{{Rsnum
|rsid=397514693
|Chromosome=17
|Orientation=minus
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
|Gene=CSNK1D
|position=82265736
|Gene_s=CSNK1D
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
}}[[rs397514693]], also known as His46Arg or H46R, is a SNP in the casein kinase 1, delta [[CSNK1D]] gene.

Heterozygotes for [[rs397514693]] have been reported to have a [[sleep disorder]], Familial Advanced Sleep Phase syndrome 2 (FASPS2), and it is therefore considered to be inherited as an autosomal dominant trait. The condition is marked by a ~4 hour shift towards earlier bedtime and rising time compared to most people.{{PMID|23636092}}

There is also a report that finds a complex connection to [[migraine]] in association with this SNP, requiring further study.{{PMID|23636092}}
{{ClinVar
|ALT=C
|CHROM=17
|CLNACC=RCV000043507.3
|CLNALLE=1
|CLNDBN=Advanced sleep phase syndrome, familial, 2
|CLNDSDB=MedGen:OMIM:Orphanet
|CLNDSDBID=CN169521:615224:164736
|CLNHGVS=NC_000017.10:g.80223612T>C
|CLNSIG=5
|CLNSRC=OMIM Allelic Variant
|CLNSRCID=600864.0002
|Disease=Advanced sleep phase syndrome
|FwdALT=G
|FwdREF=A
|GENEINFO=CSNK1D:1453
|GENE_ID=1453
|GENE_NAME=CSNK1D
|REF=T
|RSPOS=80223612
|Reversed=1
|SAO=0
|SSR=0
|Tags=RV;PM;OTHERKG;LSD;OM
|VC=SNV
|VP=0x050060000000000002110100
|WGT=0
|dbSNPBuildID=136
|rsid=397514693
}}