{{Rsnum
|rsid=4124874
|Gene=UGT1A10
|Chromosome=2
|position=233757013
|Orientation=minus
|GMAF=0.4968
|Gene_s=UGT1A3,UGT1A4,UGT1A5,UGT1A6,UGT1A7,UGT1A8,UGT1A9,UGT1A10
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;C)
|geno3=(C;C)
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;C)
| geno3=(C;C)
| CEU | 31.0 | 47.8 | 21.2
| HCB | 46.3 | 47.1 | 6.6
| JPT | 50.0 | 40.0 | 10.0
| YRI | 0.7 | 16.4 | 82.9
| ASW | 1.8 | 42.1 | 56.1
| CHB | 46.3 | 47.1 | 6.6
| CHD | 45.4 | 46.3 | 8.3
| GIH | 12.1 | 54.5 | 33.3
| LWK | 0.0 | 22.0 | 78.0
| MEX | 27.6 | 43.1 | 29.3
| MKK | 3.2 | 26.9 | 69.9
| TSI | 30.0 | 50.0 | 20.0
| HapMapRevision=28
}}{{PharmGKB
|RSID=rs4124874
|Name_s=UGT1A1*60;UGT1A1:-3279T>G;UGT1A1:-3263T>G
|Gene_s=UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT1A1
|Feature=Intron, Intron, Intron, Intron, Intron, Intron, Intron, Intron, NA
|Evidence=Web Resource:http://www.pharmgkb.org/search/annotatedGene/ugt1a1/variant.jsp
|Annotation=*60 is a common variant of UGT1A1. It is located in the Phenobarbital Response Enhancer Module (an upstream regulatory sequence) and may be involved in irinotecan response and in Gilbert syndrome.
|Drugs=irinotecan
|Drug Classes=
|Diseases=Gilbert's syndrome
|Curation Level=In-Depth
|PharmGKB Accession ID=PA162263493
}}

The (C;C) genotype is linked to reduced UGT1A1 activity, and increased Bilirubin, except in people of African origin for whom the T allele is a risk factor for breast cancer.

{{PharmGKB
|RSID=rs4124874
|Name_s=UGT1A1*60; UGT1A1:-3279T>G
|Gene_s=UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT1A1
|Feature=Intron, Intron, Intron, Intron, Intron, Intron, Intron, Intron, NA
|Evidence=PubMed ID:11906189
|Annotation=Associated with hyperbilirubinemia in Japanese.
|Drugs=
|Drug Classes=
|Diseases=
|Curation Level=Curated
|PharmGKB Accession ID=PA161145126
}}

{{PMID|17424838}} [Genetic polymorphisms of MPO, NQO1, GSTP1, UGT1A6 associated with susceptibility of chronic benzene poisoning].

{{PMID|17498780}} The influence of metabolic gene polymorphisms on urinary 1-hydroxypyrene concentrations in Chinese coke oven workers.

{{PMID|18992148|OA=1
}} Low-penetrance alleles predisposing to sporadic colorectal cancers: a French case-controlled genetic association study.

{{PMID|19267064}} [Relationship between genetic polymorphisms of phase I and phase II metabolizing enzymes and DNA damage of workers exposed to vinyl chloride monomer].

{{PMID|19482841|OA=1
}} Serum bilirubin levels on ICU admission are associated with ARDS development and mortality in sepsis.

{{PMID|20389299|OA=1
}} Pazopanib-induced hyperbilirubinemia is associated with Gilbert's syndrome UGT1A1 polymorphism.

{{GET Evidence
|impact=pharmacogenetic
|qualified_impact=Insufficiently evaluated pharmacogenetic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs4124874
|overall_frequency_n=73
|overall_frequency_d=128
|overall_frequency=0.570312
|n_genomes=46
|n_genomes_annotated=0
|n_haplomes=65
|n_articles=1
|n_articles_annotated=0
|in_pharmgkb=Y
|autoscore=1
|webscore=N
}}

{{PMID Auto
|PMID=24865931
|Title=Combined effects of the UGT1A1 and OATP2 gene polymorphisms as major risk factor for unconjugated hyperbilirubinemia in Indian neonates
}}
{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | FTDNA2}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}