{{Rsnum
|rsid=4085613
|Gene=LCE3D
|Chromosome=1
|position=152577542
|Orientation=minus
|GMAF=0.4123
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;C)
|geno3=(C;C)
|effect1=
|effect2=
|effect3=
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;C)
| geno3=(C;C)
| CEU | 17.7 | 45.1 | 37.2
| HCB | 16.1 | 46.7 | 37.2
| JPT | 16.8 | 43.4 | 39.8
| YRI | 45.2 | 44.5 | 10.3
| ASW | 43.9 | 36.8 | 19.3
| CHB | 16.1 | 46.7 | 37.2
| CHD | 12.8 | 55.0 | 32.1
| GIH | 13.9 | 49.5 | 36.6
| LWK | 20.2 | 56.9 | 22.9
| MEX | 29.3 | 48.3 | 22.4
| MKK | 18.7 | 52.3 | 29.0
| TSI | 10.8 | 51.0 | 38.2
| HapMapRevision=28
}}[[rs4085613]] is a SNP in the late cornified envelope 3D [[LCE3D]] gene cluster.

[[rs4085613]] has been associated with [[psoriasis]] in a Chinese study involving 1,139 cases and 1,132 controls.{{PMID|19169255}}

See also: [http://blog.23andme.com/2009/01/26/snpwatch-new-psoriasis-snps-found-for-both-europeans-and-asians/ 23andMe blog] [[psoriasis]] 
Chinese
*[[rs4085613]](G) 	1.32x risk

{{omim
|desc=PSORIASIS SUSCEPTIBILITY 4; PSORS4
|id=603935
|rsnum=4085613
}}

{{PharmGKB
|RSID=rs4085613
|Name_s=
|Gene_s=LCE3D
|Feature=
|Evidence=PubMed ID:19169255; Web Resource:http://www.genome.gov/gwastudies/
|Annotation=GWAS results: Psoriasis genome-wide association study identifies susceptibility variants within LCE gene cluster at 1q21. (Initial Sample Size: 1,139 Chinese cases, 1,132 Chinese controls; Replication Sample Size: 5,721 Chinese cases, 7,340 Chinese controls); (Region: 1q21.3; Reported Gene(s): LCE3D, LCE3A; Risk Allele: rs4085613-A); (p-value= 7E-30).This variant is associated with Psoriasis.
|Drugs=
|Drug Classes=
|Diseases=Psoriasis
|Curation Level=Non-Curated
|PharmGKB Accession ID=PA164740047
}}

{{PMID Auto
|PMID=20643763
|Title=Variants in linkage disequilibrium with the late cornified envelope gene cluster deletion are associated with susceptibility to psoriatic arthritis
|OA=1
}}

{{PMID Auto
|PMID=21628307
|Title=Deletion of LCE3C_LCE3B is associated with rheumatoid arthritis and systemic lupus erythematosus in the Chinese Han population
}}

{{PMID Auto
|PMID=19693967
|Title=[Enlightenment from genome-wide association study to genetics of psoriasis].
}}

{{PMID Auto
|PMID=20606885
|Title=Genetics of psoriasis and psoriatic arthritis.
|OA=1
}}

{{PMID Auto
|PMID=21253569
|Title=Genome-wide association study SNPs in the human genome diversity project populations: does selection affect unlinked SNPs with shared trait associations?
|OA=1
}}

{{PMID Auto
|PMID=21304891
|Title=A study of CNVs as trait-associated polymorphisms and as expression quantitative trait loci.
|OA=1
}}

{{GET Evidence
|impact=pathogenic
|qualified_impact=Insufficiently evaluated pathogenic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs4085613
|overall_frequency_n=67
|overall_frequency_d=128
|overall_frequency=0.523438
|n_genomes=44
|n_genomes_annotated=0
|n_haplomes=57
|n_articles=0
|n_articles_annotated=0
|in_gwas=Y
|in_pharmgkb=Y
|autoscore=2
|webscore=N
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Illumina Human 1M}}