{{Rsnum
|rsid=3948464
|Gene=SP110
|Chromosome=2
|position=230185999
|Orientation=minus
|ReferenceAllele=C
|MissenseAllele=T
|GMAF=0.1028
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;T)
|geno3=(T;T)
|Gene_s=SP110
}}{{ population diversity
| geno1=(C;C)
| geno2=(C;T)
| geno3=(T;T)
| CEU | 70.8 | 29.2 | 0.0
| HCB | 99.3 | 0.7 | 0.0
| JPT | 100.0 | 0.0 | 0.0
| YRI | 75.5 | 21.8 | 2.7
| ASW | 78.9 | 19.3 | 1.8
| CHB | 99.3 | 0.7 | 0.0
| CHD | 0.0 | 0.0 | 0.0
| GIH | 91.1 | 7.9 | 1.0
| LWK | 57.3 | 40.9 | 1.8
| MEX | 89.7 | 8.6 | 1.7
| MKK | 57.1 | 34.6 | 8.3
| TSI | 81.4 | 18.6 | 0.0
| HapMapRevision=28
}}

associated with genetic susceptibility to [[tuberculosis]] in West Africa

{{omim
|id=607948
|desc=MYCOBACTERIUM TUBERCULOSIS, SUSCEPTIBILITY TO
|rsnum=3948464
}}

{{omim
|id=604457
|desc=NUCLEAR BODY PROTEIN SP110; SP110
|rsnum=3948464
}}

{{PMID Auto
|PMID=21033425
|Title=[Study on relation between Sp110 gene polymorphism and tuberculosis genetic susceptibility of Chongqing Han People]
}}

{{omim
|id=604457
|rsnum=3948464
|variant=0003
}}

{{ClinVar
|rsid=3948464
|Reversed=1
|FwdREF=T
|FwdALT=C
|REF=A
|ALT=G
|RSPOS=231050715
|CHROM=2
|GMAF=0.1026
|dbSNPBuildID=108
|SSR=0
|SAO=1
|VP=0x05016800000015051f110100
|GENEINFO=SP110:3431
|GENE_NAME=SP110
|GENE_ID=3431
|WGT=0
|VC=SNV
|CLNALLE=1
|CLNHGVS=NC_000002.11:g.231050715A>G
|CLNSRC=OMIM Allelic Variant
|CLNORIGIN=1
|CLNSRCID=604457.0003
|CLNSIG=255
|CLNCUI=C1834752
|CLNDBN=Mycobacterium tuberculosis, susceptibility to
|Disease=Mycobacterium tuberculosis
|CLNACC=RCV000005877.1
|Tags=RV;PM;PMC;SLO;VLD;G5;HD;GNO;KGPhase1;KGPilot123;KGPROD;OTHERKG;PH3;LSD;OM
|CAF=0.1028; 0.8972
|CLNDSDB=MedGen:OMIM:Orphanet
|CLNDSDBID=C1834752:607948:3389
|COMMON=1
}}

{{PMID|16803959|OA=1
}} Variants in the SP110 gene are associated with genetic susceptibility to tuberculosis in West Africa.

{{PMID|20196868|OA=1
}} Polymorphisms in IL-1beta, vitamin D receptor Fok1, and Toll-like receptor 2 are associated with extrapulmonary tuberculosis.

{{PMID|22691368}} SP110 gene polymorphisms and tuberculosis susceptibility: A systematic review and meta-analysis based on 10 624 subjects.

{{GET Evidence
|gene=SP110
|aa_change=Leu425Ser
|aa_change_short=L425S
|impact=pathogenic
|qualified_impact=Low clinical importance, Uncertain pathogenic
|inheritance=undefined
|quality_scores=Array
|dbsnp_id=rs3948464
|overall_frequency_n=9288
|overall_frequency_d=10758
|overall_frequency=0.863357
|n_genomes=56
|n_genomes_annotated=0
|n_haplomes=103
|n_articles=1
|n_articles_annotated=1
|qualityscore_in_silico=0
|qualitycomment_in_silico=Y
|qualityscore_case_control=4
|qualitycomment_case_control=Y
|qualityscore_familial=0
|qualityscore_severity=4
|qualitycomment_severity=Y
|qualityscore_treatability=4
|qualitycomment_treatability=Y
|gene_in_genetests=Y
|in_omim=Y
|genetests_testable=Y
|genetests_reviewed=Y
|nblosum100=6
|autoscore=4
|webscore=N
|variant_evidence=0
|clinical_importance=0
|summary_short=This variant is associated with a slightly increased risk of tuberculosis. It is unclear whether it is itself causal, or in linkage disequilibrium with some other causal variant that has a stronger effect.
}}

{{PMID Auto
|PMID=22522001
|Title=Polymorphisms in SP110 are not associated with pulmonary tuberculosis in Indonesians
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Affy GenomeWide 6}}
{{on chip | FTDNA2}}
{{on chip | FTDNA}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}