{{Rsnum
|rsid=4140564
|Chromosome=1
|position=186755871
|Orientation=minus
|GMAF=0.04408
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;T)
|geno3=(T;T)
|effect1=
|effect2=
|effect3=
}}{{ population diversity
| geno1=(C;C)
| geno2=(C;T)
| geno3=(T;T)
| CEU | 1.6 | 12.5 | 85.9
| HCB | 0.0 | 0.0 | 100.0
| JPT | 0.0 | 0.0 | 100.0
| YRI | 3.2 | 9.7 | 87.1
| ASW | 0.0 | 0.0 | 0.0
| CHB | 0.0 | 0.0 | 100.0
| CHD | 0.0 | 0.0 | 0.0
| GIH | 0.0 | 0.0 | 0.0
| LWK | 0.0 | 0.0 | 0.0
| MEX | 0.0 | 0.0 | 0.0
| MKK | 0.0 | 0.0 | 0.0
| TSI | 0.0 | 0.0 | 0.0
| HapMapRevision=28
}}[[rs4140564]], a SNP on chromosome 1 near the [[PTGS2]] and [[PLA2G4A]] genes, has been associated with knee [[osteoarthritis]].

A study of 255 British patients, replicated subsequently in ~2,000 UK, Dutch and US patients, found that [[rs4140564]] was associated with knee [[osteoarthritis]] in all populations studied with an overall odds ratio = 1.55, CI: 1.30-1.85, p < 6.9 x 10e-7.{{PMID|18471798|OA=1
}}

{{GWAS Summary
|SNP=rs4140564
|PubMedID=18471798
|Condition=Knee osteoarthritis
|Gene=PTGS2, PLA2G4A
|Risk Allele=
|pValue=3.00E-006
|OR=1.59
|95CI=1.31-1.94
|OA=1
}}

{{PharmGKB
|RSID=rs4140564
|Name_s=
|Gene_s=-
|Feature=
|Evidence=PubMed ID:18471798; Web Resource:http://www.genome.gov/gwastudies/
|Annotation=GWAS results: Genome-wide Association Scan Identifies a Prostaglandin-Endoperoxide Synthase 2 Variant Involved in Risk of Knee Osteoarthritis (Initial Sample Size: 357 cases, 285 controls; Replication Sample Size: 1,177 cases, 2,372 controls). This variant is associated with Knee osteoarthritis.
|Drugs=
|Drug Classes=
|Diseases=Osteoarthritis, Knee
|Curation Level=Non-Curated
|PharmGKB Accession ID=PA162356477
}}

{{PharmGKB
|RSID=rs4140564
|Name_s=
|Gene_s=-
|Feature=
|Evidence=PubMed ID:18471798
|Annotation=rs4140564, a tagging SNP for the LD block that contains PTGS2, was found to be associated with risk for Knee Osteoarthritis in five white case-control cohorts from the US, the UK and the Netherlands.
|Drugs=
|Drug Classes=
|Diseases=Osteoarthritis, Knee
|Curation Level=Curated
|PharmGKB Accession ID=PA161907431
}}

{{GET Evidence
|impact=pathogenic
|qualified_impact=Insufficiently evaluated pathogenic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs4140564
|overall_frequency_n=121
|overall_frequency_d=128
|overall_frequency=0.945312
|n_genomes=55
|n_genomes_annotated=0
|n_haplomes=105
|n_articles=1
|n_articles_annotated=0
|in_gwas=Y
|in_pharmgkb=Y
|autoscore=2
|webscore=N
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}