{{Rsnum
|rsid=4112788
|Gene=LCE3D
|Chromosome=1
|position=152578800
|Orientation=minus
|GMAF=0.332
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;T)
|geno3=(T;T)
|effect1=
|effect2=
|effect3=
}}{{ population diversity
| geno1=(C;C)
| geno2=(C;T)
| geno3=(T;T)
| CEU | 37.2 | 45.1 | 17.7
| HCB | 36.5 | 47.4 | 16.1
| JPT | 39.8 | 43.4 | 16.8
| YRI | 54.4 | 39.5 | 6.1
| ASW | 49.1 | 43.9 | 7.0
| CHB | 36.5 | 47.4 | 16.1
| CHD | 33.0 | 54.1 | 12.8
| GIH | 36.6 | 49.5 | 13.9
| LWK | 66.4 | 27.3 | 6.4
| MEX | 24.6 | 47.4 | 28.1
| MKK | 48.1 | 42.9 | 9.0
| TSI | 38.2 | 51.0 | 10.8
| HapMapRevision=28
}}[[rs4112788]] tags the LCE3C_LCE3B deletion that has been associated with risk for [[psoriasis]] in a study of 2,800+ samples of European ancestry.

[http://blog.23andme.com/2009/01/26/snpwatch-new-psoriasis-snps-found-for-both-europeans-and-asians/ 23andMe blog] [[psoriasis]] 
Europeans
*[[rs4112788]](G) 	1.41x risk

{{omim
|desc=PSORIASIS SUSCEPTIBILITY 4; PSORS4
|id=603935
|rsnum=4112788
}}

{{PharmGKB
|RSID=rs4112788
|Name_s=
|Gene_s=LCE3D
|Feature=
|Evidence=PubMed ID:19169253
|Annotation=This variant is a tagging SNP for LCE3C_LCE3B-del and is also strongly associated with psoriasis.
|Drugs=
|Drug Classes=
|Diseases=Psoriasis
|Curation Level=Curated
|PharmGKB Accession ID=PA162373051
}}

{{PMID Auto
|PMID=20213803
|Title=Deletion of the late cornified envelope genes, LCE3C and LCE3B, is associated with rheumatoid arthritis
}}

{{PMID Auto
|PMID=20331852
|Title=Mutation analysis of the LCE3B/LCE3C genes in Psoriasis
|OA=1
}}
{{PMID Auto
|PMID=20643763
|Title=Variants in linkage disequilibrium with the late cornified envelope gene cluster deletion are associated with susceptibility to psoriatic arthritis
|OA=1
}}

{{PMID Auto GWAS
|PMID=20953190
|Trait=None
|Title=A genome-wide association study identifies new psoriasis susceptibility loci and an interaction between HLA-C and ERAP1
|RiskAllele=
|Pval=3E-10
|OR=1.2900
|ORtxt=[1.19-1.40]
|OA=1
}}

{{PMID Auto
|PMID=21400479
|Title=Deletion of the LCE3C and LCE3Bgenes is a susceptibility factor for psoriatic arthritis: A study in Spanish and Italian populations and meta-analysis
}}

{{PMID Auto
|PMID=21628307
|Title=Deletion of LCE3C_LCE3B is associated with rheumatoid arthritis and systemic lupus erythematosus in the Chinese Han population
}}

{{PMID|19169254|OA=1
}} Genome-wide scan reveals association of psoriasis with IL-23 and NF-kappaB pathways.

{{PMID|19439430|OA=1
}} Deletion of LCE3C and LCE3B genes at PSORS4 does not contribute to susceptibility to psoriatic arthritis in German patients.

{{PMID|19638187|OA=1
}} Genetic susceptibility to psoriasis: an emerging picture.

{{PMID|21509048}} Deletion of the late cornified envelope genes LCE3C and LCE3B is associated with psoriasis in a Chinese population.

{{GET Evidence
|impact=pharmacogenetic
|qualified_impact=Insufficiently evaluated pharmacogenetic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs4112788
|overall_frequency_n=80
|overall_frequency_d=128
|overall_frequency=0.625
|n_genomes=45
|n_genomes_annotated=0
|n_haplomes=69
|n_articles=1
|n_articles_annotated=0
|in_pharmgkb=Y
|autoscore=1
|webscore=N
}}

{{PMID Auto
|PMID=23594316
|Title=Worldwide population distribution of the common LCE3C-LCE3B deletion associated with psoriasis and other autoimmune disorders
|OA=1
}}

{{PMID Auto
|PMID=24566688
|Title=Deletion of late cornified envelope genes, LCE3C_LCE3B-del, is not associated with psoriatic arthritis in Tunisian patients
}}
{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Illumina Human 1M}}