{{Rsnum
|rsid=3935591
|Gene=HERC2
|Chromosome=15
|position=28128866
|Orientation=minus
|GMAF=0.4917
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
|Gene_s=HERC2
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;G)
| geno3=(G;G)
| CEU | 0.9 | 23.0 | 76.1
| HCB | 50.4 | 43.8 | 5.8
| JPT | 62.8 | 28.3 | 8.8
| YRI | 74.1 | 21.8 | 4.1
| ASW | 43.9 | 43.9 | 12.3
| CHB | 50.4 | 43.8 | 5.8
| CHD | 49.5 | 43.1 | 7.3
| GIH | 35.6 | 48.5 | 15.8
| LWK | 71.8 | 24.5 | 3.6
| MEX | 13.8 | 44.8 | 41.4
| MKK | 58.1 | 38.7 | 3.2
| TSI | 18.6 | 41.2 | 40.2
| HapMapRevision=28
}}[[rs3935591]] is part of a haplotype spanning 166kB on chromosome 15, defined by 13 SNPs listed below, found in 97% of all Caucasians with blue eyes. In this haplotype, variations in [[rs1129038]] and [[rs12913832]] are relatively common in Caucasians though rare among other ethnic groups.{{PMID|18172690}} 

The "h-1" haplotype found in homozygous state in 97% of individuals with blue [[eye color]] is composed as follows {{PMID|18172690}}:

[[rs4778241]](C)

[[rs1129038]](A)

[[rs12593929]](A)

[[rs12913832]](G)

[[rs7183877]](C)

[[rs3935591]](G)

[[rs7170852]](A)

[[rs2238289]](T)

[[rs3940272]](C)

[[rs8028689]](T)

[[rs2240203]](A)

[[rs11631797]](G)

[[rs916977]](G)

{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | FTDNA2}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}