{{Rsnum
|rsid=405509
|Gene=APOE
|Chromosome=19
|position=44905579
|Orientation=plus
|GMAF=0.4931
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;C)
|geno3=(C;C)
|Gene_s=APOE
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;C)
| geno3=(C;C)
| CEU | 27.4 | 46.9 | 25.7
| HCB | 48.9 | 43.1 | 8.0
| JPT | 52.2 | 38.9 | 8.8
| YRI | 4.1 | 35.4 | 60.5
| ASW | 3.5 | 50.9 | 45.6
| CHB | 48.9 | 43.1 | 8.0
| CHD | 44.0 | 47.7 | 8.3
| GIH | 30.7 | 45.5 | 23.8
| LWK | 10.0 | 39.1 | 50.9
| MEX | 31.0 | 37.9 | 31.0
| MKK | 9.0 | 41.7 | 49.4
| TSI | 19.6 | 54.9 | 25.5
| HapMapRevision=28
}}
{{PMID|17658295}} obstructive sleep apnea [[rs405509]]

{{PMID|19172988|OA=1
}} Significant [[Alzheimer's disease]] associations with were found for [[rs449647]](A;A) and [[rs405509]](G;G) genotypes (positive), and [[rs449647]](A;T) and [[rs405509]](T;T)

{{ neighbor
| rsid = 440446
| distance = 331
}}

{{PMID Auto
|PMID=19282863
|Title=Association of candidate gene polymorphisms with chronic kidney disease in Japanese individuals with hypertension
}}
{{PMID Auto
|PMID=19384966
|Title=Age-related macular degeneration and functional promoter and coding variants of the apolipoprotein E gene
}}

{{PMID Auto
|PMID=19808960
|Title=Apolipoprotein E/C1 Locus Variants Modify Renal Cell Carcinoma Risk
|OA=1
}}

{{PharmGKB
|RSID=rs405509
|Name_s=APOE:-219G-->T
|Gene_s=TOMM40, APOE, APOC1
|Feature=
|Evidence=PubMed ID:19056482
|Annotation=A study in 2150 Japanese individuals with metabolic syndrome, including 411 subjects with chronic kidney disease (CKD) and 1739 controls found that the -219G-->T SNP in APOE (rs405509) was most significantly associated with CKD in Japanese individuals with metabolic syndrome.
|Drugs=
|Drug Classes=
|Diseases=Kidney Diseases; metabolic syndrome
|Curation Level=Curated
|PharmGKB Accession ID=PA162411184
}}

{{PMID Auto
|PMID=21263195
|Title=An APOE Haplotype Associated with Decreased ?4 Expression Increases the Risk of Late Onset Alzheimer's Disease
}}
{{PMID Auto
|PMID=21266206
|Title=Association of apolipoprotein E promoter polymorphisms with bone structural traits is modified by dietary saturated fat intake - The Cardiovascular Risk in Young Finns Study
}}

{{PMID Auto
|PMID=22028770
|Title=APOE Genotype-Function Relationship: Evidence of -491 A/T Promoter Polymorphism Modifying Transcription Control but Not Type 2 Diabetes Risk
|OA=1
}}

{{PMID Auto
|PMID=16617143
|Title=Algorithm for automatic genotype calling of single nucleotide polymorphisms using the full course of TaqMan real-time data.
|OA=1
}}

{{PMID Auto
|PMID=17356695
|Title=Variation in GYS1 interacts with exercise and gender to predict cardiovascular mortality.
|OA=1
}}

{{PMID Auto
|PMID=17357073
|Title=Genetic analysis of 103 candidate genes for coronary artery disease and associated phenotypes in a founder population reveals a new association between endothelin-1 and high-density lipoprotein cholesterol.
|OA=1
}}

{{PMID Auto
|PMID=17672902
|Title=Subarachnoid hemorrhage: tests of association with apolipoprotein E and elastin genes.
|OA=1
}}

{{PMID Auto
|PMID=18161859
|Title=Does APOE explain the linkage of Alzheimer's disease to chromosome 19q13?
|OA=1
}}

{{PMID Auto
|PMID=18254975
|Title=Physiogenomic comparison of human fat loss in response to diets restrictive of carbohydrate or fat.
|OA=1
}}

{{PMID Auto
|PMID=18280754
|Title=Cholesterol-related genetic risk scores are associated with hypometabolism in Alzheimer's-affected brain regions.
|OA=1
}}

{{PMID Auto
|PMID=18813964
|Title=Alzheimer's disease risk variants show association with cerebrospinal fluid amyloid beta.
|OA=1
}}

{{PMID Auto
|PMID=18823527
|Title=A genome-wide association study for late-onset Alzheimer's disease using DNA pooling.
|OA=1
}}

{{PMID Auto
|PMID=19118814
|Title=Genome-wide association study implicates a chromosome 12 risk locus for late-onset Alzheimer disease.
|OA=1
}}

{{PMID Auto
|PMID=19327864
|Title=SNPit: a federated data integration system for the purpose of functional SNP annotation.
|OA=1
}}

{{PMID Auto
|PMID=19406964
|Title=Association of genetic variants with chronic kidney disease in Japanese individuals.
|OA=1
}}

{{PMID Auto
|PMID=19408013
|Title=Strategies and issues in the detection of pathway enrichment in genome-wide association studies.
|OA=1
}}

{{PMID Auto
|PMID=19541455
|Title=Apolipoprotein-E gene variants associated with cardiovascular risk factors in antipsychotic recipients.
}}

{{PMID Auto
|PMID=19668339
|Title=Hippocampal atrophy as a quantitative trait in a genome-wide association study identifying novel susceptibility genes for Alzheimer's disease.
|OA=1
}}

{{PMID Auto
|PMID=19734902
|Title=Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease.
|OA=1
}}

{{PMID Auto
|PMID=20396431
|Title=Genotyping sleep disorders patients.
|OA=1
}}

{{PMID Auto
|PMID=20467002
|Title=Impact of psychological stress on the associations between apolipoprotein E variants and metabolic traits: findings in an American sample of caregivers and controls.
|OA=1
}}

{{PMID Auto
|PMID=20723945
|Title=The APOE -219G/T and +113G/C polymorphisms affect insulin resistance among Turks.
}}

{{PMID Auto
|PMID=21283811
|Title=Associations between APOE variants and metabolic traits and the impact of psychological stress.
|OA=1
}}

{{PMID Auto
|PMID=21882290
|Title=Evidence of association of APOE with age-related macular degeneration: a pooled analysis of 15 studies.
|OA=1
}}

{{GET Evidence
|impact=pharmacogenetic
|qualified_impact=Insufficiently evaluated pharmacogenetic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs405509
|overall_frequency_n=70
|overall_frequency_d=118
|overall_frequency=0.59322
|n_genomes=38
|n_genomes_annotated=0
|n_haplomes=59
|n_articles=1
|n_articles_annotated=0
|in_pharmgkb=Y
|autoscore=1
|webscore=N
}}

{{PMID Auto
|PMID=22430674
|Title=Genome-wide haplotype association study identifies the FRMD4A gene as a risk locus for Alzheimer's disease.
|OA=1
}}

{{PMID Auto
|PMID=23021345
|Title=Gene-diet interactions on plasma lipid levels in the Inuit population.
}}

{{PMID Auto
|PMID=23193196
|Title=Estimation and partitioning of polygenic variation captured by common SNPs for Alzheimer's disease, multiple sclerosis and endometriosis.
|OA=1
}}

{{PMID Auto
|PMID=25085564
|Title=Influence of multiple
}}
{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | FTDNA2}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}