
|GMAF=0.4114
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;T)
|geno3=(T;T)
|Gene_s=NRG1
}}{{ population diversity
| geno1=(C;C)
| geno2=(C;T)
| geno3=(T;T)
| CEU | 33.0 | 48.2 | 18.8
| HCB | 5.9 | 35.3 | 58.8
| JPT | 4.4 | 32.7 | 62.8
| YRI | 95.9 | 4.1 | 0.0
| ASW | 80.7 | 14.0 | 5.3
| CHB | 5.9 | 35.3 | 58.8
| CHD | 7.4 | 26.9 | 65.7
| GIH | 35.6 | 42.6 | 21.8
| LWK | 76.4 | 22.7 | 0.9
| MEX | 43.1 | 43.1 | 13.8
| MKK | 63.5 | 33.3 | 3.2
| TSI | 41.2 | 46.1 | 12.7
| HapMapRevision=28
}}a significant association between [[rs3924999]] and [[Alzheimer's disease]] with psychosis

{{Venter SNP
|rsid=3924999
|allele=A
|frequency=0.358
|uid=1103652290191
|type=homozygous_SNP
|hugo=NRG1
|ensembl gene=ENSG00000157168
|ensembl transcript=ENST00000287840
|sift=TOLERATED
|disease=A rare chromosomal aberration involving NRG1 produces gamma-heregulin. Translocation t(8;11) with ODZ4. The translocation fuses the 5'end of ODZ4 to NRG1 (isoform 8). The product of this translocation was first thought to be an alternatively spliced isoform. Gamma-heregulin is a soluble activating ligand for the ERBB2-ERBB3 receptor complex and acts as an autocrine growth factor in a specific breast cancer cell line (MDA-MB-175). Not detected in breast carcinoma samples, including ductal, lobular, medullary, and mucinous histological types, neither in other breast cancer cell lines.
}}

{{omim
|desc=ALZHEIMER DISEASE; AD
|id=104300
|rsnum=3924999
}}

{{omim
|desc=NEUREGULIN 1; NRG1
|id=142445
|rsnum=3924999
}}

{{PMID Auto
|PMID=19394386
|Title=Genetic association analysis of NRG1 with methamphetamine-induced psychosis in a Japanese population
}}

{{PMID Auto
|PMID=20497232
|Title=Association of Neuregulin 1 rs3924999 Genotype with Antisaccades and Smooth Pursuit Eye Movements
}}
{{PMID Auto
|PMID=20182055
|Title=No association between neuregulin 1 and psychotic symptoms in Alzheimer's disease patients
}}

{{PMID Auto
|PMID=21745728
|Title=Lack of association to a NRG1 missense polymorphism in schizophrenia or bipolar disorder in a Costa Rican population
|OA=1
}}

{{PMID Auto
|PMID=22467496
|Title=Association study of neuregulin 1 gene polymorphisms with auditory p300 in schizophrenia.
}}

{{PMID Auto
|PMID=12874607
|Title=Association study of neuregulin 1 gene with schizophrenia.
}}

{{PMID Auto
|PMID=16219117
|Title=Neuregulin 1 gene and variations in perceptual aberration of schizotypal personality in adolescents.
}}

{{PMID Auto
|PMID=17598910
|Title=Interactions among genes in the ErbB-Neuregulin signalling network are associated with increased susceptibility to schizophrenia.
|OA=1
}}

{{PMID Auto
|PMID=17631867
|Title=Evidence of missense mutations on the neuregulin 1 gene affecting function of prepulse inhibition.
|OA=1
}}

{{PMID Auto
|PMID=18478032
|Title=Neuregulin 1 in neural development, synaptic plasticity and schizophrenia.
|OA=1
}}

{{PMID Auto
|PMID=19199244
|Title=[Association analysis of neuregulin 1 gene polymorphism with schizophrenia in Chinese Han population].
}}

{{PMID Auto
|PMID=19521112
|Title=Analysis of a promoter polymorphism in the SMDF neuregulin 1 isoform in Schizophrenia.
|OA=1
}}

{{PMID Auto
|PMID=19545856
|Title=Sensorimotor gating depends on polymorphisms of the serotonin-2A receptor and catechol-O-methyltransferase, but not on neuregulin-1 Arg38Gln genotype: a replication study.
|OA=1
}}

{{PMID Auto
|PMID=21035784
|Title=The influence of schizophrenia-related neuregulin-1 polymorphisms on sensorimotor gating in healthy males.
}}

{{GET Evidence
|gene=NRG1
|aa_change=Arg38Gln
|aa_change_short=R38Q
|impact=not reviewed
|qualified_impact=Insufficiently evaluated not reviewed
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs3924999
|overall_frequency_n=3317
|overall_frequency_d=10758
|overall_frequency=0.308329
|n_genomes=28
|n_genomes_annotated=0
|n_haplomes=38
|n_articles=0
|n_articles_annotated=0
|pph2_score=0.989
|nblosum100=0
|autoscore=1
|webscore=N
}}

{{PMID Auto
|PMID=23360725
|Title=Association study of neuregulin-1 gene polymorphisms in a North Indian schizophrenia sample
}}

{{PMID Auto
|PMID=23489597
|Title=Neuregulin-1 (NRG-1) and its susceptibility to schizophrenia: a case-control study and meta-analysis
}}

{{PMID Auto
|PMID=25106628
|Title=Drugs Targeting SNPrs35753505 of the NRG1 Gene may Prevent the Association of Schizophrenia in a Pakistani Population
}}
{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | FTDNA2}}
{{on chip | FTDNA}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}