{{Rsnum
|rsid = 41293463
|Gene = BRCA1
|geno1 = (G;G)
|geno2 = (G;T)
|geno3 = (T;T)
|Orientation=minus
|ReferenceAllele=T
|MissenseAllele=G
|Chromosome=17
|position=43051071
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|Gene_s=BRCA1
}}[[rs41293463]] is a SNP causing an amino acid change in the breast cancer 1 [[BRCA1]] gene at amino position 1775. The more common [[rs41293463]](T) allele encodes Met, while the rare [[rs41293463]](G) allele encodes Arg.

A study found that the [[rs41293463]](G) allele has impaired transcriptional ability, and this allele was found in some patients with [[breast cancer]]. It seems likely that primarily (G;G) homozygotes would be at increased risk for [[breast cancer]] but this has not been demonstrated. {{PMID|8942979|OA=1
}}

* See also [http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=113705&a=113705_AllelicVariant0035 Omim 113705.0035]

{{omim
|id=113705
|rsnum=41293463
|variant=0035
}}

{{ClinVar
|rsid=41293463
|Reversed=1
|FwdREF=T
|FwdALT=A,G
|REF=A
|ALT=C,T
|RSPOS=41203088
|CHROM=17
|dbSNPBuildID=127
|SSR=0
|SAO=1
|VP=0x050360000000000102110100
|GENEINFO=BRCA1:672
|GENE_NAME=BRCA1
|GENE_ID=672
|WGT=0
|VC=SNV
|CLNALLE=1; 2
|CLNHGVS=NC_000017.10:g.41203088A>C; NC_000017.10:g.41203088A>T
|CLNORIGIN=1
|CLNSRCID=
113705.0035; 113705.0036
|CLNSIG=255
|CLNCUI=
|CLNACC=
RCV000019264.4; RCV000048931.2; RCV000019265.3; RCV000048930.2
|Tags=RV;PM;S3D;SLO;GNO;OTHERKG;LSD;OM
|CLNDBN=Breast-ovarian cancer, familial 1; Familial cancer of breast
|CLNDSDB=GeneReviews:MedGen:OMIM:Orphanet; GeneReviews:MedGen:OMIM:SNOMED_CT
|CLNDSDBID=NBK1247:C2676676:604370:145; NBK1247:C0346153:114480:254843006
|CLNSRC=OMIM Allelic Variant
|Disease=Breast-ovarian cancer; Familial cancer of breast
}}

{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}