{{Rsnum
|rsid=4129267
|Gene=IL6R
|Chromosome=1
|position=154453788
|Orientation=plus
|GMAF=0.3186
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;T)
|geno3=(T;T)
|Gene_s=IL6R
}}{{ population diversity
| geno1=(C;C)
| geno2=(C;T)
| geno3=(T;T)
| CEU | 43.4 | 43.4 | 13.3
| HCB | 36.5 | 48.2 | 15.3
| JPT | 42.5 | 43.4 | 14.2
| YRI | 87.1 | 12.2 | 0.7
| ASW | 70.2 | 29.8 | 0.0
| CHB | 36.5 | 48.2 | 15.3
| CHD | 33.9 | 44.0 | 22.0
| GIH | 48.5 | 48.5 | 3.0
| LWK | 86.4 | 13.6 | 0.0
| MEX | 27.6 | 41.4 | 31.0
| MKK | 79.5 | 17.9 | 2.6
| TSI | 36.3 | 50.0 | 13.7
| HapMapRevision=28
}}

{{PMID|18464913|OA=1
}} soluble [[IL6R]] (sIL-6R) protein levels

{{GWAS Summary
|SNP=rs4129267
|PubMedID=18464913
|Condition=Protein quantitative trait loci
|Gene=IL6R
|Risk Allele=C
|pValue=2.00E-057
|OR=NA
|95CI=
|OA=1
}}

{{ neighbor
| rsid = 8192284
| distance = 707
}}

{{PMID Auto GWAS
|PMID=17903307
|Trait=Other pulmonary function traits
|Title=Framingham Heart Study genome-wide association: results for pulmonary function measures
|RiskAllele=
|Pval=0.0000069999999999999999
|OR=NR
|ORtxt=NR
|OA=1
}}

{{PharmGKB
|RSID=rs4129267
|Name_s=
|Gene_s=IL6R
|Feature=
|Evidence=PubMed ID:18464913; Web Resource:http://www.genome.gov/gwastudies/
|Annotation=GWAS Results: A Genome-Wide Association Study Identifies Protein Quantitative Trait Loci (pQTLs) (Initial Sample Size: 1,200 individuals; Replication Sample Size: NR; Risk/trait Allele: rs4129267-C).
|Drugs=
|Drug Classes=
|Diseases=
|Curation Level=Non-Curated
|PharmGKB Accession ID=PA162356798
}}

{{PMID Auto GWAS
|PMID=21300955
|Trait=None
|Title=Meta-Analysis of Genome-Wide Association Studies in >80 000 Subjects Identifies Multiple Loci for C-Reactive Protein Levels
|RiskAllele=C
|Pval=2E-48
|OR=0.0790
|ORtxt=[0.07-0.09] unit increase
|OA=1
}}

{{PMID Auto
|PMID=21907864
|Title=Identification of IL6R and chromosome 11q13.5 as risk loci for asthma
|OA=1
}}

{{PMID Auto
|PMID=22554704
|Title=The IL6R variation Asp(358)Ala is a potential modifier of lung function in subjects with asthma
|OA=1
}}

{{PMID|17903300|OA=1
}} Genome-wide association to body mass index and waist circumference: the Framingham Heart Study 100K project.

{{PMID|18439548|OA=1
}} Loci related to metabolic-syndrome pathways including LEPR,HNF1A, IL6R, and GCKR associate with plasma C-reactive protein: the Women's Genome Health Study.

{{PMID|18439552|OA=1
}} Polymorphisms of the HNF1A gene encoding hepatocyte nuclear factor-1 alpha are associated with C-reactive protein.

{{PMID|18852330|OA=1
}} Interleukin-6 receptor gene, plasma C-reactive protein, and diabetes risk in women.

{{PMID|19060910|OA=1
}} Genome-wide association analysis of metabolic traits in a birth cohort from a founder population.

{{PMID|19197348|OA=1
}} Genome-wide association studies in an isolated founder population from the Pacific Island of Kosrae.

{{PMID|19468064|OA=1
}} Parasites represent a major selective force for interleukin genes and shape the genetic predisposition to autoimmune conditions.

{{PMID|20031577|OA=1
}} Novel loci, including those related to Crohn disease, psoriasis, and inflammation, identified in a genome-wide association study of fibrinogen in 17 686 women: the Women's Genome Health Study.

{{PMID|21496483}} Fatigued breast cancer survivors and gene polymorphisms in the inflammatory pathway.

{{PMID|21647738|OA=1
}} Genome-wide association with C-reactive protein levels in CLHNS: evidence for the CRP and HNF1A loci and their interaction with exposure to a pathogenic environment.

{{GET Evidence
|impact=pathogenic
|qualified_impact=Insufficiently evaluated pathogenic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs4129267
|overall_frequency_n=39
|overall_frequency_d=128
|overall_frequency=0.304688
|n_genomes=23
|n_genomes_annotated=0
|n_haplomes=30
|n_articles=0
|n_articles_annotated=0
|in_gwas=Y
|in_pharmgkb=Y
|autoscore=2
|webscore=N
}}

{{PMID Auto
|PMID=23945879
|Title=A new regulatory variant in the interleukin-6 receptor gene associates with asthma risk
}}

{{PMID Auto
|PMID=25073350
|Title=[Genetic aspects of occupational chronic obstructive lung disease under exposure to various risk factors]
}}
{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Affy GenomeWide 6}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}